FB2024_03 , released June 25, 2024
Aberration: Dmel\Dp(1;f)γ158
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General Information
Symbol
Dp(1;f)γ158
Species
D. melanogaster
Name
FlyBase ID
FBab0024517
Feature type
free_duplication
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Dp1187-8-23
(Donaldson and Karpen, 1997, Le et al., 1995)
Mutagen
gamma ray
(Donaldson and Karpen, 1997, Le et al., 1995)
Class of aberration (relative to wild type)
free_duplication
Class of aberration (relative to progenitor)
Breakpoints

[];[]

(Le et al., 1995)
Causes alleles
yγ158
(Donaldson and Karpen, 1997, Le et al., 1995)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Used in experiments that showed that efficient achiasmate homolog disjunction in female meiosis I requires 1000kb of overlap in the centric heterochromatin and is not affected by homologous euchromatin or overall size differences. Disjunction efficiency decreases linearly as heterochromatic overlap is reduced from 1000 to 430kb. Rescue experiments with nod transgenes showed that heterochromatin does not act solely to promote chromosome movement or spindle attachment. Centric heterochromatin seems to contain multiple pairing elements that act additively to initiate or maintain the proper alignment of achiasmate chromosomes in meiosis I.

(Karpen et al., 1996)

Unchanged from progenitor. No visible structural alterations on the Dp(1;f)1187 derivative Dp1187-8-23.

(Le et al., 1995)
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
y
(Le et al., 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In this case, the "Export to Hitlist" button at left will also be disabled.
    Phenotypic Data
    In combination with other aberrations

    Terminal deficiency associated position effect variegation (TDA-PEV) of the y+ gene in Dp(1;f)γ878 is suppressed by Dp(1;f)γ158 ("trans-suppression").

    (Donaldson et al., 2002)

    Dp(1;f)γ878/Dp(1;f)γ158 heterozygotes exhibit a dramatic increase in y+ expression, relative to Dp(1;f)γ878 - nearly complete suppression of terminal deficiency induced PEV. Increased y+ expression is visible in the abdominal cuticle, wings and thoracic and triple row bristles.

    (Donaldson and Karpen, 1997)
    NOT in combination with other aberrations
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    y- ry+ derivative with no structural changes.

    (Donaldson and Karpen, 1997)
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Dp(1;f)γ158
    γ158
    (Le et al., 1995)
    Name Synonyms
    Secondary FlyBase IDs
      References (4)