FlyBase Allele Report: Dmel\H[21]

General Information

Symbol

Dmel\H²¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005312

Feature type

allele

Associated gene

Dmel\H

Associated Insertion(s)

Carried in Construct

Also Known As

H²², H^RP1, H^C23

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bang et al., 1995, Bang and Posakony, 1992, Bang et al., 1991)

Mutagen

gamma ray

(Bang et al., 1991)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Bang et al., 1991)

Description

Truncation of the C terminal 69 amino acids with six additional amino acids added due to frame shift.

(Maier et al., 1997)

304bp genomic SpeI fragment deleted, indicating that at least 19 amino acids are removed from the carboxy terminus of the H protein.

(Bang and Posakony, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Barolo et al., 2002, Barolo et al., 2000, Nagel et al., 2000, Bang and Posakony, 1992)

visible | recessive

(Kavaler et al., 1999)

Phenotype Manifest In

eo neuron

(Nagel et al., 2000)

macrochaeta

(Barolo et al., 2002, Bang et al., 1995)

microchaeta & trichogen cell

(Kavaler et al., 1999)

thecogen cell | ectopic

(Nagel et al., 2000)

tormogen cell | ectopic

(Barolo et al., 2000, Nagel et al., 2000)

trichogen cell

(Barolo et al., 2000, Nagel et al., 2000)

Detailed Description

Statement

Reference

Homozygotes show loss of bristle shafts.

(Barolo et al., 2002)

Homozygous flies show shaft-to-socket cell transformations.

(Barolo et al., 2000)

H²¹ homozygotes exhibit an incomplete transformation of the external sensory organ shaft cell into a socket and the neuron into the sheath cell.

(Nagel et al., 2000)

Almost all microchaetae show a double socket phenotype in homozygous adults.

(Kavaler et al., 1999)

The bristle loss phenotype of H²¹/H²¹ can be suppressed by deleting components of the E(spl)-complex. The degree of suppression depends on both the number and identity of E(spl)-complex transcription units removed. Rescued bristles are wild type.

(Bang et al., 1995)

Homozygous viable.

(Bang and Posakony, 1992)

Occasionally a double socket appears on the head in the position of the postvertical macrochaetae. Failure of sensillum precursor development.

(Bang et al., 1991)

Less severe than H¹⁶. Almost completely recessive. Heterozygotes most frequently wildtype in phenotype, but occasionally a 'double socket' appears on the head in the position of a postvertical macrochaete or on the abdominal tergites. Homozygotes display a much stronger and more extensive mutant phenotype than H null heterozygotes. Many head and notum macrochaetes and approximately 50% of notum microchaetes missing; remaining 50% exhibit a spectrum of 'double socket' phenotypes. Homozygotes also exhibit loss of wing vein tissue from L4 and L5. Approximately 50% of flies carrying H²¹ in trans to a H null allele die as pharate adults. The remainder survive to eclosion, but are short-lived and exhibit extensive loss of both macrochaetes and microchaetes on the head, notum and abdominal tergites; only 20% of the notum microchaetes remain, all with a completely transformed 'double socket' phenotype.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

H²¹ has visible phenotype, enhanceable by gro^E73/gro[+]

(Barolo et al., 2002)

NOT Enhanced by

Statement

Reference

H²¹ has visible phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

H²¹, gro^E73/gro[+] has visible phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

NOT suppressed by

Statement

Reference

H²¹, gro^E73/gro[+] has visible phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

H²¹ has visible phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

H²¹ has macrochaeta phenotype, enhanceable by gro^E73/gro[+]

(Barolo et al., 2002)

NOT Enhanced by

Statement

Reference

H²¹ has macrochaeta phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

H²¹, gro^E73/gro[+] has macrochaeta phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

NOT suppressed by

Statement

Reference

H²¹, gro^E73/gro[+] has macrochaeta phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

H²¹ has macrochaeta phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

Suppressor of

Statement

Reference

H²¹ is a suppressor of phenotype of Brd¹

(Bang et al., 1991)

Additional Comments

Genetic Interactions

Statement

Reference

Dominant suppressor of Brd: due to haploinsufficiency.

(Bang et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

93661

H²¹

Notes on Origin

Discoverer

Posakony/Groger.

Comments

H²¹ and "H²²" found to be same allele (FBrf0056117).

Weak H allele.

(Bang et al., 1991)

Same molecular lesion found for H²²: authors conclude that these two lines include the same mutant allele. Phenotypic series of H alleles correlates with severity of molecular defects: in order of decreasing severity H¹⁸ = H²⁰ > H²¹ > H^D179.

(Bang and Posakony, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

H²¹

H²²

(Praxenthaler et al., 2015, Barolo et al., 2002, Nagel et al., 2000, Maier et al., 1997, Bang et al., 1995, Bang and Posakony, 1992)

H^C23

(Leviten and Posakony, 1996, Bang and Posakony, 1992, Bang et al., 1991)

H^RP1

(Barolo et al., 2000, Lyman and Yedvobnick, 1995, Bang and Posakony, 1992, Bang et al., 1991)

Name Synonyms

Secondary FlyBase IDs

FBal0005313

References (11)

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