FlyBase Allele Report: Dmel\abd-A[iab4,5-DB]

General Information

Symbol

Dmel\abd-A^iab4,5-DB

Species

D. melanogaster

Name

FlyBase ID

FBal0000105

Feature type

allele

Associated gene

Dmel\abd-A

Associated Insertion(s)

Carried in Construct

Also Known As

iab4,5^DB, iab-4,5^DB

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Karch et al., 1985)

Progenitor genotype

Caused by aberration

Df(3R)abd-A^iab4,5-DB

Cytology

Description

The Df(3R)abd-A^iab4,5-DB break lies at the 3' end of the iab-4 transcription unit.

(Cumberledge et al., 1990)

DNA deletion from +83 to +113, extending into Abd-B sequences.

(Busturia et al., 1989)

Deletion removes region between coordinates +85 and +113, removing 28kb.

(Karch et al., 1985)

85-113 kb deleted (Karch, Weiffenbach, Peifer, Bender, Duncan, Celniker, Crosby and Lewis, 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Karch et al., 1985)

male sterile | recessive

(Crosby et al., 1993, Karch et al., 1985)

visible | recessive

(Crosby et al., 1993, Karch et al., 1985)

Phenotype Manifest In

gonad | precursor

(Boyle and DiNardo, 1995)

Detailed Description

Statement

Reference

Gonadal precursors do not coalesce into a gonad. Pole cells are released from the stalled gonadal precursors and are scattered throughout the embryo.

(Boyle and DiNardo, 1995)

Segments A6 and A7 show a more posterior identity when heterozygous with Abd-B^- than when hemizygous.

(Hendrickson and Sakonju, 1995)

In homozygous adult males the fifth abdominal segment appears to be partially transformed towards A4.

(Crosby et al., 1993)

Hemizygotes show A1 is slightly modified towards a more posterior segment, transformation is stronger in homozygotes. In males the A5 tergite is depigmented and resembles A4.

(Busturia et al., 1989)

Homozygous males show a transformation of the fourth and fifth abdominal segments into the third.

(Karch et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

D. Baker.

(Karch et al., 1985)

Induced with: iab-4^DB.

(Cumberledge et al., 1990, Karch et al., 1985)

Comments

Mutations in iab-4 have effects on the abd-A transcription unit, so such mutations are considered to be simultaneously mutant for iab-4 and abd-A.

Sterility is complemented by Abd-B^iab5-301, Abd-B^M1 and Abd-B^StP20.

(Crosby et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

abd-A^iab4,5-DB

iab-4,5^DB

(Boyle and DiNardo, 1995, Crosby et al., 1993, Busturia et al., 1989)

iab4,5^DB

(Hendrickson and Sakonju, 1995, Bate, 1993, Sanchez-Herrero, 1991, Karch et al., 1985)

iab5^DB

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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