FB2024_03 , released June 25, 2024
Allele: Dmel\ems4
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General Information
Symbol
Dmel\ems4
Species
D. melanogaster
Name
FlyBase ID
FBal0003715
Feature type
allele
Associated gene
Dmel\ems
Associated Insertion(s)
Carried in Construct
Also Known As
ems10A37, ems10A
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Dalton et al., 1989)
Mutagen
ethyl methanesulfonate
(Walldorf and Gehring, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

There is a base pair change of G to A in helix 3 of the homeobox, which changes tryptophan at position 48 of the homeobox to a stop codon.

(Walldorf and Gehring, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,903,772..13,903,772 [+]
Nucleotide change:

G13903772A

Reported nucleotide change:

G?A

Amino acid change:

W435term | ems-PA

Reported amino acid change:

W?term

(Walldorf and Gehring, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No effect on prd expression in embryo.

      (Gutjahr et al., 1993)

      Partial head involution occurs in homozygous embryos. Some head structures derived from the pre-antennal, antennal and intercalary segments are missing, such as the dorsal arms, vertical plates, lateralgraten and antennal sense organs. The dorsal bridge, ventral arms and posterior wall of the pharynx are an abnormal shape. The posterior spiracles are devoid of Filzkorper.

      (Walldorf and Gehring, 1992)

      Does not interact with RpII140wimp maternal effect.

      (Parkhurst and Ish-Horowicz, 1991)

      Most embryos display absence of head structures.

      (Dalton et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Jurgens, Wieschaus, Nusslein-Volhard and Kluding, 1984.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (10)