FlyBase Allele Report: Dmel\Su(var)205[2]

Su(var)205² flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

(Haynes et al., 2006)

Su(var)205²/Df(2L)TE29Aa-11 and Su(var)205²/Su(var)205⁴ mutant third instar larvae have melanotic nodules found in the lymph glands. In Su(var)205²/Df(2L)TE29Aa-11 larvae, the melanotic nodules are surrounded by lamellocytes.

(Minakhina and Steward, 2006)

Su(var)205²/Su(var)205⁵ larvae show an extreme enlargement of the ring gland due to an increase in size of the prothoracic gland cells. The gastric caecae in these larvae are shorter and wider than normal and pair of the caecae are often fused.

(Spierer et al., 2005)

The larval imaginal discs of Su(var)205⁵/Su(var)205² mutants are similar to wild-type imaginal discs. Telomeres in Su(var)205² heterozygous strains are elongated with respect to the wild-type phenotype.

(Perrini et al., 2004)

Heterozygotes show no effect on crossing over between kni and p^p.

(Westphal and Reuter, 2002)

Su(var)205² suppresses the telomeric Position effect variegation (PEV) of P{hsp26-pt-T}118E-15, P{hsp26-pt-T}39C-56, P{hsp26-pt-T}39C-68, P{hsp26-pt-T}39C-72, P{hsp26-pt-T}HS-4, P{hsp26-pt-T}HS-6, Tp(4;3)X-10.

(Cryderman et al., 1999)

Su(var)205² suppresses Position Effect Variegation of w seen in P{hsp26-pt-T}39C-72, an insertion of P{hsp26-pt-T} into the 4th chromosome telomeric region. Su(var)205² suppresses Position Effect Variegation of Ecol\lacZ seen in P{70ZT(-194/+84)CCCA}2.7, an insertion of P{70ZT(-194/+84)CCCA} into the 4th chromosome telomeric region.

(Cryderman et al., 1999)

Suppresses transinactivation of bw caused by Tp(2;2)bw-DX7.

(Sass and Henikoff, 1999)

Suppresses PEV of eye color caused by insertions of P{hsp26-pt-T} that otherwise show PEV. The chromatin structure of P{hsp26-pt-T}118E-10 is more accessible to XbaI in a Su(var)205² mutant (accessibility 50%) than in Su(var)205⁺ (accessibility 9%).

(Cryderman et al., 1998)

Neuroblasts in the brain of Su(var)205²/Su(var)205⁵ larvae show normal metaphase configurations.

(Fanti et al., 1998)

Suppresses the position effect variegation at the w locus caused by In(1)w^m4 and suppresses the position effect variegation at the bw locus caused by In(2R)bw^VDe2 and Byron. Also suppresses the position effect variegation of w seen in the P{wA^R}41A insertion.

(Sass and Henikoff, 1998)

Homozygous embryos are found to be mostly devoid of intact nuclei. Any remaining nuclei have defects in chromosome segregation and abnormal morphology (chromatin bridges, chromosome lagging during anaphase and under- or over-condensed nuclei). Mitotic synchrony is lost in a high proportion of embryos and defective nuclei are seen beneath the normal plane of nuclei, they appear to be falling into the interior of the embryo.

(Kellum and Alberts, 1995)

Dominant suppressor of variegation.

(Platero et al., 1995)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(var)205²/Su(var)205⁴ has lethal phenotype, suppressible | partially by Hsap\CBX5^hs.PN

(Norwood et al., 2004)

Other

Statement

Reference

Su(var)205², XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1[+]/ADD1^NP1240, Su(var)205², XNP³/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

Su(var)205², Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype

(Li et al., 2011)

Su(var)205², Sxl^f1 has partially lethal - majority die | dominant | maternal effect phenotype

(Li et al., 2011)

P{P-Sal}Pak3^P-Sal, P{lacW}Dplac, Su(var)205² has suppressor of variegation phenotype

(Bushey and Locke, 2004)

Phenotype Manifest In

Other

Statement

Reference

Su(var)205², XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1[+]/ADD1^NP1240, Su(var)205², XNP³/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

A small percentage (2%) of Su(var)205²/+;XNP³/+ flies have melanotic masses; Su(var)205²/ADD1^NP1240 flies do not have melanotic masses; Su(var)205²/ADD1^NP1240;XNP³/+ flies have melanotic masses (14%).

(López-Falcón et al., 2014)

In progeny from Su(var)205² heterozygous females crossed to Sxl^fP7B0/Y males, female viability is reduced.

In progeny from Su(var)205² heterozygous females crossed to Sxl^f1/Y males, female viability is reduced.

(Li et al., 2011)

When P{P-Sal}89D is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w^- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Su(var)205².

(Bushey and Locke, 2004)

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

(McKee et al., 2000)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\Cbx5^hs.PN using daily heat shock in Su(var)205²/Su(var)205⁴ flies results in rescue of flies to adulthood (56% of the expected number of flies are rescued).

(Norwood et al., 2004)

Complementation and Rescue Data

Fails to complement

Su(var)205^P4

(Bushey and Locke, 2004)

Su(var)205¹⁴⁹

(Lu et al., 2000)

Rescued by

Su(var)205²/Su(var)205⁴ is rescued by Su(var)205^hs.lacI(DBD)

(Li et al., 2003)

Su(var)205² is rescued by Su(var)205^hs.PE

(Kellum and Alberts, 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101822

In(1)w^m4h ; Su(var)205² / SM1

Notes on Origin

Discoverer

Comments

The V26M mutation, which disrupts the gene silencing function of Su(var)205, destabilizes the His3-binding interface and abolishes methyl K-9 His3 tail binding.

(Jacobs et al., 2001)

The presence of Su(var)205² suppresses position effect variegation (PEV) of lines with insertions in centromeric regions or in the fourth chromosome. Insertions near the telomeres 2L, 2R or 3R show no suppression.

(Wallrath and Elgin, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

2-5⁰²

(McKee et al., 2000)

Su(var)205⁰²

(Wang et al., 2014, Sentmanat and Elgin, 2012, Minakhina and Steward, 2006, Ahmad and Henikoff, 2001, Sass and Henikoff, 1998, Pak et al., 1997, Wallrath and Elgin, 1995)

Su(var)205²

(López-Falcón et al., 2014, Li et al., 2011, Shaffer et al., 2006)

Su(var)25⁰²

(Sun et al., 2004)

Suvar(2)-5⁰²

(Perrini et al., 2004, Henikoff, 1996)

Suvar2-5⁰²

(Kellum and Alberts, 1995)

Name Synonyms

Secondary FlyBase IDs

References (43)

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