FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-BSab-1
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General Information
Symbol
Dmel\Abd-BSab-1
Species
D. melanogaster
Name
FlyBase ID
FBal0000147
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl nitrosourea
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Single point mutation (G to A, base position 104543 in GenBank accession U31961) in the centre of the IAB5 cis-regulatory module. This mutation is at the fourth position of the highest scoring predicted Kr protein binding site in the IAB5 enhancer, and is predicted to significantly lower the affinity of Kr protein binding.

(Ho et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,878,898..16,878,898 [-]
Nucleotide change:

G16878898A

Comment:

A point mutation in a bioinformatically predicted KRUPPEL TFBS in the IAB5 enhancer.

(Ho et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult abdominal segment 3

      (Ho et al., 2009)

      adult cuticle & abdominal segment 3 | male

      (Kopp et al., 2000)

      adult cuticle & abdominal segment 4 | male

      (Kopp et al., 2000)
      Detailed Description
      Statement
      Reference

      In mutant males, abdominal segment A3 (but not A4) shows additional dark pigmentation, suggesting a transformation towards an A5-like identity.

      (Ho et al., 2009)

      In males homozygous for Abd-BMcp-1,Abd-BSab-1, male specific pigmentation is expanded into A3 and A4.

      (Kopp et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Sakonju.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Abd-BSab-1
      Abd-BSab
      (Kopp et al., 2000)
      Sab
      (Duncan, 1986)
      Sab1
      (Ho et al., 2009)
      Uab4
      Uab4SS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)