FlyBase Allele Report: Dmel\Dr[1]

General Information

Symbol

Dmel\Dr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003107

Feature type

allele

Associated gene

Dmel\Dr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

gain of function allele

(Mozer and Easwarachandran, 1999, Tearle et al., 1994)

Mutagen

X ray

(Mozer, 2001, Krivshenko, 1954)

Progenitor genotype

Cytology

Description

Insertion and additional rearrangements 35kb upstream of the start of Dr transcription.

(Mozer, 2001)

Cytological analysis does not reveal any aberrations.

(Krivshenko, 1954)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior

(Tearle et al., 1994)

lethal | recessive

(Krivshenko, 1954)

lethal - all die during embryonic stage | recessive

(Tearle et al., 1994)

some die during embryonic stage | recessive

(Tearle et al., 1994)

uncoordinated (with Dr^Mio)

(Tearle et al., 1994)

viable (with Df(3R)KE)

(Mozer, 2001)

viable (with Dr^ltt-EMS)

(Mozer, 2001)

visible | adult stage | dominant

(Park et al., 2014)

visible | dominant

(Mozer, 2001, Tearle et al., 1994, Krivshenko, 1954)

Phenotype Manifest In

eye

(Park et al., 2014, Mozer, 2001, Tearle et al., 1994, Krivshenko, 1954)

macrochaeta

(Tearle et al., 1994)

Detailed Description

Statement

Reference

Dr¹ mutant flies exhibit dominant reduced-eye phenotypes that are sensitive to variation in genetic background. The difference in eye size between males and females is similar to that seen in wild type.

(Park et al., 2014)

Heterozygous flies show a normal activity profile in an open field arena over a 10-minute assay.

(Liu et al., 2007)

Heterozygotes show a severe reduction in eye size.

(Mozer, 2001)

Severe disruption of eye development. Heterozygotes with Dr^Mio are semi-lethal, 10-30% adults survive to eclosion, surviving adults exhibit reduced eye, deranged bristle pattern on the thorax, abdomen, legs and wing margins and locomotor defects so the flies could hardly move. A similar phenotype is seen when heterozygous with Dr^Mio revertant alleles and stg alleles. Heterozygotes with Wedge¹ only exhibit the reduced eye phenotype. Interact in trans with lesions in stg causing loss and derangement of bristles and loss of neuromuscular coordination.

(Tearle et al., 1994)

Number of facets varies from 1 to 10. The region of the surface of the eye, which has a red colour, resembles a drop.

(Krivshenko, 1954)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions