FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-Biab7-MX2
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General Information
Symbol
Dmel\Abd-Biab7-MX2
Species
D. melanogaster
Name
FlyBase ID
FBal0000130
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Also Known As
iab-7MX2, iab7MX2
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Heuer and Kaufman, 1992, Boulet et al., 1991, Celniker et al., 1990)
Mutagen
X ray
(Kuhn et al., 1993, Karch et al., 1985, Sanchez-Herrero et al., 1985)
Progenitor genotype
Caused by aberration
In(3LR)iab7MX2
Cytology
Description

Molecular lesion lies between coordinates 139.5-142kb.

(Hendrickson and Sakonju, 1995)

Breakpoint maps to between coordinates +139.5 and +142kb.

(Kuhn et al., 1993)

Separates iab-7 region from Abd-B transcription unit.

(Celniker et al., 1990)

Inversion with a breakpoint at about +140 (separates iab-3-iab-7 region from Abd-B transcription unit) (Karch, Cell 43:81-96 ).

(Sanchez-Herrero and Akam, 1989)

Lesion mapped to: 139.5-142 kb.

(Karch et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      Abd-B protein is observed in parasegments 13-15 but not in parasegments 11 and 12 in the ectoderm and in the CNS.

      (Boulet et al., 1991)

      Abd-B transcripts are observed in parasegments 13-15 but not in parasegments 11 and 12.

      (Boulet et al., 1991)

      Abd-B expression is greatly reduced or absent in the epidermis and the ventral nerve cord in parasegments 10-12.

      (Sanchez-Herrero, 1991)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes show an iab5,6,7 mutant phenotype: abdominal segments A5-A7 transform towards A4. Heterozygotes with Abd-B point or pseudopoint mutations cause a less severe mutant phenotype, with mixed A5/A6 identity in A6 and A7. Abd-Biab7-MX2/Df(3R)R59 flies do not show male specific pigmentation in A5-A7.

      (Hendrickson and Sakonju, 1995)

      Transforms parasegments 10--12 into parasegment 9 (FBrf0042053). Hemizygous or homozygous embryos show an anterior boundary in the epidermis and nerve cord that coincides to that of parasegment 13.

      (Sanchez-Herrero, 1991)

      Transforms A5-A7 (parasegments 10-12) into A4 (parasegment 9).

      (Sanchez-Herrero and Akam, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Phenotype over UbxMX12, abd-AM1, Abd-BM8 is the same as when over Abd-B-. The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z.

      (Hendrickson and Sakonju, 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Casanova.

      J. Casanova.

      (Karch et al., 1985)
      Comments
      Comments

      Expression of Abd-B protein and mRNA is limited to parasegments 13-15.

      (Boulet et al., 1991)

      Antibody staining reveals that Abd-Biab7-MX2 has no function in A5-A7.

      (Heuer and Kaufman, 1992)

      m- r+ mutant, with defect in spatial regulation of Abd-B function. No effect on penetrance of head defect phenotype when in trans with Abd-Biab9-tuh-3.

      (Kuhn et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      References (15)