FB2024_04 , released June 25, 2024
Allele: Dmel\Sod1S
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General Information
Symbol
Dmel\Sod1S
Species
D. melanogaster
Name
Slow
FlyBase ID
FBal0015932
Feature type
allele
Associated gene
Dmel\Sod1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Phillips et al., 1995)
Progenitor genotype
Cytology
Description

Nucleotide replacement: SodS differs from SodF haplotype A at a single site, having an A instead of a C at site 1013.

(Hudson et al., 1994)

Asn96 -> Lys96 (Lee and Ayala, 1985)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_variant
3L:11,112,632..11,112,632 [-]
Reported nucleotide change:

C1013A|FBrf0073396

Reported nucleotide change:

A1013C|FBrf0073396

Comment:

nucleotide is an A instead of C in slow alleles.

(Hudson et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
S72589
AAD14963
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Relative frequencies of S and F vary greatly among natural populations. Slow forms of SOD have specific activity 2-3 times that of fast forms and they are more thermolabile (Lee, Misra and Ayala, 1981)

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      S
      (Nusbaum and Rose, 1994, Peng et al., 1991)
      Sod-Slow
      (Sezgin et al., 2004)
      Sod1S
      Sod1s
      (Kirby et al., 2008)
      SodS
      Name Synonyms
      Slow
      (Hudson et al., 1994)
      Secondary FlyBase IDs
        References (15)