FlyBase Allele Report: Dmel\speck[1]

General Information

Symbol

Dmel\speck¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015980

Feature type

allele

Associated gene

Dmel\speck

Associated Insertion(s)

412{}881

Carried in Construct

Also Known As

sp, sp¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

412{}881

Cytology

Description

7566bp 412 element is inserted in the 5'UTR in exon 1 of isoform RB of speck. The size, structure and location of the 412 insertion in speck¹ is identical to that found in speck² (the insertion in both mutants is represented by 412{}881 in the annotated reference genome).

(Spana et al., 2020)

Insertion of a 412 element within the transcription unit.

(Chakraborty et al., 2019)

Known mutation in sequenced strain.

(FlyBase Curators, 2002-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element

2R:24,147,123..24,154,643 [-]

(Spana et al., 2020, Chakraborty et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

visible | adult stage

(Spana et al., 2020)

visible | recessive

Phenotype Manifest In

anal pad | P-stage

(Spana et al., 2020)

wing hinge

(Spana et al., 2020)

Detailed Description

Statement

Reference

speck¹ adults exhibit ectopic pigmentation in the wing hinge.

speck¹ pupal cases exhibit excess pigmentation at the anal pad.

(Spana et al., 2020)

Displays a marked decrease in the amount of the A2 component of phenoloxidase.

(Warner et al., 1975)

In pupa, region of anal papilla is dark.

(Lindsley and Grell, 1968)

Body colour: dark; axils of wings have black specks.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

speck¹ has phenotype, suppressible by su(sable)²

(Warner et al., 1975)

speck¹ has phenotype, suppressible by svr^poi-dish

NOT suppressed by

Statement

Reference

speck¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

speck¹ is an enhancer of wing vein | adult stage phenotype of net¹

(Nagel et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The net¹ phenotype (ectopic veins, vein networking) can be enhanced by combination with CycG^HR7 but also by combination with mutant alleles of unrelated factors ru¹ or sp¹ demonstrating high susceptibility of the net¹ phenotype to perturbed genetic background.

(Nagel et al., 2016)

The levels of the A2 component of phenoloxidase are restored to normal in presence of su(s)².

(Warner et al., 1975)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type