FB2024_03 , released June 25, 2024
Allele: Dmel\e4
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General Information
Symbol
Dmel\e4
Species
D. melanogaster
Name
FlyBase ID
FBal0003279
Feature type
allele
Associated gene
Dmel\e
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

448bp deletion in exon I, between nucleotides 623 and 1071 of the e cDNA sequence.

(Perez and Quesada-Allue, 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:21,231,935..21,232,383 [-]
Comment:

448 bp deletion in an exon.

(Perez and Quesada-Allue, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF301896
AAG28774
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      e4 gl2 and e4 wo1 ro1 mutant larvae show an abnormal response to UVC radiation.

      (Baden et al., 1996)

      A large fraction of homozygotes are arrhythmic with respect to locomotor activity when kept in constant darkness at 24oC, and the average signal-to-noise ratio is lower than wild-type. The rhythmicity is not affected by temperature.

      (Newby and Jackson, 1991)

      Spiracle sheaths dark.

      (Brehme, 1941)

      RK1. Body colour: very dark, like e1 but abdomen lighter. period by dark spiracle sheaths.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (170)
      Notes on Origin
      Discoverer

      Sturtevant, 27 Sep. 1917.

      According to Craymer in FBrf0063385, e1 was isolated on In(3R)C and was never successfully separated from it. Most ebony alleles denoted simply as "e" without a specific allele designation can be traced back to Muller's e4. Most ebony mutations in Stock Center stocks designated as e1 are probably e4.

      (Kennison and Cook, 2008.11.20)
      Comments
      Comments

      Most viable and generally best of the dark alleles, such as e1 and e11. Classifiable from hatching throughout larval

      Stocks labeled as carrying 'e', but not In(3R)C, usually have e4.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      e4
      (Kennison and Cook, 2008.11.20)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)