FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(3R)by62
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General Information
Symbol
Df(3R)by62
Species
D. melanogaster
Name
Deficiency (3R) blistery
FlyBase ID
FBab0002716
Feature type
chromosomal_deletion
Also Known As
Df(3R)by62
Computed Breakpoints include
Features within 85D10--85F11
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Tp(3;2)by62
Mutagen
segregation
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Belote, 2000.1.25)
Breakpoints

85D10-85D11;85F8-85F11

(Belote, 2000.1.25)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

There is no evidence of a 2:3 translocation. The rearrangment at 85D-F looks like a typical, conventional deficiency.

(Belote, 2000.1.25)

The description of Df(3R)by62 as a deficient translocation in FBrf0051508 was an error propagated from a typographical error in FBrf0069831. The original cytological description has been retrieved from the laboratory notebook of Ken Kemphues where the deficiency is clearly described as a transposition segregant.

(Bloomington Drosophila Stock Center, 2000.2.24)
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
by
(Kemphues et al., 1983, Kemphues et al., 1980)
dc
(Craig and Brink, 1996)
dmt
(Szeged Stock Center, 1998-, Deak et al., 1997)
eca
(Bartoszewski et al., 2004)
Fmr1
(Michel et al., 2004, Dockendorff et al., 2002, Zhang et al., 2001, Wan et al., 2000)
Glut4EF
(Yazdani et al., 2008)
hty
(Szeged Stock Center, 1998-)
hyd
(Mansfield et al., 1994)
Invadolysin
(McHugh, 1999.10.4)
Kap-α3
(Szeged Stock Center, 1998-, Deak et al., 1997)
knk
(Beitel and Krasnow, 2000, Harbecke and Lengyel, 1995)
l(3)85Ee
(Lindsley and Zimm, 1992)
l(3)S007934
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S012225a
(Deak et al., 1997)
l(3)S019203
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S022122b
(Deak et al., 1997)
l(3)S023014b
(Deak et al., 1997)
l(3)S026115b
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S026409a
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S026430
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S037906
(Deak et al., 1997)
l(3)S049217d
(Deak et al., 1997)
l(3)S056113
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S065312b
(Deak et al., 1997)
l(3)S066208
(Deak et al., 1997)
l(3)S070806c
(Deak et al., 1997)
l(3)S082414a
(Deak et al., 1997)
l(3)S088712b
(Deak et al., 1997)
l(3)S105307
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S142814b
(Deak et al., 1997)
Mow
(Bhadra and Birchler, 1996)
ms(3)85E
(Matthews, 1998.8.27)
Ras85D
(Begemann et al., 1995, Rogge et al., 1992)
Scm
(Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)
sd-10
(Babcock et al., 2003)
tetra
(Uemura et al., 1993)
tws
(Merigliano et al., 2017, Spradling et al., 1999, Szeged Stock Center, 1998-, Deak et al., 1997, BDGP Project Members, 1994-1999, Uemura et al., 1993)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    In Fmr1Δ83M/Df(3R)by62 pharate adults, the α and β lobes appear very immature, resembling those seen in wild-type brains at earlier stages of metamorphosis. In many cases, the lobes appear younger than those of pupae whose β lobe fibers are just approaching the midline. The mushroom body α/β immaturity phenotype is characterised by abnormally thin α and β lobes that are very irregular along their lengths, whereas the γ lobes appear normal. Approximately 80-90% of Fmr1Δ83M/Df(3R)by62 brains show α/β immaturity. Over 90% of the mushroom bodies of Df(3R)by62 heterozygotes are immature, confirming the dominant effect of the deficiency. The severity of the Df(3R)by62 α and β lobe immaturity phenotype is ehanced by Fmr1Δ83M.

    (Michel et al., 2004)

    Fails to complement: Df(3R)swp2MICAL. Fails to complement: Df(3R)swp4. Fails to complement: Df(3R)swp7. Fails to complement: Df(3R)swp11. Fails to complement: Df(3R)swp38.

    (Terman et al., 2002)
    NOT in combination with other aberrations

    The Df(3R)by62 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable

    (Mason et al., 2004)

    Shows dominant enhancement of dominant haltere phenotype caused by Ubx195 and Ubx9.22.

    (Burnette et al., 1999)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Does not show a dose-sensitive interaction with pbhs.PB.

    (Boube et al., 1997)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Suppressor of the dosage dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

    (Begemann et al., 1995)

    Deficient embryos show an uninterpretable mutant midgut phenotype.

    (Bilder and Scott, 1995)

    Homozygous embryos show defects in cell divisions.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Embryonic lethal.

    (Mansfield et al., 1994)
    Stocks (1)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (6)
    References (73)