FB2024_03 , released June 25, 2024
Allele: Dmel\Lim37
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General Information
Symbol
Dmel\Lim37
Species
D. melanogaster
Name
FlyBase ID
FBal0008654
Feature type
allele
Associated gene
Dmel\Lim3
Associated Insertion(s)
Carried in Construct
Also Known As
lim3Bd7, Bd7
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Black et al., 1987)
gamma ray
(Black et al., 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G749A. Amino acid replacement: C?Y. Mutation falls in the second LIM domain. The C functions in the coordination of Zn ions and is conserved in all known LIM domains.

(Thor et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,081,524..19,081,524 [-]
Nucleotide change:

G19081524A

Reported nucleotide change:

G749A

Amino acid change:

C152Y | Lim3-PA; C232Y | Lim3-PB; C232Y | Lim3-PC; C232Y | Lim3-PD; C117Y | Lim3-PE; C232Y | Lim3-PF; C232Y | Lim3-PG

Reported amino acid change:

C?Y

(Thor et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      cuticle & abdomen & pharate adult

      (Wright, 1996)

      cuticle & head & pharate adult

      (Wright, 1996)

      cuticle & thorax & pharate adult

      (Wright, 1996)

      melanotic mass | pharate adult stage

      (Wright, 1996)
      Detailed Description
      Statement
      Reference

      Lim34/Lim37 pharate adults have regions of undifferentiated cuticle on the head, thorax and abdomen, and have melanotic tumours.

      (Wright, 1996)

      Less than 1% of hemizygous Lim37/Df(2L)TW130 animals survive to the third larval instar stage.

      (McCrady and Tolin, 1994)

      strong allele in which second and third instar larvae persist until days eight and nine; more survive to pharate-adult stage with incomplete sclerotization than in the case of either Lim32 or Lim36. Lim34/Lim37 phenotype similar to that of Lim37

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Wright.

      Comments
      Comments

      Weak allele.

      (Thor et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Bd7
      (Thor et al., 1999, Wright, 1996)
      Lim37
      l(2)37Bd7
      (Stathakis et al., 1995)
      l(2)7408
      lim3Bd7
      (Santiago and Bashaw, 2017, Thor et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)