FB2024_03 , released June 25, 2024
Aberration: Dmel\In(3R)ScrMsc
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General Information
Symbol
In(3R)ScrMsc
Species
D. melanogaster
Name
Inversion (3R) Sex comb reduced
FlyBase ID
FBab0005682
Feature type
chromosomal_inversion
Also Known As
In(3R)Msc, In(3R)Msc1
Computed Breakpoints include

84B1;85D2

Sequence coordinates
3R:9,208,172..9,215,348 [-] (In(3R)Scr[Msc]:bk2)
(Barker et al., 1992)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
(Pattatucci et al., 1991, Scott et al., 1983)
Class of aberration (relative to wild type)
chromosomal_inversion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_inversion
(Barker et al., 1992, Pattatucci et al., 1991, Kaufman et al., 1980, Duncan and Kaufman, 1975)
Breakpoints

84B;84F

(Duncan and Kaufman, 1975)

84B1-84B2;85C6-85D2

(Kaufman et al., 1980)

84B1-84B2;84F1-84F2

(Pattatucci et al., 1991)

84B;85C-85D

(Barker et al., 1992)
Causes alleles
ScrMsc
(Southworth and Kennison, 2002, Gorman and Kaufman, 1995, Tamkun et al., 1992, Pattatucci and Kaufman, 1991, Pattatucci et al., 1991, LeMotte et al., 1989, Kennison and Russell, 1987, Riley et al., 1987, Scott et al., 1983, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980, Duncan and Kaufman, 1975)
pumMsc
(Kadyrova et al., 2007, Tadros et al., 2007, Gilboa and Lehmann, 2004, Barker et al., 1992)
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 hits ftz << bk2 hits pum

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Barker et al., 1993, Kim-Ha et al., 1991, Kuroiwa et al., 1984, Scott et al., 1983)

Breakpoint 2 was linked to an EcoRI-EcoRI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Barker et al., 1992)

Left breakpoint 62-64 kilobases distal to the proximal breakpoint of Tp(3;3)Dfdrv3 (Scott, Weiner, Hazelrigg, Polisky, Pirrotta, Scalenghe and Kaufman, 1983, Cell 35: 763-76).

Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0034841) Right limit of break 1 from complementation mapping against Scr (FBrf0039012) Left limit of break 2 from complementation mapping against pum (FBrf0055853) Right limit of break 2 from polytene analysis (FBrf0034841)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Antp
(Kuroiwa et al., 1985)
ftz
(Kuroiwa et al., 1985)
pum
(Forbes and Lehmann, 1998, Barker et al., 1992, MacDonald, 1992)
Scr
(Pattatucci and Kaufman, 1991, Pattatucci et al., 1991, Sato et al., 1983)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In this case, the "Export to Hitlist" button at left will also be disabled.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Dominant Scr phenotype (Sato et al., 1983). Recessive lethal (Duncan and Kaufman, 1975, Genetics 80: 733-52).

    Stocks (2)
    Notes on Origin
    Discoverer

    Tokunaga.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    "84B;85C--D" was stated as revision. Cytogenetic, genetic and molecular analysis of Barker et al., (Genes Dev 6:2312--2326 ) and Kemphues et al., (Genetics 105:345--356 ) supports 85C location of the right break of this inversion as opposed to 84F.

    (Barker et al., 1992)
    Synonyms and Secondary IDs (7)
    Reported As
    Symbol Synonym
    In(3R)MSC
    (Wreden et al., 1997)
    In(3R)Msc
    (Kadyrova et al., 2007, Tadros et al., 2007, Cinnamon et al., 2004, Gilboa and Lehmann, 2004, Forbes and Lehmann, 1998, Murata and Wharton, 1995, Barker et al., 1992, MacDonald, 1992, Riley et al., 1987, Kaufman et al., 1980)
    In(3R)Msc1
    (LeMotte et al., 1989, Kuroiwa et al., 1985)
    In(3R)Scr-Msc
    In(3R)Scr-Msc1
    In(3R)ScrMsc
    Name Synonyms
    Inversion (3R) Sex comb reduced
    Secondary FlyBase IDs
      References (32)