FB2024_03 , released June 25, 2024
Allele: Dmel\mbmC1
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General Information
Symbol
Dmel\mbmC1
Species
D. melanogaster
Name
FlyBase ID
FBal0012107
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
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Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
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Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
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Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
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Disease
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Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mushroom body calyces in mbmN337 mutants are reduced to approximately 20-50% volume of wild-type flies. Gross brain morphology appears relatively normal.

mbmC1 heterozygous flies demonstrate comparable patterns of landmark orientation, indicating similar responses to visual stimulation in Buridan's paradigm as control flies.

mbmC1 heterozygous flies exhibit reduced activity levels and walk slower than control flies.

Flies have a number of brain defects, the exact phenotype depending on the genetic background. In the original genetic background in which it was induced, mbmC1 produces the following phenotype; the calyx is 1/4 normal size, the peduncle and lobes are thin or absent, the antennal lobe is reduced, the ellipsoid body is open ventrally and the noduli are often misshapen. When placed in a Canton S background, the phenotype is similar to that in the original genetic background, although the central complex defects are less penetrant.

Calyces, pedunculi and lobes, and antennal lobes are small.

Phenotype similar to that of mbm; also, the pair of antennal lobes differ in volume in most mbmC adults (i.e. left smaller than right, or vice versa); learning very poor in tests of females, using olfactory stimuli.

External Data
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Mutant
Wild-type
Stocks (1)
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Synonyms and Secondary IDs (2)
Reported As
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Name Synonyms
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    References (3)