FB2024_03 , released June 25, 2024
Allele: Dmel\H20
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General Information
Symbol
Dmel\H20
Species
D. melanogaster
Name
FlyBase ID
FBal0005311
Feature type
allele
Associated gene
Dmel\H
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Bang and Posakony, 1992)
Mutagen
gamma ray
(Bang et al., 1991)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Bang et al., 1991)
Description

Inversion of a 2kb fragment with both breakpoints within the H coding region.

(Bang and Posakony, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The bristle loss phenotype of H20/HE31 can be suppressed by deleting components of the E(spl)-complex. The degree of suppression depends on both the number and identity of E(spl)-complex transcription units removed. Rescued bristles display a double socket phenotype. Clonal analysis revealed that the gro mutant bristle tufting phenotype is epistatic to the H null bristle loss phenotype.

      (Bang et al., 1995)

      Bristle loss on head and notum and double socket phenotype.

      (Bang et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      H20 is a suppressor of phenotype of Brdunspecified

      (Bang et al., 1991)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominant suppressor of Brd: due to haploinsufficiency.

      (Bang et al., 1991)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Posakony/Groger.

      Comments
      Comments

      Strong H allele.

      (Bang et al., 1991)

      Phenotypic series of H alleles correlates with severity of molecular defects: in order of decreasing severity H18 = H20 > H21 > HD179.

      (Bang and Posakony, 1992)

      H20/HE31 is used as the standard null genotype.

      (Bang et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      H20
      HC28
      (Bang et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)