FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(3L)BK10
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General Information
Symbol
Df(3L)BK10
Species
D. melanogaster
Name
FlyBase ID
FBab0002293
Feature type
chromosomal_deletion
Also Known As
BK10
Computed Breakpoints include

71C3;71E5

Features within 71C3--71E5
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Dp(3;3)S2
(Leicht and Bonner, 1988)
Mutagen
X ray
(Leicht and Bonner, 1988)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Zhimulev et al., 1998, Andrew et al., 1997, Rose et al., 1997, Zhimulev et al., 1997.9.29, Duffy et al., 1996, Tear et al., 1996, Pauli et al., 1995, Leicht and Bonner, 1988)
Breakpoints

71C1-71C2;71F4-71F5

(Tear et al., 1996, Leicht and Bonner, 1988)

71C;71F

(Duffy et al., 1996, Pauli et al., 1995)

71C1-72C2;71F4-71F5

(Andrew et al., 1997)

71C1-71C2;71F4

(Rose et al., 1997)

71C3;71E5

(Zhimulev et al., 1998, Zhimulev et al., 1997.9.29)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << mrn << bk2 << brm

Genetic mapping information
Comments
Comments on Cytology

All limits from polytene analysis (FBrf0098597)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
comm
(Tear et al., 1996)
CrebA
(Andrew et al., 1997, Rose et al., 1997)
dop
(Galewsky and Schulz, 1992)
fsl
(Bucciarelli et al., 2003)
mrn
(Bloomington Drosophila Stock Center, 1999.6.23)
Z600
(Großhans et al., 2003, Großhans and Wieschaus, 2000)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3L)BK10/Df(3L)ri-79c embryos show a failure to form a ventral furrow. The mesoderm primordium is internalised late.

    (Seher and Leptin, 2000)

    Df(3L)A5 complements Df(3L)Brd6 and Df(3L)Brd18 but not Df(3L)Brd20 or Df(3L)BK10. Df(3L)Q26 and Df(3L)A27 fail to complement Df(3L)Brd6, Df(3L)Brd18, Df(3L)Brd20 and Df(3L)BK10.

    (Melendez et al., 1995)
    NOT in combination with other aberrations

    88% of mutant embryos have an open ventral furrow phenotype.

    (Gawlinski et al., 2007)

    The Df(3L)BK10 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    The Df(3L)BK10 mutation induces premature mitosis in cells that form the ventral furrow. Among Df(3L)BK10 embryos, there is a small fraction containing patches of higher nuclear density which appear to be due to an extra (14th) cleavage division prior to cellularization. The nuclei/cells that divide only 13 times are more advanced than the nuclei that go through an additional mitosis and enter gastrulation later.

    (Großhans et al., 2003)

    Heterozygosity for Df(3L)BK10 results in 0.4% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Homozygous mutants embryos show a failure to form a ventral furrow. The mesoderm primordium is internalised late.

    (Seher and Leptin, 2000)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    The larval cuticle of homozygotes is weak, as seen by frequent holes at random positions in the exoskeleton.

    (Andrew et al., 1997)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    "71C3;71E5" was stated as revision.

    (Zhimulev et al., 1998, Zhimulev et al., 1997.9.29)
    Synonyms and Secondary IDs (6)
    References (41)