FlyBase Allele Report: Dmel\ry[2]

General Information

Symbol

Dmel\ry²

Species

D. melanogaster

Name

FlyBase ID

FBal0014906

Feature type

allele

Associated gene

Dmel\ry

Associated Insertion(s)

roo{}ry²

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Lindsley and Zimm, 1992)

Mutagen

spontaneous

(Covington et al., 1984)

Progenitor genotype

Associated Insertion(s)

roo{}ry²

Cytology

Description

roo insert at +3.2 kb.

(Lindsley and Zimm, 1992)

roo element insertion.

(Gray et al., 1991)

Insert stated as cause: undefined Insertion of DNA.

(Clark et al., 1986)

Insertion of a 9kb roo element into the structural portion of the gene.

(Covington et al., 1984)

Insertion of a roo element.

(Rushlow et al., 1984)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Hadorn and Schwinck, 1956)

partially lethal - majority die | partially | recessive | heat sensitive

(Hadorn and Schwinck, 1956)

Phenotype Manifest In

Malpighian tubule

(Hadorn and Schwinck, 1956)

pigment cell

(Hadorn and Schwinck, 1956)

Detailed Description

Statement

Reference

ry²/T(3;4)ry^ps1149 or ry²/In(3R)ry^ps11136 heterozygotes have ry^- eye colour when reared on low levels of the xanthine dehydrogenase inhibitor HPP and wild-type eye colour on standard medium. They are purine sensitive.

(Rushlow and Chovnick, 1984)

Eye colour: reddish brown. Ocellus colour: approximately wild-type. Malpighian tubule colour: slightly lighter than wild-type. Testis colour: wild-type. Malpighian tubules are shortened and malformed, containing yellow to orange-coloured globular inclusions in the lumen. Viable at 18^oC, subvital-semilethal in late pupae and adults at 25^oC. Nonautonomous with respect to the amount of red eye pigments and the appearance of isoxanthopterine in ry² transplants, and after implantation of ry⁺ fat bodies, Malpighian tubules and eye discs in ry² hosts. Wild-type eyes as transplants in ry² hosts form only the reduced amount of eye pigment characteristic of the mutant ry² host.

(Hadorn and Schwinck, 1956)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions