FlyBase Allele Report: Dmel\mei-41[D14]

General Information

Symbol

Dmel\mei-41^D14

Species

D. melanogaster

Name

FlyBase ID

FBal0012165

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

Also Known As

mei-41^104D1, mus104^D1, mus(1)104^D1

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: L655F.

(Laurencon et al., 2003)

In addition to the L655F amino acid replacement, which may cause the mutant phenotype, a number of additional amino acid changes are present compared to the U34925 mei-41 GenBank sequence (these "common" mutations are also present in other mei-41 mutant alleles, possibly due to variability present in the mutagenised population).

(Laurencon et al., 2003)

Nucleotide substitution: G4339T.

(Laurencon et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:16,394,330..16,394,330 [+]

Nucleotide change:

G16394330T

Reported nucleotide change:

G4339T

Amino acid change:

L818F | mei-41-PA

Reported amino acid change:

L655F

Comment:

The mutation site reported in FBrf0160718 is relative to GB:U34925 (in which the predicted CDS is missing 163 N-terminal amino acids relative to genome release 3.2). Other amino acid changes common to several mei-41 mutants are also present in the strain (see FBrf0160718).

(Laurencon et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal DNA repair

(Todo and Ryo, 1992)

chemical sensitive

(Olsen and Green, 1982)

female fertile

female semi-sterile

(Laurencon et al., 2003)

viable

(Laurencon et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

55% of eggs derived from homozygous females hatch into larvae. Hemizygous larvae show a G₂/M checkpoint that is robust as in wild-type.

(Laurencon et al., 2003)

Mutations is proficient in excision repair but defective in post-replicative repair of UV damage (FBrf0028765).

(Todo and Ryo, 1992)

Flies are not sensitive to X rays.

(Oliveri et al., 1990)

Homozygotes and hemizygotes do not show an increased frequency of spontaneous chromosome aberrations in neuroblast metaphases compared to wild-type larvae.

(Gatti, 1979)

Does not reduce meiotic exchange.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference