FlyBase Allele Report: Dmel\ftz[13]

General Information

Symbol

Dmel\ftz¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0004818

Feature type

allele

Associated gene

Dmel\ftz

Associated Insertion(s)

Carried in Construct

Also Known As

ftz^9H34

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Copeland et al., 1996, Jost et al., 1995, Cadigan et al., 1994, Furukubo-Tokunaga et al., 1992, Limbourg-Bouchon et al., 1991)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | partially | heat sensitive (with ftz⁵)

(Kankel et al., 2004)

lethal | recessive

(Howard and Ingham, 1986)

Phenotype Manifest In

Detailed Description

Statement

Reference

ftz¹³/+ first instar larvae only rarely have segmentation defects.

(Bullock et al., 2004)

At 26.5^oC, about 64% of ftz⁵/ftz¹³ animals survive to adulthood, while at 27.5^oC, about 35% survive to adulthood. At 26.5^oC, ftz⁵/ftz¹³ embryos show variable segmentation phenotypes, ranging from normal to having defects in three ftz-dependent denticle belts. At 27.5^oC, 53.8% of ftz⁵/ftz¹³ embryos have segment defects, with 4.3% having 3 ftz-dependent segments affected.

(Kankel et al., 2004)

Homozygous embryos lack the odd-numbered abdominal segments.

(Kennerdell and Carthew, 1998)

Mutant embryos are deficient for cuticular structures derived from the even numbered parasegments.

(Hyduk and Percival-Smith, 1996)

P{ftzK}; ftz¹³ embryos fail to express ftz in the CNS and have a normal or only mildly defective epidermal development (FBrf0049007).

(Yeo et al., 1995)

Subtle reduction in rate of germ band extension.

(Irvine and Wieschaus, 1994)

The phenotype of fu⁴¹ ftz¹³ double mutants can be interpreted as an addition of the corresponding single mutant phenotypes.

(Limbourg-Bouchon et al., 1991)

Shows an extreme ftz phenotype when homozygous and in trans with ftz¹⁴.

(Maier et al., 1990)

Double mutants with prd⁴ display a complete lack of segmentation.

(Tremml and Bienz, 1989)

P{ftzK}; ftz¹¹/ftz¹³ individuals die as embryos or larvae. 66% of P{ftzG}; ftz¹¹/ftz¹³ individuals survive to adulthood. P{ftzK}; ftz¹¹/ftz¹³ embryos are identified by weak segmentation defects in the CNS.

(Doe et al., 1988)

Odd numbered denticle bands missing.

(Jack et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)1427[+]/E(ftz)1427¹⁴²⁷

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)1815¹⁸¹⁵/E(ftz)1815[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)1819¹⁸¹⁹/E(ftz)1819[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)20²⁰/E(ftz)20[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)2142[+]/E(ftz)2142²¹⁴²

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)2828²⁸²⁸/E(ftz)2828[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4236[+]/E(ftz)4236⁴²³⁶

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)2955²⁹⁵⁵/E(ftz)2955[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)3150[+]/E(ftz)3150³¹⁵⁰

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)3201³²⁰¹/E(ftz)3201[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4038[+]/E(ftz)4038⁴⁰³⁸

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4758[+]/E(ftz)4758⁴⁷⁵⁸

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)5303⁵³⁰³/E(ftz)5303[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug³³³³/Gug[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by bek¹/bek[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f1[+]/ftz-f1³⁴⁴³

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable by E(ftz)723[+]/E(ftz)723⁷²³

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f1[+]/ftz-f1⁵³⁰⁸

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by hth²²³²/hth[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f1²⁴⁷⁸/ftz-f1[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by eIF4E1²¹⁸⁸/eIF4E1[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable by how[+]/how²⁴⁵⁵

(Kankel et al., 2004)

ftz⁵/ftz¹³ has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)1027¹⁰²⁷/E(ftz)1027[+]

(Kankel et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

ftz¹³ has embryonic/first instar larval cuticle phenotype, enhanceable by egl^3e/egl¹

(Bullock et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)1815¹⁸¹⁵/E(ftz)1815[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)1819¹⁸¹⁹/E(ftz)1819[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)20²⁰/E(ftz)20[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)2142[+]/E(ftz)2142²¹⁴²

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)2955²⁹⁵⁵/E(ftz)2955[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)3150[+]/E(ftz)3150³¹⁵⁰

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)3201³²⁰¹/E(ftz)3201[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)4038[+]/E(ftz)4038⁴⁰³⁸

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)723[+]/E(ftz)723⁷²³

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by Gug³³³³/Gug[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by bek¹/bek[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by ftz-f1[+]/ftz-f1³⁴⁴³

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by ftz-f1[+]/ftz-f1⁵³⁰⁸

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by hth²²³²/hth[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by ftz-f1²⁴⁷⁸/ftz-f1[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, enhanceable by E(ftz)1427[+]/E(ftz)1427¹⁴²⁷

(Kankel et al., 2004)

Suppressed by

Statement

Reference

ftz⁵/ftz¹³ has embryonic segment phenotype, suppressible by E(ftz)4236[+]/E(ftz)4236⁴²³⁶

(Kankel et al., 2004)

ftz⁵/ftz¹³ has embryonic segment phenotype, suppressible by how[+]/how²⁴⁵⁵

(Kankel et al., 2004)

Enhancer of

Statement

Reference

ftz[+]/ftz¹³ is an enhancer of embryonic segment | maternal effect | germline clone phenotype of bek¹

(Kankel et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of cuticular segmentation phenotypes in ftz¹³/+ first instar larvae is significantly enhanced in animals with a egl^3e/egl¹ mutant mother.

(Bullock et al., 2004)

The segmentation defects seen in ftz⁵/ftz¹³ embryos at 27.5^oC are dominantly enhanced by the following (in each case the % of embryos with segmentation defects followed by the % of embryos with at least 3 ftz-dependent segments affected are given in parentheses after the enhancing allele); ftz-f1²⁴⁷⁸ (95.9%, 44.7%), ftz-f1³⁴⁴³ (98.5%, 35.1%), ftz-f1⁵³⁰⁸ (91.3%, 40.5%), Gug⁵¹⁹ (100%, 90.2%), Gug¹⁷⁵⁷ (89.7%, 55.1%), Gug³³³³ (98.7%, 98.0%), bek¹ (92.5%, 61.9%), hth²²³² (73.9%, 16.3%), E(ftz)20²⁰ (72.4%, 11.2%), E(ftz)723⁷²³ (91.9%, 32.5%), E(ftz)1427¹⁴²⁷ (99.4%, 93.1%), E(ftz)1815¹⁸¹⁵ (72.1%, 22.1%), E(ftz)1819¹⁸¹⁹ (97.8%, 31.3%), E(ftz)2142²¹⁴² (93.1%, 13.2%), E(ftz)2955²⁹⁵⁵ (78.5%, 16.2%), E(ftz)3150³¹⁵⁰ (95.0%, 79.4%), E(ftz)3201³²⁰¹ (88.7%, 15.5%), E(ftz)4038⁴⁰³⁸ (82.9%, 23.6%). how²⁴⁵⁵ dominantly suppresses the segmentation defects seen in ftz⁵/ftz¹³ embryos at 27.5^oC; 26.2% of the embryos have segment defects and 1.5% have at least 3 ftz-dependent segments affected. E(ftz)4236⁴²³⁶ dominantly suppresses the segmentation defects seen in ftz⁵/ftz¹³ embryos at 27.5^oC; 39.0% of the embryos have segment defects and 1.2% have at least 3 ftz-dependent segments affected. The frequency of segmentation defects seen in embryos derived from a cross of bek¹/+ males to females carrying homozygous bek¹ germline clones is increased if the fathers also carry ftz¹³.

(Kankel et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ftz¹³ is rescued by ftz^K

(Heffer et al., 2013)

ftz¹³ is rescued by ftz^NE

(Heffer et al., 2013)

ftz¹³ is rescued by ftz^NE.LRAAA

(Heffer et al., 2013)

ftz¹³ is rescued by ftz^NE.AAAA

(Heffer et al., 2013)

ftz¹³ is rescued by Antp::ftz^ftzAntpHD.NE

(Heffer et al., 2013)

ftz¹³ is rescued by ftz::Tcas\ftz^ftzTcHD.NE

(Heffer et al., 2013)

ftz¹¹/ftz¹³ is rescued by ftz^+tDa

(Dong et al., 1998)

Partially rescued by

ftz¹³ is partially rescued by ftz::Asal\ftz^ftzAsHD.NE

(Heffer et al., 2013)

ftz¹¹/ftz¹³ is partially rescued by ftz^{Δ257-316.αTub84B}

(Argiropoulos et al., 2003)

ftz¹¹/ftz¹³ is partially rescued by ftz^αTub84B.PA

(Argiropoulos et al., 2003)

ftz¹¹/ftz¹³ is partially rescued by ftz^T263D

(Dong et al., 1998)

Not rescued by

ftz¹³ is not rescued by Antp::ftz^ftzNTAntp.NE

(Heffer et al., 2013)

ftz¹³ is not rescued by ftz^ΔHD.NE

(Heffer et al., 2013)

ftz¹¹/ftz¹³ is not rescued by ftz^T263A

(Dong et al., 1998)

Comments

Expression of ftz^K in a ftz¹³ background rescues the segmentation defects but does not rescue CNS function, as illustrated by the RP2 neurons, which fail to develop.

(Heffer et al., 2013)

21 to 71% of ftz¹¹/ftz¹³ flies are rescued to adulthood by ftz^+tDa. 2 to 5% of ftz¹¹/ftz¹³ flies are rescued to adulthood by ftz^T263D. Larval cuticles of ftz¹¹/ftz¹³ animals rescued by ftz^T263D are indistinguishable from wild-type. ftz¹¹/ftz¹³ flies are not rescued to adulthood by ftz^T263A. Larval cuticles of ftz¹¹/ftz¹³ animals carrying ftz^T263A have pair-wise deletions of even-numbered parasegments. The penetrance of the phenotype is variable and defects in each ftz-dependent parasegment (PS) occur with a characteristic frequency. These range from the most to least frequently affected as follows: PS2 > PS6 > PS10 = PS4 > PS12 = PS14 > PS8.

(Dong et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5332

P{ftz-lacC}1, ftz¹³/TM3, Sb¹

5336

P{ftz-lacC}4; ftz¹³ ry⁵⁰⁶ e^s/TM3, Sb¹

Notes on Origin

Discoverer

Jurgens.

Comments

Removes even numbered en stripes.

(Tremml and Bienz, 1989)

Mutant phenotype of the ftz¹³/ftz¹⁴ heterozygote can be rescued to adulthood by the P{ftz4} construct. Partial rescue is seen with P{ftz5} construct and its revertants and no rescue with the P{ftzΔHD} construct.

(Furukubo-Tokunaga et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

FBal0004830

References (38)

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