FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(3R)Tl-I
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General Information
Symbol
Df(3R)Tl-I
Species
D. melanogaster
Name
Deficiency (3R) Toll
FlyBase ID
FBab0002664
Feature type
chromosomal_deletion
Computed Breakpoints include

97B;97E2-97E11

Features within 97B--97E11
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Tl2
(Anderson et al., 1985)
Mutagen
X ray
(Anderson et al., 1985)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Karsch-Mizrachi and Haynes, 1993, Anderson et al., 1985)
Breakpoints

97B;97E

(Karsch-Mizrachi and Haynes, 1993, Anderson et al., 1985)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << Tl << spz << bk2 << l(3)mbt

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Karsch-Mizrachi and Haynes, 1993)
Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0042050) Left limit of break 2 from inclusion of spz (FBrf0068603) Right limit of break 2 from polytene analysis (FBrf0042050)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
ball
(Ivanovska et al., 2005)
E(rst)A5
(Tanenbaum et al., 2000)
E(rst)B6
(Tanenbaum et al., 2000)
E(rst)B37
(Tanenbaum et al., 2000)
E(rst)B47
(Tanenbaum et al., 2000)
E(rst)B80
(Tanenbaum et al., 2000)
E(rst)B203
(Tanenbaum et al., 2000)
E(rst)B246
(Tanenbaum et al., 2000)
E(rst)C6
(Tanenbaum et al., 2000)
E(rst)C14
(Tanenbaum et al., 2000)
E(rst)C41
(Tanenbaum et al., 2000)
E(rst)C45
(Tanenbaum et al., 2000)
E(rst)C109
(Tanenbaum et al., 2000)
E(rst)C137
(Tanenbaum et al., 2000)
E(rst)C317
(Tanenbaum et al., 2000)
E(rst)C329
(Tanenbaum et al., 2000)
E(rst)C383
(Tanenbaum et al., 2000)
E(rst)C389
(Tanenbaum et al., 2000)
E(rst)C532
(Tanenbaum et al., 2000)
E(rst)D19
(Tanenbaum et al., 2000)
E(rst)D151
(Tanenbaum et al., 2000)
E(rst)D184
(Tanenbaum et al., 2000)
E(rst)D187
(Tanenbaum et al., 2000)
E(rst)H54
(Tanenbaum et al., 2000)
E(rst)H74
(Tanenbaum et al., 2000)
E(rst)H125
(Tanenbaum et al., 2000)
E(rst)I2
(Tanenbaum et al., 2000)
E(rst)I12
(Tanenbaum et al., 2000)
E(rst)I19
(Tanenbaum et al., 2000)
eater
(Kocks et al., 2005)
gro
(Cook and Carpenter, 2002)
His2Av
(Cook and Carpenter, 2002)
Rb97D
(Cook and Carpenter, 2002, Castrillon et al., 1993, Karsch-Mizrachi and Haynes, 1993)
ro
(Cook and Carpenter, 2002)
scrib
(Brumby et al., 2004, Cook and Carpenter, 2002)
spz
(Morisato and Anderson, 1994)
Tl
(Cook and Carpenter, 2002, Cook, 2000.10.9, Anderson et al., 1985)
tx
(Cook and Carpenter, 2002)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
l(3)mbt
(Gateff et al., 1993)
l(3)rK344
(Cook, 2000.10.9)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3R)Tl-I/Df(3R)D605 flies are viable and fertile.

    (Kocks et al., 2005)

    Df(3R)Tl-I/Df(3R)D605 flies show a normal humoral response.

    (Kocks et al., 2005)

    Df(3R)Tl-I/Df(3R)D605 flies show strongly impaired levels of phagocytosis of gram-positive bacteria compared to wild-type or heterozygous controls. These flies also show an impairment in phagocytosis of gram-negative bacteria, althoughh to a lesser extent.

    (Kocks et al., 2005)

    Df(3R)Tl-I/Df(3R)D605 hemocytes show impaired levels of phagocytosis of both gram-positive and gram-negative bacteria, but show wild-type levels of phagocytosis of india ink carbon particles. These hemocytes appear to adhere less tightly to the larval cuticle than wild-type hemocytes.

    (Kocks et al., 2005)

    After feeding on gram-negative bacteria, Df(3R)Tl-I/Df(3R)D605 flies die more rapidly than wild-type flies. The hemolymph of these flies contains about a 10,000-fold increase in bacterial number compared to wild-type flies.

    (Kocks et al., 2005)

    Inferred to overlap with: Df(3R)Espl3.

    (Cook and Carpenter, 2002)
    NOT in combination with other aberrations

    Df(3R)D605/Df(3R)Tl-I flies ("eater null" flies) exhibit increased susceptibility to R.oryzae as compared to control wild-type flies.

    (Chamilos et al., 2008)

    Injection of spz1.9 or spz2.1 transcripts rescues spz4/Df(3R)Tl-I embryos to hatching, injection of spz2.2 weakly rescues and spz1.8 fails to rescue.

    (Morisato and Anderson, 1994)

    heterozygous females viable heterozygous females fertile

    Stocks (2)
    Notes on Origin
    Discoverer
     

    Revertant.

    (Anderson et al., 1985)

    Revertant

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (8)
    Reported As
    Symbol Synonym
    Df(3)Tl-I
    (Swaminathan et al., 2005)
    Df(3R)Tl-1
    (Hashimoto et al., 2009)
    Df(3R)Tl-I
    (Xu et al., 2023, Akbar et al., 2011, Chamilos et al., 2008, Brennan et al., 2007, Kocks et al., 2005)
    Df(3R)Tl5BRXI
    (Gateff et al., 1993)
    Df(3R)Tl5BRXI
    (Morisato and Anderson, 1994)
    Tl5BRXI
    (Anderson et al., 1985)
    eater def.
    (Guillou et al., 2016)
    Name Synonyms
    Deficiency (3R) Toll
    Secondary FlyBase IDs
      References (21)