FB2024_03 , released June 25, 2024
Allele: Dmel\Cyp6g1DDT-R
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General Information
Symbol
Dmel\Cyp6g1DDT-R
Species
D. melanogaster
Name
FlyBase ID
FBal0014805
Feature type
allele
Associated gene
Dmel\Cyp6g1
Associated Insertion(s)
accord{}Cyp6g1DDT-R
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Daborn et al., 2002, Lindsley and Zimm, 1992)
Progenitor genotype
Associated Insertion(s)
accord{}Cyp6g1DDT-R
Cytology
Description

Insertion of an accord element at the 5' end of the Cyp6g1 gene. This allele is associated with overtranscription of the Cyp6g1 gene.

(Daborn et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals show increased tolerance to methylmercury (assayed by increased eclosion of adult flies).

      (Rand et al., 2012)

      Mutant flies are more resistant to imidacloprid and to thiamethoxam compared to Canton-S flies. Mutant flies are more susceptible to diafenthiuron compared to Canton-S flies.

      (Shah et al., 2012)

      Both homozygous and heterozygous Cyp6g1DDT-R mutant flies lay an increased number of eggs compared to controls.

      (McCart and Ffrench-Constant, 2008)

      Cyp6g1DDT-R/+ flies whose Cyp6g1DDT-R allele is maternally inherited (RS) significantly outperform flies Cyp6g1DDT-R/+ whose Cyp6g1DDT-R allele is paternally inherited (SR) in counts of egg and larval viability at both 20 degrees C and 25 degrees C. However, this advantage disappears during the pupal stage and adult egg production. Both the larval and pupal development of the RS genotype is significantly faster than that of SR at 20 degrees C, however this advantage is obscured during faster development at 25 degrees C.

      (McCart et al., 2005)

      Cyp6g1DDT-R adults show increased resistance to DDT compared to Canton-S flies. Cyp6g1DDT-R larvae show increased resistance to imidacloprid and to malathion compared to Canton-S larvae.

      (Le Goff et al., 2003)

      Cyp6g1DDT-R animals show increased resistance to DDT and imidacloprid relative to Canton-S animals.

      (Daborn et al., 2001)

      Cyp6g1 is a major dominant gene responsible for the phenotype of a line selected for resistance to DDT. Median lethal dose of DDT for Cyp6g1 lines is about 4000 mug/cc of medium; that for sensitive lines is 50-100 mug/cc. Also resistant to BHC (benzene hexachloride) and organophosphorus insecticides such as parathion and malathion. Median lethal dose of parathion is 2 ppm for resistant line and 0.08 ppm for sensitive. Shows maternal effect in that progeny of Cyp6g1/+ female crossed to +/+ male are more resistant that those of reciprocal cross. Larva more resistant than adult. RK3.

      (Lindsley and Zimm, 1992)

      Sensitive to phenylthiocarbamide.

      (Davring and Sunner, 1971)

      Sensitive to phenylthiourea.

      (Ogita, 1958)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: a Hikone-R population.

      (Le Goff et al., 2003)
      Comments
      Comments

      Linkage between DDT resistance and the presence of the accord insertion in the 5' end of the Cyp6g1 gene is complete in naturally occurring strains, but the causal relation between the accord element and overtranscription of the Cyp6g1 gene seen in the resistant strains remains to be proven.

      (Daborn et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cyp6g1DDT-R
      Rst(2)DDT1
      Rst(2)DDTHikone-R
      (Daborn et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (15)