FlyBase Allele Report: Dmel\Pc[3]

General Information

Symbol

Dmel\Pc³

Species

D. melanogaster

Name

FlyBase ID

FBal0013553

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Soto et al., 1995, Zink et al., 1991)

antimorphic allele - genetic evidence

(Gindhart and Kaufman, 1995, Muller et al., 1995, Simon et al., 1992, McKeon and Brock, 1991, Capdevila et al., 1986)

Mutagen

ethyl methanesulfonate

(Capdevila et al., 1986, Lewis, 1980)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | embryonic stage

(Prokop et al., 1998)

homeotic

(Fresán et al., 2020, Lagarou et al., 2008)

homeotic | adult stage | dominant | male

(Bi et al., 2022)

homeotic | dominant

(Orsi et al., 2014)

homeotic | dominant | male

(Rincon-Arano et al., 2012)

homeotic | embryonic stage

(Dutta and Li, 2017)

increased cell number | embryonic stage

(Dutta and Li, 2017)

increased occurrence of cell division | embryonic stage

(Prokop et al., 1998)

lethal | recessive

(Capdevila et al., 1986)

lethal - all die during embryonic stage | recessive

(Busturia et al., 1997, Tiong and Russell, 1990)

some die during embryonic stage | recessive

(Busturia et al., 1997, Tiong and Russell, 1990)

suppressor of variegation, with P{UAS-lacZ.Abd-B.24F6}GCD-6/+:

(Canudas et al., 2005)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M3

(Mallin et al., 1998)

visible

(Kodjabachian et al., 1998)

visible | adult stage | dominant | male

(Bi et al., 2022)

visible | dominant

(Orsi et al., 2014, Tie et al., 2009, Parrish et al., 2007, Gutierrez et al., 2003, Schwendemann and Lehmann, 2002, Strutt et al., 1997, Castelli-Gair and Garcia-Bellido, 1990, Tiong and Russell, 1990, Duncan, 1982)

visible | dominant | homeotic

(Ogasawara et al., 2007, Furuyama et al., 2004, Busturia et al., 2001, Sedkov et al., 1999, Bornemann et al., 1998)

visible | dominant | homeotic | heat sensitive

(Sinclair et al., 1984)

visible | embryonic stage

(Dutta and Li, 2017)

visible | homeotic

(Chen et al., 2005, van der Knaap et al., 2005)

Phenotype Manifest In

abdominal segment

(Lagarou et al., 2008)

abdominal segment 4 | male

(van der Knaap et al., 2005)

abdominal segment 5 | ectopic | male

(van der Knaap et al., 2005)

abdominal tergite 4 | male

(Ogasawara et al., 2007)

adult abdominal segment 1

(Duncan, 1982)

adult abdominal segment 4

(Duncan, 1982)

adult abdominal segment 4 | male

(Ogasawara et al., 2007)

adult abdominal segment 5

(Duncan, 1982)

adult abdominal segment 5 | ectopic | male

(Ogasawara et al., 2007)

adult abdominal segment 6

(Duncan, 1982)

adult external mesothorax

(Song et al., 2007)

adult external prothorax | ectopic

(Song et al., 2007)

antenna

(Busturia et al., 2001, Sedkov et al., 1999, Duncan, 1982)

embryonic/larval brain | embryonic stage

(Jimenez and Campos-Ortega, 1981)

embryonic abdominal segment

(Choi et al., 2000)

embryonic abdominal segment 5

(Chen et al., 2005)

embryonic abdominal segment 6

(Chen et al., 2005)

embryonic abdominal segment 7

(Chen et al., 2005)

embryonic midgut constriction

(McKeon and Brock, 1991)

embryonic thoracic segment

(Choi et al., 2000)

genital disc primordium | ectopic

(Chen et al., 2005)

gonadal sheath proper primordium (with Pc¹⁵)

(DeFalco et al., 2004)

haltere | ectopic

(Song et al., 2007)

haltere | ectopic | female

(van der Knaap et al., 2005)

leg | ectopic

(Busturia et al., 2001, Sedkov et al., 1999)

mesothoracic leg

(Orsi et al., 2014, Parrish et al., 2007, Furuyama et al., 2004, Gutierrez et al., 2003, Schwendemann and Lehmann, 2002, Busturia et al., 2001, Strutt et al., 1997, Tiong and Russell, 1990, Duncan, 1982)

mesothoracic leg & sex comb | ectopic

(Strutt et al., 1997, Sinclair et al., 1984)

mesothoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

mesothoracic leg | male

(Bi et al., 2022, van der Knaap et al., 2005)

mesothoracic segment

(Sato and Denell, 1985)

metathoracic leg

(Orsi et al., 2014, Tie et al., 2009, Parrish et al., 2007, Gutierrez et al., 2003, Schwendemann and Lehmann, 2002, Busturia et al., 2001, Duncan, 1982)

metathoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

metathoracic leg | male

(Bi et al., 2022)

metathoracic segment

(Sato and Denell, 1985)

presumptive embryonic/larval central nervous system

(Prokop et al., 1998, Jimenez and Campos-Ortega, 1981)

prothoracic leg | ectopic | male

(Bi et al., 2022, van der Knaap et al., 2005)

sex comb

(Strübbe et al., 2011, Lagarou et al., 2008, Kodjabachian et al., 1998)

sex comb | ectopic

(Orsi et al., 2014, Tie et al., 2009, Chalkley et al., 2008, Parrish et al., 2007, Furuyama et al., 2004, Gutierrez et al., 2003, Schwendemann and Lehmann, 2002, Busturia et al., 2001, Mollaaghababa et al., 2001, Strutt et al., 1997)

sex comb | ectopic | male

(Rincon-Arano et al., 2012, van der Knaap et al., 2005)

sternopleural bristle

(Song et al., 2007)

ventral denticle belt | embryonic stage

(Dutta and Li, 2017)

ventral mesothoracic disc primordium

(Chen et al., 2005)

wing

(Bi et al., 2022, Lagarou et al., 2008, Song et al., 2007, Castelli-Gair and Garcia-Bellido, 1990, Tiong and Russell, 1990, Duncan, 1982)

wing | female

(van der Knaap et al., 2005)

wing blade

(Bi et al., 2022)

Detailed Description

Statement

Reference

Pc³/+ adults exhibit sex combs on the second and third pairs of legs of male flies, and a defective wing development indicative of a wing to haltere transformation.

(Fresán et al., 2020)

Denticle belts of Pc³ homozygous embryos exhibit homeotic transformation of all other abdominal segments into segment A8.

Pc³ homozygotes exhibit an increased number of cells expressing engrailed in a stripe during embryonic development at germ-band extension.

(Dutta and Li, 2017)

Heterozygous males have ectopic sex combs on the second leg (55% penetrance) and on the third leg (15% penetrance).

(Orsi et al., 2014)

40% of heterozygous males have homeotic transformations of the second and third legs into the first leg (score by the presence of a sex comb on the second and/or third leg).

(Rincon-Arano et al., 2012)

36% of heterozygous males raised at 29[o]C have sex comb bristles on the T3 legs.

(Tie et al., 2009)

Males heterozygous for Pc¹ exhibit posterior-to-anterior leg transformation, readily visualized by the ectopic appearance of sex combs on the second or both the second and third legs.

(Chalkley et al., 2008)

Heterozygous adults display the following homeotic transformations: sex combs on the second and/or third leg, transformation of the fourth abdominal segment into the semblance of the posterior fifth and defective wing development indicative of wing-to-haltere transformation.

(Lagarou et al., 2008)

59.2% of heterozygous males show ectopic pigmentation of the A4 tergite, representing posterior transformation (A4 to A5).

(Ogasawara et al., 2007)

Heterozygous males have ectopic sex combs on the second and third legs.

(Parrish et al., 2007)

One of the characteristics of Pc³ heterozygous mutants is the loss of sternopleural bristles due to the transformation of the second thoracic segment to a first thoracic segment. Another phenotype is a partial wing-to-haltere transformation

(Song et al., 2007)

Pc³ males have ectopic sex combs on the second and third leg.

(Ragab, 2006)

The anterior thoracic and abdominal segments A5-A7 develop with characteristics of posterior A7 and anterior A8 in Pc³ mutant embryos. At stage 15 of development, these transformed segments contain ~9 ectopic, ventrally located genital disc precursor cells and the leg disc precursor cells are absent.

(Chen et al., 2005)

Ectopic male-specific somatic gonadal precursor (msSGP) cells are seen in both male and female Pc³/Pc¹⁵ embryos before gonad coalescence. Normal and ectopic non-sexually dimorphic somatic gonadal precursor cell (SGP) specification is also seen in these mutant embryos. At later stage in mutant male embryos, a large number of ectopic msSGPs associate with SGPs and germ cells to form a gonad. However, in most mutant female embryos msSGPs are no longer seen at later stages.

(DeFalco et al., 2004)

33-36% of T2 legs and 0% of T3 legs have sex combs in heterozygous males.

(Furuyama et al., 2004)

100% of heterozygous males have sex comb teeth on the second and/or third leg. Expressivity of the phenotype is 52%.

(Gutierrez et al., 2003)

The frequency of breaks in the polytene chromosomes of heterozygous larvae is normal.

(Zhimulev et al., 2003)

Pc³ heterozygous flies exhibit ectopic sex combs on the mesothoracic and metathoracic legs at a low penetrance.

(Schwendemann and Lehmann, 2002)

7% of heterozygotes have extra sex combs (on the 2nd or 3rd leg) and 8% of heterozygotes show transformation of antenna to leg.

(Busturia et al., 2001)

Heterozygotes do not show transformation of abdominal segment 6 to abdominal segment 7. There is an average of 0.3 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male).

(Mollaaghababa et al., 2001)

Homozygous embryos show strong transformation of all the thoracic and abdominal segments to more posterior abdominal segments.

(Choi et al., 2000)

34.4% of heterozygous males show transformation of antenna to leg.

(Sedkov et al., 1999)

The pattern of BrdU incorporation in the central nervous system is abnormal in homozygous stage 16/17 embryos; the lateral sites of BrdU incorporation are abolished, and ectopic sites of BrdU incorporation are seen ventrally.

(Prokop et al., 1998)

Does not affect the position effect variegation (PEV) at the w locus caused by In(1)w^m4 or PEV at the B locus caused by Dp(1;Y)B^SCV.

(Sinclair et al., 1998)

Heterozygous males have ectopic sex combs on the second leg.

(Strutt et al., 1997)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

The loss of the zygotic Pc causes a severe transformation of most segments towards parasegment 8 (Lewis, Nature 276: 565-570, Duncan, Developmental Order, pp 533--554, New York).

(Simon et al., 1992)

lab expression in midgut (as indicated by lab-Ecol\lacZ fusion genes) extended anteriorly.

(Tremml and Bienz, 1992)

Lack midgut constrictions.

(McKeon and Brock, 1991)

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Extra sex combs phenotype.

(Pattatucci and Kaufman, 1991)

Ectopic sex comb teeth in males.

(Pattatucci et al., 1991)

Pc³, Df(3L)Pc embryos have a cuticle phenotype in which each segment is transformed toward a segment with characteristics of the posterior seventh and anterior eighth abdominal segments. The transformation is often not complete in the head or thorax. In Pc^- mutant embryos the en reporter gene expression was incompletely repressed creating discs that had a morphology like that of genital discs with thick ridges and Ba expression is indistinguishable from wild type.

(Simcox et al., 1991)

Heterozygotes have partial transformation of wing to metathorax. This phenotype is abolished in flies also carrying a Ubx mutation in the coding region or abx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

In double mutants Pc³, fs(1)N¹² all abdominal segments are transformed to the eighth abdominal segment.

(Degelmann et al., 1990)

Heterozygous adults show transformations of 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.

(Tiong and Russell, 1990)

Transformation of anterior segments to the 8th abdominal segment.

(Capdevila et al., 1986)

Homozygous embryos show variable transformation of the mesothoracic denticle belt and anterior-most dorsal spinules to resemble those of more posterior segments. There is also an anterior transformation of some mesothoracic cuticle structures, such as a reduction in spinule density on the dorsal surface. A similar transformation is seen in the metathorax. Homozygous Pc³ embryos that are also hemizygous for Scr^- have enhanced posterior transformation of posterior portions of the head, prothorax, and mesothorax.

(Sato and Denell, 1985)

Heterozygous males have extra sex combs on the second legs. The penetrance of this phenotype is 96.4% at 22^oC and 100% at 29^oC.

(Sinclair et al., 1984)

Heterozygous adults often show partial transformations of antenna to leg, second and third leg to first leg, and wing to haltere. Transformation of the first, fourth, fifth and sixth abdominal segments to more posterior segments are also seen.

(Duncan, 1982)

Homozygous embryos have defects in the brain and ventral cord regions of the central nervous system. The supraesophageal ganglia are strongly reduced, especially where they connect to the subesophageal ganglia, and the intracortical cell bands are absent from all neuromeres.

(Jimenez and Campos-Ortega, 1981)

RK2.

(Lewis, 1980)

partial transformations of second and third legs into first legs in Pc/+ heterozygotes Sex combs of males are larger and resemble those of Scx.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pc³ has homeotic phenotype, enhanceable by Haspin¹²⁸/Haspin¹²⁸

(Fresán et al., 2020)

Pc³ has homeotic phenotype, enhanceable by Scer\GAL4^Act5C.PU/Haspin^GL00176

(Fresán et al., 2020)

Haspin¹²⁸, Pc³ has homeotic phenotype, enhanceable by vtd^ex3

(Fresán et al., 2020)

Haspin¹²⁸, Pc³ has homeotic phenotype, enhanceable by pds5^e6

(Fresán et al., 2020)

Pc³ has increased cell number | embryonic stage phenotype, enhanceable by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has visible | dominant phenotype, enhanceable by Adf1[+]/Adf1⁰¹³⁴⁹

(Orsi et al., 2014)

Pc³ has homeotic | dominant phenotype, enhanceable by Adf1[+]/Adf1⁰¹³⁴⁹

(Orsi et al., 2014)

Pc³ has homeotic | dominant | male phenotype, enhanceable by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

Pc³ has homeotic | dominant | male phenotype, enhanceable by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

Pc³ has visible phenotype, enhanceable by Hcf[+]/Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³ has visible | dominant phenotype, enhanceable by nej^UAS.Tag:V5/Scer\GAL4^hs.PB

(Tie et al., 2009)

Pc³ has homeotic phenotype, enhanceable by Kdm2^KG04325/Kdm2[+]

(Lagarou et al., 2008)

Pc³ has homeotic phenotype, enhanceable by Kdm2^EY01336/Kdm2[+]

(Lagarou et al., 2008)

Pc³ has homeotic phenotype, enhanceable by Kdm2[+]/Kdm2^DG12810

(Lagarou et al., 2008)

Pc³ has visible | dominant phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc³ has visible | dominant phenotype, enhanceable by hpo^MGH4/hpo[+]

(Parrish et al., 2007)

Pc³ has visible | dominant phenotype, enhanceable by esc²¹/esc[+]

(Parrish et al., 2007)

Pc³ has visible | recessive | homeotic phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has visible | recessive | homeotic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pc³ has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Pc³ has visible | dominant phenotype, enhanceable by psq[+]/psq^RF13

(Schwendemann and Lehmann, 2002)

Pc³ has visible | dominant phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Schwendemann and Lehmann, 2002)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm⁴

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm⁵

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^D1

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^D2

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^ET50

(Bornemann et al., 1998)

Pc³ has partially lethal | dominant phenotype, enhanceable by Scm^ET50

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^H1

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^K2

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^M36

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^M56

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^R5-13

(Bornemann et al., 1998)

Pc³ has partially lethal | dominant phenotype, enhanceable by Scm^R5-13

(Bornemann et al., 1998)

Pc³ has visible | dominant | homeotic phenotype, enhanceable by Scm^Suz302

(Bornemann et al., 1998)

Pc³ has partially lethal | dominant phenotype, enhanceable by Scm^Suz302

(Bornemann et al., 1998)

Pc³ has visible phenotype, enhanceable by corto⁴²⁰

(Kodjabachian et al., 1998)

Pc³/Pc[+], ph-p⁴¹⁰ has visible | dominant phenotype, enhanceable by E(Pc)17B[+]/E(Pc)17B^2.2.31

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has visible | dominant phenotype, enhanceable by E(Pc)17B[+]/E(Pc)17B^2.2.31

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has visible | dominant phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

Pc³/Pc[+], ph-p⁴¹⁰ has visible | dominant phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

NOT Enhanced by

Statement

Reference

Pc³ has homeotic phenotype, non-enhanceable by vtd^ex3

(Fresán et al., 2020)

Pc³ has homeotic phenotype, non-enhanceable by pds5^e6

(Fresán et al., 2020)

Pc³ has visible | embryonic stage phenotype, non-enhanceable by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has homeotic | embryonic stage phenotype, non-enhanceable by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has visible | dominant | homeotic phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Suppressed by

Statement

Reference

Pc³ has homeotic | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc³ has homeotic | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc³ has visible | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc³ has visible | dominant | male | adult stage phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc³ has visible | dominant | homeotic phenotype, suppressible by scf¹/scf[+]

(Ogasawara et al., 2007)

Pc³ has visible | dominant phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Pc³ has visible | dominant phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Pc³ has visible | dominant phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Pc³ has visible | dominant phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Pc³ has visible | dominant phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc³ has visible | dominant | homeotic phenotype, suppressible by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has visible | dominant | homeotic phenotype, suppressible by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³/Pc[+], ph-p⁴¹⁰ has visible | dominant phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has visible | dominant phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

Pc³ has visible | dominant | homeotic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Pc³ has visible | dominant | homeotic | heat sensitive phenotype, suppressible by M(3)80[+]/M(3)80¹

(Sinclair et al., 1984)

Pc³ has visible | dominant | homeotic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

NOT suppressed by

Statement

Reference

Pc³ has homeotic phenotype, non-suppressible by vtd^ex3

(Fresán et al., 2020)

Pc³ has homeotic phenotype, non-suppressible by pds5^e6

(Fresán et al., 2020)

Pc³ has visible | embryonic stage phenotype, non-suppressible by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has homeotic | embryonic stage phenotype, non-suppressible by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Enhancer of

Statement

Reference

Pc³ is an enhancer of visible | adult stage phenotype of Ubx^Cbx-1

(Hermann et al., 2022)

Pc³/Pc[+] is an enhancer of visible | adult stage phenotype of vg^CL2C/vg^nw

(Ahmad and Spens, 2019)

Pc³/Pc³ is an enhancer of increased cell number | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ is an enhancer of homeotic phenotype of Ubx^1:Cbx-1

(Dutta and Li, 2017)

Pc³ is an enhancer of visible phenotype of Ubx^1:Cbx-1

(Dutta and Li, 2017)

Pc³/Pc[+] is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc³/Pc[+] is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Pc³/Pc[+] is an enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Pc³/Pc[+] is an enhancer of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

NOT Enhancer of

Statement

Reference

Pc³/Pc³ is a non-enhancer of visible | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc³ is a non-enhancer of homeotic | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc[+] is a non-enhancer of decreased body size | adult stage phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Suppressor of

Statement

Reference

Pc³/Pc[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Pc³/Pc[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Pc³ is a suppressor of visible phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

Pc³ is a suppressor of abnormal eye color | male phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³ is a suppressor of abnormal eye color | female phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³/Pc[+] is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Pc³/Pc[+] is a suppressor of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Suppressor of

Statement

Reference

Pc³/Pc³ is a non-suppressor of visible | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc³ is a non-suppressor of homeotic | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc[+] is a non-suppressor of decreased body size | adult stage phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³/Pc[+] is a non-suppressor of increased cell death phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

Pc³ is a non-suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

Pc³, vg^CL2C has visible | adult stage phenotype

(Ahmad and Spens, 2019)

Pc³, wts^x1/wts[+] has abnormal neuroanatomy | dominant | somatic clone phenotype

(Parrish et al., 2007)

Pc³, sav[+]/sav³ has abnormal neuroanatomy | dominant | somatic clone phenotype

(Parrish et al., 2007)

Pc³, hpo^MGH4/hpo[+] has abnormal neuroanatomy | dominant | somatic clone phenotype

(Parrish et al., 2007)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has lethal | maternal effect | larval stage phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has lethal | maternal effect | larval stage phenotype

(Mollaaghababa et al., 2001)

Pc³, ss^a has visible phenotype

(Kuzin et al., 1997)

Pc³, crm⁷ has lethal | pharate adult stage phenotype

(Yamamoto et al., 1997)

Pc³, ph-p[+]/ph-p⁴¹⁰ has visible | dominant phenotype

(Fauvarque and Dura, 1993)

Pc³/Pc[+], ph-p⁴¹⁰ has visible | dominant phenotype

(Fauvarque and Dura, 1993)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc³ has mesothoracic leg phenotype, enhanceable by Adf1[+]/Adf1⁰¹³⁴⁹

(Orsi et al., 2014)

Pc³ has metathoracic leg phenotype, enhanceable by Adf1[+]/Adf1⁰¹³⁴⁹

(Orsi et al., 2014)

Pc³ has sex comb | ectopic phenotype, enhanceable by Adf1[+]/Adf1⁰¹³⁴⁹

(Orsi et al., 2014)

Pc³ has sex comb | ectopic | male phenotype, enhanceable by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

Pc³ has sex comb | ectopic | male phenotype, enhanceable by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

Pc³ has mesothoracic preepisternum phenotype, enhanceable by Hcf[+]/Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³ has sex comb | ectopic phenotype, enhanceable by nej^UAS.Tag:V5/Scer\GAL4^hs.PB

(Tie et al., 2009)

Pc³ has metathoracic leg phenotype, enhanceable by nej^UAS.Tag:V5/Scer\GAL4^hs.PB

(Tie et al., 2009)

Pc³ has sex comb | ectopic phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc³ has mesothoracic leg phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc³ has metathoracic leg phenotype, enhanceable by wts^x1/wts[+]

(Parrish et al., 2007)

Pc³ has sex comb | ectopic phenotype, enhanceable by hpo^MGH4/hpo[+]

(Parrish et al., 2007)

Pc³ has mesothoracic leg phenotype, enhanceable by hpo^MGH4/hpo[+]

(Parrish et al., 2007)

Pc³ has metathoracic leg phenotype, enhanceable by hpo^MGH4/hpo[+]

(Parrish et al., 2007)

Pc³ has sex comb | ectopic phenotype, enhanceable by esc²¹/esc[+]

(Parrish et al., 2007)

Pc³ has mesothoracic leg phenotype, enhanceable by esc²¹/esc[+]

(Parrish et al., 2007)

Pc³ has metathoracic leg phenotype, enhanceable by esc²¹/esc[+]

(Parrish et al., 2007)

Pc³ has sternopleural bristle phenotype, enhanceable by Caf1-180²⁷⁰/Caf1[+]

(Song et al., 2007)

Pc³ has adult external mesothorax phenotype, enhanceable by Caf1-180²⁷⁰/Caf1[+]

(Song et al., 2007)

Pc³ has adult external prothorax | ectopic phenotype, enhanceable by Caf1-180²⁷⁰/Caf1[+]

(Song et al., 2007)

Pc³ has haltere | ectopic phenotype, enhanceable by Caf1-180²⁷⁰/Caf1[+]

(Song et al., 2007)

Pc³ has wing phenotype, enhanceable by Caf1-180²⁷⁰/Caf1[+]

(Song et al., 2007)

Pc³ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^X

(Shanower et al., 2005)

Pc³ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^XXV

(Shanower et al., 2005)

Pc³ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp⁸

(Shanower et al., 2005)

Pc³ has haltere | ectopic | female phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has prothoracic leg | ectopic | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has sex comb | ectopic | male phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has wing | female phenotype, enhanceable by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has abdominal segment 4 | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has abdominal segment 5 | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has abdominal segment 5 | ectopic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has haltere | ectopic | female phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has haltere | ectopic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has prothoracic leg | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has sex comb | ectopic | male phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has sex comb | ectopic phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has wing | female phenotype, enhanceable by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has haltere | ectopic | female phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(van der Knaap et al., 2005)

Pc³ has wing | female phenotype, enhanceable by Usp7^KG06814/Usp7[+]

(van der Knaap et al., 2005)

Pc³ has haltere | ectopic | female phenotype, enhanceable by Usp7^kim1/Usp7[+]

(van der Knaap et al., 2005)

Pc³ has wing | female phenotype, enhanceable by Usp7^kim1/Usp7[+]

(van der Knaap et al., 2005)

Pc³ has abdominal segment 4 | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc³ has abdominal segment 5 | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc³ has mesothoracic leg | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc³ has prothoracic leg | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc³ has sex comb | ectopic | male phenotype, enhanceable by Usp7^kim1

(van der Knaap et al., 2005)

Pc³ has mesothoracic leg phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pc³ has sex comb | ectopic phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pc³ has mesothoracic leg phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pc³ has sex comb | ectopic phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pc³ has mesothoracic leg phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Pc³ has metathoracic leg phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Pc³ has sex comb | ectopic phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Pc³ has mesothoracic leg phenotype, enhanceable by psq[+]/psq^RF13

(Schwendemann and Lehmann, 2002)

Pc³ has metathoracic leg phenotype, enhanceable by psq[+]/psq^RF13

(Schwendemann and Lehmann, 2002)

Pc³ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq^RF13

(Schwendemann and Lehmann, 2002)

Pc³ has mesothoracic leg phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Schwendemann and Lehmann, 2002)

Pc³ has metathoracic leg phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Schwendemann and Lehmann, 2002)

Pc³ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Schwendemann and Lehmann, 2002)

Pc³ has sex comb | ectopic phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has antenna phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has leg | ectopic phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has mesothoracic leg phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has metathoracic leg phenotype, enhanceable by Trl[+]/Trl^R85

(Busturia et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 | male phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has sex comb phenotype, enhanceable by corto⁴²⁰

(Kodjabachian et al., 1998)

Pc³ has sex comb | ectopic & mesothoracic leg phenotype, enhanceable by Trl[+]/Trl^13C

(Strutt et al., 1997)

Pc³ has mesothoracic leg phenotype, enhanceable by Trl⁶²

(Strutt et al., 1997)

Pc³ has mesothoracic leg phenotype, enhanceable by Trl^13C

(Strutt et al., 1997)

Pc³ has sex comb | ectopic & mesothoracic leg phenotype, enhanceable by Trl[+]/Trl⁶²

(Strutt et al., 1997)

Pc³ has antenna phenotype, enhanceable by ph-p[+]/ph-p⁴¹⁰

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has antenna phenotype, enhanceable by E(Pc)17B[+]/E(Pc)17B^2.2.31

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has antenna phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

Pc³/Pc[+], ph-p⁴¹⁰ has antenna phenotype, enhanceable by E(Pc)17B[+]/E(Pc)17B^2.2.31

(Fauvarque and Dura, 1993)

Pc³/Pc[+], ph-p⁴¹⁰ has antenna phenotype, enhanceable by eff^mer1/eff[+]

(Fauvarque and Dura, 1993)

Pc³ has phenotype, enhanceable by Asx⁵

(Breen and Duncan, 1986)

Pc³ has phenotype, enhanceable by ph-d¹

(Dura et al., 1985)

Pc³ has phenotype, enhanceable by ph-d²

(Dura et al., 1985)

Pc³ has phenotype, enhanceable by ph-d⁴

(Dura et al., 1985)

Pc³ has embryonic segment phenotype, enhanceable by Df(2R)Pcl11B/Pcl¹

(Duncan, 1982)

Pc³ has mouth hook phenotype, enhanceable by Df(2R)Pcl11B/Pcl¹

(Duncan, 1982)

Pc³ has embryonic head phenotype, enhanceable by Df(2R)Pcl11B/Pcl¹

(Duncan, 1982)

NOT Enhanced by

Statement

Reference

Pc³ has ventral denticle belt | embryonic stage phenotype, non-enhanceable by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has abdominal tergite 4 | male phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, non-enhanceable by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 4 | male phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has abdominal tergite 6 phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 4 phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 5 | ectopic phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 6 phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has adult abdominal segment 7 | ectopic phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

Pc³ has antenna phenotype, non-enhanceable by trr¹

(Sedkov et al., 1999)

Pc³ has leg | ectopic phenotype, non-enhanceable by trr¹

(Sedkov et al., 1999)

Suppressed by

Statement

Reference

Pc³ has metathoracic leg | male phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc³ has wing phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc³ has prothoracic leg | ectopic | male phenotype, suppressible | partially by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

Pc³ has metathoracic leg | male phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc³ has mesothoracic leg | male phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc³ has prothoracic leg | ectopic | male phenotype, suppressible | partially by CtBP[+]/CtBP⁰³⁴⁶³

(Bi et al., 2022)

Pc³ has sex comb phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc³ has sex comb phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc³ has metathoracic leg phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc³ has mesothoracic leg phenotype, suppressible by rdx¹

(Strübbe et al., 2011)

Pc³ has metathoracic leg phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc³ has mesothoracic leg phenotype, suppressible by ebi^WKS-24

(Strübbe et al., 2011)

Pc³ has sex comb | ectopic phenotype, suppressible by polybromo^33.2/Bap170[+]/Bap170^G5986/polybromo[+]

(Chalkley et al., 2008)

Pc³ has sex comb | ectopic phenotype, suppressible by e(y)3⁴/Bap170[+]/Bap170^G5986

(Chalkley et al., 2008)

Pc³ has adult abdominal segment 4 | male phenotype, suppressible by scf¹/scf[+]

(Ogasawara et al., 2007)

Pc³ has adult abdominal segment 5 | ectopic | male phenotype, suppressible by scf¹/scf[+]

(Ogasawara et al., 2007)

Pc³ has abdominal tergite 4 | male phenotype, suppressible by scf¹/scf[+]

(Ogasawara et al., 2007)

Pc³ has ventral mesothoracic disc primordium phenotype, suppressible by Abd-B^iab8-D14

(Chen et al., 2005)

Pc³ has genital disc primordium | ectopic phenotype, suppressible by Abd-B^iab8-D14

(Chen et al., 2005)

Pc³ has sex comb | ectopic phenotype, suppressible by gpp[+]/gpp^1A

(Shanower et al., 2005)

Pc³ has sex comb | ectopic phenotype, suppressible by gpp[+]/gpp^94A

(Shanower et al., 2005)

Pc³ has abdominal segment 4 | male phenotype, suppressible by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has abdominal segment 4 phenotype, suppressible by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has abdominal segment 5 | ectopic | male phenotype, suppressible by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has mesothoracic leg phenotype, suppressible by bur¹/bur[+]

(van der Knaap et al., 2005)

Pc³ has mesothoracic leg phenotype, suppressible by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has wing phenotype, suppressible by bur[+]/bur^k07130

(van der Knaap et al., 2005)

Pc³ has mesothoracic leg phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Pc³ has mesothoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc³ has mesothoracic leg phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Pc³ has mesothoracic leg phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Pc³ has mesothoracic leg phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Pc³ has metathoracic leg phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Pc³ has metathoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc³ has metathoracic leg phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Pc³ has metathoracic leg phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Pc³ has metathoracic leg phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by Df(3L)vin2

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by tna^L6731

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by tna^S058302

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by tna^rI075

(Gutierrez et al., 2003)

Pc³ has sex comb | ectopic phenotype, suppressible by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³ has sex comb | ectopic phenotype, suppressible by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

Pc³, ss^a40aw has sex comb | ectopic phenotype, suppressible by trx^B22

(Kuzin et al., 1997)

Pc³/Pc[+], ph-p⁴¹⁰ has antenna phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

Pc³, ph-p[+]/ph-p⁴¹⁰ has antenna phenotype, suppressible by Su(Pc)35CD^T41.2/Su(Pc)35CD[+]

(Fauvarque and Dura, 1993)

Pc³ has mesothoracic leg & sex comb | ectopic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Pc³ has mesothoracic leg & sex comb | ectopic phenotype, suppressible by M(3)80¹

(Sinclair et al., 1984)

Pc³ has mesothoracic leg & sex comb | ectopic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

NOT suppressed by

Statement

Reference

Pc³ has ventral denticle belt | embryonic stage phenotype, non-suppressible by tara⁰³⁸⁸¹/tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³ has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Pc³ has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Pc³ has antenna phenotype, non-suppressible by trr¹

(Sedkov et al., 1999)

Pc³ has leg | ectopic phenotype, non-suppressible by trr¹

(Sedkov et al., 1999)

Enhancer of

Statement

Reference

Pc³ is an enhancer of wing phenotype of Ubx^Cbx-1

(Hermann et al., 2022)

Pc³/Pc[+] is an enhancer of wing phenotype of vg^CL2C/vg^nw

(Ahmad and Spens, 2019)

Pc³ is an enhancer of wing phenotype of Ubx^1:Cbx-1

(Dutta and Li, 2017)

Pc³/Pc[+] is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc³/Pc[+] is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Pc³/Pc[+] is an enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Pc³/Pc[+] is an enhancer of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

Pc³/Pc[+] is an enhancer of wing phenotype of RYBP^UAS.cBa, Scer\GAL4^sd-SG29.1

(Bejarano et al., 2005)

Pc³ is an enhancer of leg disc | somatic clone phenotype of wg^{αTub84B.Tag:HA}

(Lee et al., 2005)

Pc³ is an enhancer of wing disc | ectopic | somatic clone phenotype of wg^{αTub84B.Tag:HA}

(Lee et al., 2005)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-P6.1

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-28

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-2

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-P18.1

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-24

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-33

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-14

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-32

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-P14.1

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-19

(Mihaly et al., 1997)

Pc³ is an enhancer of phenotype of Abd-B^Fab7-3

(Mihaly et al., 1997)

Pc³/Pc[+] is an enhancer of antenna phenotype of ph-p⁴¹⁰

(Fauvarque and Dura, 1993)

NOT Enhancer of

Statement

Reference

Pc³/Pc³ is a non-enhancer of ventral denticle belt | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc[+] is a non-enhancer of humeral bristle phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³/Pc[+] is a non-enhancer of sex comb phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Suppressor of

Statement

Reference

Pc³/Pc[+] is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Pc³/Pc[+] is a suppressor of 1st posterior cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Pc³ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

Pc³/Pc[+] is a suppressor of wing vein | ectopic phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³/Pc[+] is a suppressor of haltere phenotype of RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-Gal4}, Ubx^lac1-GAL4

(Bejarano et al., 2005)

Pc³/Pc[+] is a suppressor of wing hair | ectopic phenotype of RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-Gal4}, Ubx^lac1-GAL4

(Bejarano et al., 2005)

Pc³/Pc[+] is a suppressor of trichome & haltere | ectopic phenotype of RYBP^UAS.cBa, Scer\GAL4^{Ubx-lac1-Gal4}, Ubx^lac1-GAL4

(Bejarano et al., 2005)

Pc³ is a suppressor of eye | ventral | female phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³ is a suppressor of eye | ventral | male phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³ is a suppressor of pigment cell | female phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³ is a suppressor of pigment cell | male phenotype of w^69C

(Kelley and Kuroda, 2003)

Pc³/Pc[+] is a suppressor of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Pc³/Pc[+] is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Suppressor of

Statement

Reference

Pc³/Pc³ is a non-suppressor of ventral denticle belt | embryonic stage phenotype of tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Pc³/Pc[+] is a non-suppressor of humeral bristle phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³/Pc[+] is a non-suppressor of sex comb phenotype of Hcf^HR1

(Rodriguez-Jato et al., 2011)

Pc³/Pc[+] is a non-suppressor of wing disc | third instar larval stage phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

Pc³/Pc[+] is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

Pc³, vg^CL2C has wing phenotype

(Ahmad and Spens, 2019)

Hcf^HR1, Pc³/Pc[+] has male genitalia phenotype

(Rodriguez-Jato et al., 2011)

Pc³, wts^x1/wts[+] has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

Pc³, sav[+]/sav³ has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

Pc³, hpo^MGH4/hpo[+] has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

Pc³, Usp7^kim1 has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^kim1 has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur¹/bur[+] has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur¹/bur[+] has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur¹/bur[+] has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur¹/bur[+] has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814/Usp7[+] has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814/Usp7[+] has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^kim1/Usp7[+] has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^kim1/Usp7[+] has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^KG06814 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, bur¹ has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur¹ has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur¹ has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur¹ has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^kim1 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, Usp7^kim1 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, Sirt1¹⁷/Sir2[+] has metathoracic leg phenotype

(Furuyama et al., 2004)

Pc³, Sir2[+]/Sirt1^2A-7-11 has metathoracic leg phenotype

(Furuyama et al., 2004)

Pc³, Sirt1¹⁷ has metathoracic leg phenotype

(Furuyama et al., 2004)

Pc³, Sirt1^2A-7-11 has metathoracic leg phenotype

(Furuyama et al., 2004)

Hsc70-4^54.1, Pc³ has wing phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has leg | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has wing phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has leg | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has abdominal tergite 1 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has antenna phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has abdominal tergite 7 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has abdominal tergite 1 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has haltere | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has adult abdominal segment 2 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Pc³ has adult abdominal segment 8 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has antenna phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has abdominal tergite 7 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has haltere | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has adult abdominal segment 2 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Pc³ has adult abdominal segment 8 | ectopic phenotype

(Mollaaghababa et al., 2001)

Pc³, ss^a has sex comb | ectopic phenotype

(Kuzin et al., 1997)

Pc³, ss^a40aw has sex comb | ectopic phenotype

(Kuzin et al., 1997)

Pc³, crm⁷ has metathoracic leg phenotype

(Yamamoto et al., 1997)

Pc³, crm⁷ has sex comb phenotype

(Yamamoto et al., 1997)

Pc³, crm⁷ has mesothoracic leg phenotype

(Yamamoto et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

vg^CL2C, Pc³ double heterozygotes display deformed wings.

Pc³ heterozygosity enhances the wing defects of vg^CL2C/vg^nw.

vg^R5/+, Pc³/+ and vg^R5/vg^nw, Pc³/+ adults do not show wing notching.

(Ahmad and Spens, 2019)

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of Pc³.

(Morimoto et al., 2016)

Adf1⁰¹³⁴⁹/+ enhances the ectopic sex comb phenotype seen in Pc³/+ males. The double heterozygotes have ectopic sex combs on the second leg (90% penetrance) and on the third leg (75% penetrance).

(Orsi et al., 2014)

The penetrance of the ectopic sex comb phenotype seen on the second and/or third legs of Pc³/+ flies (40%) is enhanced if they are also heterozygous for either upSET^e00365 (89%) or upSET^MB08950 (76%).

(Rincon-Arano et al., 2012)

The disorganised eye phenotype caused by expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^lz-gal4 is suppressed by Pc³.

(Anderson et al., 2011)

Hcf^HR1/+ enhances the penetrance of the T2 to T1 transformation (reduction of the sternopleural region) seen in Pc³/+ flies, from 3% to 40%.

The adult size and humeral bristle phenotypes of Hcf^HR1 mutants are not affected by Pc³/+. The reduced sex comb phenotype of Hcf^HR1 is not modified by Pc³/+. The ectopic vein phenotype of Hcf^HR1 mutants is suppressed by Pc³/+.

4% of Pc³/+ ; Hcf^HR1 males have defects in rotation of the genitalia.

(Rodriguez-Jato et al., 2011)

The increased apoptosis seen in Scer\GAL4^nub-AC-62 RYBP^Scer\UAS.cBa wing discs is unaffected in a Pc³/+ background.

(González and Busturia, 2009)

100% of Pc³/+ males that are also expressing nej^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^hs.PB at 29[o]C have sex comb bristles on the T3 legs.

(Tie et al., 2009)

The frequency of posterior-to-anterior leg transformations is reduced in transheterozygous males when Pc³ is combined with both Bap170^G5986/+ and polybromo^33.2/+. Hemizygous e(y)3⁴ males display an almost complete suppression of the Pc³ leg transformation phenotype.

(Chalkley et al., 2008)

The frequency of homeotic transformations is significantly higher in flies transheterozygous for Pc³ and Kdm2^KG04325, Kdm2^EY01336 or Kdm2^DG12810, compared to flies heterozygous for Pc³ alone.

(Lagarou et al., 2008)

The penetrance of the ectopic pigmentation phenotype seen in the A4 tergite of Pc³/+ males is reduced from 59.2% to 30.6% if they are also heterozygous for scf¹.

(Ogasawara et al., 2007)

Pc³/wts^x1,Pc³/sav³ and Pc³/hpo^MGH4 double heterozygous larvae show dendritic defects in ddaC neurons; there is a significant reduction in the number of dendritic branchpoints.

The ectopic sex comb phenotype seen on the second and third legs of Pc³/+ males is enhanced by wts^x1/+, esc²¹/+ and hpo^MGH4/+.

(Parrish et al., 2007)

One copy of Caf1-180²⁷⁰ enhances the loss-of-sternopleural-bristle and the wing-to-haltere transformation phenotypes of heterozygous Pc³.

(Song et al., 2007)

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc³ mutants.

(Ragab, 2006)

The ectopic wing hairs seen on the halteres of RYBP^Scer\UAS.cBa ; Ubx^lac1-GAL4 (Scer\GAL4^{Ubx-lac1-Gal4}) flies are suppressed by Pc³/+. In contrast, the reduced wing phenotype of RYBP^Scer\UAS.cBa; Scer\GAL4^sd-SG29.1 flies is enhanced by Pc³/+.

(Bejarano et al., 2005)

The ectopic genital disc precursor cells seen in Pc³ single mutant stage 15 embryos are absent in Pc³ Abd-B^iab8-D14 double mutant embryos and the leg disc precursor cells are present.

(Chen et al., 2005)

The addition of Pc³ increases the rate of leg to wing disc transdetermination to 17.7%.

(Lee et al., 2005)

Females transheterozygous for Usp7^KG06814 and Pc³ show antenna to leg transformations, which are not observed in Pc³ flies. Usp7^KG06814 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc³ flies. In combination with either hetero- (females) or hemizygous (males) Pc³ flies, Usp7^KG06814 significantly increases the penetrance of wing-to-haltere transformations. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. Transheterozygous Usp7^kim1/Pc³ flies exhibit partial antenna to leg transformations. Usp7^kim1 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc³ flies. For example, wing-to-haltere transformations occur only very rarely in heterozygous Pc³ flies. However, in combination with either hetero- or hemizygous Usp7^kim1, in respectively females or males, the penetrance of wing-to-haltere transformations is significantly increased. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. In males hemizygous for Usp7^kim1 and heterozygous for Pc³, the frequency of sex combs on the second leg (L2-L1) is strongly increased compared to flies harboring only a Pc³ mutation. Females transheterozygous for Usp7^kim1 and Pc³ exhibit antenna to leg (Ant-L) transformations, which are detected in Pc³ flies, but at a lower penetrance than in Usp7^KG06814/Pc³ flies. Flies transheterozygous for bur^k07130 and Pc³ exhibit very strong wing-to-haltere transformations. In addition, males transheterozygous for bur^k07130 and Pc³ also show partial transformation of the anterior abdominal segments A4 towards A5 and carry sex combs on the second legs.

(van der Knaap et al., 2005)

The frequency of ectopic sex combs seen in Pc³/+ males is increased by Sir2^2A-7-11; in Sir2^2A-7-11/+ ; Pc³/+ double heterozygous males, 98% of T2 legs and 61% of T3 legs have sex combs, while in Sir2^2A-7-11/Sir2^2A-7-11 ; Pc³/+ males, 99% of T2 legs and 78% of T3 legs have sex combs. The frequency of ectopic sex combs seen in Pc³/+ males is increased by Sir2¹⁷; in Sir2¹⁷/+ ; Pc³/+ double heterozygous males, 94% of T2 legs and 63% of T3 legs have sex combs.

(Furuyama et al., 2004)

Mutants heterozygous for lolal^k02512, lolal^k11212, or lolal^k07907, when also heterozygous for Pc³, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc. This phenotype is further enhanced in specific lolal heteroallelic viable combinations, such as lolal^k02512/lolal^311a, lolal^k11212/lolal^311a, and lolal^k07907/lolal^311a, when also heterozygous for Pc³.

(Faucheux et al., 2003)

Pc³ results in a weak derepression of w expression in the ventral part of the eye in both males and females carrying one copy of w^69C in a w^- background.

(Kelley and Kuroda, 2003)

Pc³/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

The penetrance of formation of ectopic sex combs on the mesothoracic and metathoracic legs of Pc³ heterozygous flies is significantly enhanced by heterozygosity for psq⁰¹¹⁵, psq^RF13 or Df(2R)Δ18.

(Schwendemann and Lehmann, 2002)

45% of Pc³/Trl^R85 double heterozygotes have extra sex combs (on the 2nd or 3rd leg) and 25% of Pc³/Trl^R85 double heterozygotes show transformation of antenna to leg.

(Busturia et al., 2001)

100% of Hsc70-4^54.1 Pc³ double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 100% of Hsc70-4^54.1 Pc³ double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 34 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-4^54.1 Pc³ double heterozygotes. Transformation of the first abdominal tergite towards A2 segment identity is seen in Hsc70-4^54.1 Pc³ double heterozygotes. The seventh tergite and sternite are almost completely removed, partially transformed into A8. Patches of wing tissue are transformed to haltere. 50% of flies show partial antenna-to-leg transformations. The progeny of Hsc70-4^54.1 Pc³ double heterozygous females often die as first instar larvae, even when fathers are wild type, but Hsc70-4^54.1 Pc³ double heterozygous males give viable offspring when mated to wild-type females.

(Mollaaghababa et al., 2001)

trr¹ neither enhances nor suppresses the Pc³/+ antenna transformation phenotype.

(Sedkov et al., 1999)

The homeotic phenotype of Pc³/+ adults is dominantly enhanced by Scm^M56, Scm^D1, Scm^Suz302, Scm^M36, Scm⁴, Scm^D2, Scm^H1, Scm^ET50, Scm^R5-13, Scm⁵ or Scm^K2. Partially lethal in double heterozygous combination with Scm^Suz302, Scm^ET50 or Scm^R5-13, with a higher percentage of males surviving than females.

(Bornemann et al., 1998)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is not suppressed by Pc³.

(Maixner et al., 1998)

ss^a flies carrying Pc³ exhibit 1-2 sex comb teeth on one of the legs of the second and third pair. ss^a40aw in the same genetic background exhibit sex combs on the tarsi of each leg. At lower temperatures, the number of teeth increases and segmentation of the leg is highly suppressed. Introduction of trx^B22 completely neutralizes the negative effect of Pc on the formation of tarsal structures.

(Kuzin et al., 1997)

The appearance of extra sex combs in Pc³/+ is enhanced if the flies are also heterozygous for either Trl⁶² or Trl^13C.

(Strutt et al., 1997)

Transheterozygotes of Pc³ with crm⁷ die as pharate adults, with second and third legs completely transformed towards the first. Ectopic sex comb teeth are found on the second tarsal segment of all legs.

(Yamamoto et al., 1997)

In combination with ph-p⁴¹⁰ (both heterozygous with wild type) an antenna to leg transformation is sometimes observed.

(Fauvarque and Dura, 1993)

The penetrance of the Pc³/+ extra sex comb phenotype is strongly reduced by M(3)80¹ at 29^oC but not at 22^oC. The penetrance of the phenotype is also reduced by M(2)56F^unspecified or Df(3L)M(3)LS4.

(Sinclair et al., 1984)

Pcl¹/Df(2R)Pcl11B; Pc³/Pc³ embryos show very extreme posteriorly directed segmental transformations, and have a stronger phenotype than +/+ ; Pc³/Pc³ embryos; posterior spiracle-like structures appear in most segments, the mouth hook apparatus is almost completely undeveloped and a region of the head (probably from the labial segment) develops an abdominal type denticle belt.

(Duncan, 1982)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of Pc³.

(Morimoto et al., 2016)

Complementation and Rescue Data

Rescued by

Pc³ is rescued by Pc^{Tag:CS(TEVp),Tag:StrepII}

(Strübbe et al., 2011)

Not rescued by

Pc³ is not rescued by Pc^EGFP

(Dietzel et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (9)

Bloomington

1730

In(3R)P(Pc³), Pc³/TM1

3399

st¹ in¹ kni^ri-1 Scr^W Pc³/TM3, Sb¹ Ser¹

3670

Dp(3;1)P115; Df(3R)P9, st¹ in¹ kni^ri-1 Pc³ Antp²¹ Ki¹ p^p/MKRS

Kyoto

106475

In(3R)P(Pc³), Pc³/TM1

107169

Df(3R)P10, st¹ in¹ kni^ri-1 Pc³ p^p abd-A^P10/TM6B, Tb⁺

107168

Dp(3;1)P115; Df(3R)P9, st¹ in¹ kni^ri-1 Pc³ Scr² p^p/TM3, Sb¹

107171

Dp(3;1)P115; Df(3R)P9, st¹ in¹ kni^ri-1 Pc³ Scr⁴ red¹/TM3, Sb¹

107167

Dp(3;1)P115; Df(3R)P9, st¹ in¹ kni^ri-1 Pc³ Scr⁴ Antp²⁵/TM3, Sb¹

107166

Dp(3;1)P115; Df(3R)P9, st¹ in¹ kni^ri-1 Pc³ Antp²¹ Ki¹ p^p/TM3, Sb¹

Notes on Origin

Discoverer

E.B. Lewis.

Lewis, 1965.

(Lewis, 1980)

Induced with: In(3R)P(Pc³).

(Lewis, 1980)

Comments

The anterior transformation of mesothoracic to prothoracic structures seen in Pc³ homozygotes depends on Scr⁺ activity.

(Sato and Denell, 1985)

Clonal analysis suggests that the dorsoventral compartment boundary of the wing may be affected in Pc mutants.

(Tiong and Russell, 1990)

In the metathorax Pc³ reduces Ubx abx mutant transformations but not bx ones, and can reduce pbx transformations if the mutant combination has a pbx cis regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Pc³ enhances the induction of ectopic expression of Ubx from a normal paired Ubx gene in trans by Ubx^Cbx-1, in flies carrying Ubx^Cbx-1 in cis with Ubx loss of function mutations.

(Castelli-Gair et al., 1990)

Ectopic abd-A is seen throughout the A-P axis by 9 hours. Ectopic Abd-B follows the same pattern but the anterior spread is delayed. Patchy Abd-B is seen in the epidermal cells of the head region.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.

(Muller, 1995)

Previously considered an antimorph, now known to be a protein null (R. Paro, personal communication).

(Soto et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Tariq et al., 2009)

Pc³

(He et al., 2023, Salzler et al., 2023, Bi et al., 2022, Cheng et al., 2022, Hermann et al., 2022, Fresán et al., 2020, Ahmad and Spens, 2019, Dutta and Li, 2017, Zouaz et al., 2017, Kang et al., 2015, Ríos-Barrera et al., 2015, Orsi et al., 2014, Ji et al., 2012, Park et al., 2012, Popkova et al., 2012, Rincon-Arano et al., 2012, Stern et al., 2012, Anderson et al., 2011, Enderle et al., 2011, Rodriguez-Jato et al., 2011, Strübbe et al., 2011, Saj et al., 2010, González and Busturia, 2009, Tie et al., 2009, Chalkley et al., 2008, González et al., 2008, Lagarou et al., 2008, Pérez-Lluch et al., 2008, Goodliffe et al., 2007, Ogasawara et al., 2007, Parrish et al., 2007, Song et al., 2007, de Navas et al., 2006, Le Bras and Van Doren, 2006, Bejarano et al., 2005, Canudas et al., 2005, Fitzgerald and Bender, 2001, Hirose et al., 2001, Choi et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (149)

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