FlyBase Allele Report: Dmel\Ubx[bx-34e]

General Information

Symbol

Dmel\Ubx^bx-34e

Species

D. melanogaster

Name

FlyBase ID

FBal0017521

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

17.6{}Ubx^bx-34e

gypsy{}Ubx^bx-34e

Carried in Construct

Also Known As

bx^34e

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Peifer and Bender, 1986, Bender et al., 1983)

Progenitor genotype

Associated Insertion(s)

17.6{}Ubx^bx-34e

gypsy{}Ubx^bx-34e

Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)

Description

Insertion of a 17.6 element in the first intron at approximately 3R:16731980 (release 6 genome).

(Miller et al., 2016)

gypsy insertion in the cis-regulatory region.

(LaJeunesse and Shearn, 1995)

gypsy element insertion into the bx regulatory region. The direction of transcription of the gypsy element is in the opposite direction to Ubx transcription.

(Castelli-Gair and Garcia-Bellido, 1990)

Insertion of gypsy element, with its direction of transcription in the opposite orientation to the direction of Ubx transcription, into an intron of the Ubx transcription unit.

(Little et al., 1990)

Insertion of gypsy element.

(Mathog, 1990)

Insertion of a gypsy element. The direction of transcription of the gypsy element is opposite to the direction of transcription of Ubx.

(Micol et al., 1990)

gypsy insertion at -63.5kb in the same orientation as Ubx direction of transcription.

(Peifer and Bender, 1986)

Insertion of a 7.3kb gypsy element at map position -63.5kb.

(Bender et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

M23337

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Bondos et al., 2004)

visible | homeotic

(Ragab, 2006, Bender et al., 1983)

Phenotype Manifest In

adult mesothoracic segment | anterior | ectopic (with Ubx^6.28)

(Badenhorst et al., 2002)

adult metathoracic segment (with Ubx^6.28)

(Badenhorst et al., 2002)

haltere

(Tomoyasu et al., 2009, Ragab, 2006, Bondos et al., 2004, LaJeunesse and Shearn, 1995, Peifer and Bender, 1986, Bender et al., 1983, Bownes and Roberts, 1981, Lindsley and Grell, 1968)

haltere (with Ubx^6.28)

(Badenhorst et al., 2002)

katepimeron

(Peifer and Bender, 1986)

larval mesothoracic intersegmental nerve | adult stage | dorsal

(Teugels and Ghysen, 1985)

mesothoracic leg

(Lindsley and Grell, 1968)

metathoracic laterotergite

(Lewis, 1959)

metathoracic leg

(LaJeunesse and Shearn, 1995, Bender et al., 1983)

metathoracic leg | anterior

(Peifer and Bender, 1986)

metathoracic segment | dorsal

(Peifer and Bender, 1986)

sternopleural bristle

(Lindsley and Grell, 1968)

wing | ectopic

(Ragab, 2006)

wing | ectopic (with Ubx^6.28)

(Badenhorst et al., 2002)

Detailed Description

Statement

Reference

Ubx^bx-34e flies show a haltere to wing transformation.

(Ragab, 2006)

Ubx^61d, Ubx^pbx-1/Ubx^bx-34e mutants show a haltere-to-wing transformation.

(Ronshaugen et al., 2005)

Homozygotes have an enlarged haltere, with long, dark costal bristles. Heterozygotes have wild-type halteres.

(Bondos et al., 2004)

Ubx^6.28/Ubx^bx-34e mutant combinations cause a homeotic transformation of the third thoracic segment to the anterior second thoracic segment. The haltere (T3) is also transformed toward wing fate (t2), manifested by increases in size and the development of bristles.

(Badenhorst et al., 2002)

The Ubx^bx-34e phenotype is not suppressed in flies carrying su(Hw)^wt or su(Hw)^Δ656-705 in a su(Hw)⁷/su(Hw)^V background, partly suppressed in flies carrying su(Hw)^Δ706-736 or su(Hw)^Δ881-944 in a su(Hw)⁷/su(Hw)^V background, and strongly or completely suppressed in flies carrying su(Hw)^Δ673-943, su(Hw)^{Δ2-203.673-943}, su(Hw)^Δ738-780, su(Hw)^Δ2-203, su(Hw)^Δ853-880 or su(Hw)^Δ782-944 in a su(Hw)⁷/su(Hw)^V background.

(Kim et al., 1996)

Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

(Castelli-Gair and Garcia-Bellido, 1990)

Ubx^bx-34e/Ubx¹ flies do not have a T3a to T2a notal transformation. In the presence of a transvection suppressing chromosome rearrangement (TSR) the notum is strongly transformed.

(Mathog, 1990)

Ubx¹/Ubx^bx-34e flies have very little transformed dorsal metanotum.

(Babu et al., 1987)

Homozygotes and transheterozygotes of Ubx alleles demonstrate a significant enhancement of the bx phenotype when in combination with E(bx)². Haltere to winglike and metanotum to mesonotumlike transformations are enhanced.

(Bhosekar and Babu, 1987)

Different genetic combinations of Pc alleles and Ubx alleles suggest that the products of the bx region of Ubx are responsible for the "cbx" phenotype of the Pc mutations and in the absence of Pc the overexpression of bx gene products suppresses the pbx insufficiency phenotype in the posterior segments.

(Capdevila et al., 1986)

Haltere are transformed to wing and are 10-15% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 8-9 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern. Phenotype can be suppressed by su(Hw) mutations.

(Peifer and Bender, 1986)

Ubx^bx-34e shows the "ppx" transformation at 17^oC: ventral regions of T2p and T3p are affected.

(Casanova et al., 1985)

Flies usually have normal transversal fascicles in the adult CNS, although the anterior dorsal T3 fascicle is sometimes slightly malformed.

(Teugels and Ghysen, 1985)

Moderate transformation of anterior third thoracic segment to second thoracic segment.

(Bender et al., 1983)

Homozygotes show homeotic transformation of anterior haltere to anterior wing.

(Bownes and Roberts, 1981)

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubx^bx-34e.

(Capdevila and Garcia-Bellido, 1981)

Metathoracic outpushing is a uniform, narrow, hairy band. Balancers depressed, inflated, with elongated pointed tip and heavy line of costal bristles. Base of third leg shows sternopleural bristles like those of normal second leg. Metathoracic development of Ubx^bx-34e/Ubx^bx-34e > Ubx^bx-34e/Ubx^bx-W > Ubx^bx-34e/Ubx^bx-1. Ubx^bx-34e/Ubx¹ has round, flat, wing-like halteres; Ubx^bx-34e Ubx¹/+ + = Ubx¹/+ (Lewis). Complements Ubx^bxd-1. Reasonable viability and fecundity. Highly constant expression and easy separability. Expression increased slightly at 29^oC, decreased at 15^oC. RK2.

(Lindsley and Grell, 1968)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

NOT Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A^222.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-enhanceable by Nipped-A³²³

(Rollins et al., 1999)

NOT suppressed by

Statement

Reference

Ubx^bx-34e has visible | homeotic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A^222.3

(Rollins et al., 1999)

Ubx^bx-34e, su(Hw)^e2 has visible phenotype, non-suppressible by Nipped-A³²³

(Rollins et al., 1999)

Enhancer of

Statement

Reference

Ubx[+]/Ubx^bx-34e is an enhancer of visible | homeotic phenotype of Dsp1¹

(Decoville et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC6

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC7

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC23/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC39

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC41/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC59

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC71

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B^NC77/Nipped-B[+]

(Gause et al., 2008)

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype, enhanceable by Nipped-B[+]/Nipped-B^NC78

(Gause et al., 2008)

Ubx^6.28/Ubx^bx-34e has adult mesothoracic segment | anterior | ectopic phenotype, enhanceable by E(bx)^Nurf301-2

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has adult metathoracic segment phenotype, enhanceable by E(bx)^Nurf301-2

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has haltere phenotype, enhanceable by E(bx)^Nurf301-2

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has wing | ectopic phenotype, enhanceable by E(bx)^Nurf301-2

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has adult metathoracic segment phenotype, enhanceable by E(bx)^ry122

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has haltere phenotype, enhanceable by E(bx)^ry122

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has wing | ectopic phenotype, enhanceable by E(bx)^ry122

(Badenhorst et al., 2002)

Ubx^6.28/Ubx^bx-34e has adult mesothoracic segment | anterior | ectopic phenotype, enhanceable by E(bx)^ry122

(Badenhorst et al., 2002)

Ubx^bx-34e has haltere phenotype, enhanceable by z^1-35

(Rosen et al., 1998)

Ubx^bx-34e has adult metathoracic segment | dorsal phenotype, enhanceable by z^1-35

(Rosen et al., 1998)

Ubx^bx-34e has haltere phenotype, enhanceable by z^1-42

(Rosen et al., 1998)

Ubx^bx-34e has adult metathoracic segment | dorsal phenotype, enhanceable by z^1-42

(Rosen et al., 1998)

Ubx^bx-34e has phenotype, enhanceable by ash1²⁸

(LaJeunesse and Shearn, 1995)

Ubx^bx-34e has phenotype, enhanceable by ash2¹⁸

(LaJeunesse and Shearn, 1995)

Ubx^bx-34e has metathoracic laterotergite phenotype, enhanceable by z^ae(bx)

(Lewis, 1959)

Suppressed by

Statement

Reference

Ubx^bx-34e has phenotype, suppressible by su(Hw)^e2

(Morcillo et al., 1996, Dorsett, 1993)

Ubx^bx-34e has phenotype, suppressible by e(w^e)¹

(Rutledge et al., 1988)

Ubx^bx-34e has phenotype, suppressible by su(Hw)^unspecified

(Bender et al., 1983)

Ubx^bx-34e has phenotype, suppressible by su(Hw)²

(Lindsley and Grell, 1968)

NOT suppressed by

Statement

Reference

Ubx^bx-34e has haltere phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Ubx^bx-34e has wing | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Enhancer of

Statement

Reference

Ubx[+]/Ubx^bx-34e is an enhancer of haltere phenotype of Dsp1¹

(Decoville et al., 2001)

Ubx[+]/Ubx^bx-34e is an enhancer of wing | ectopic phenotype of Dsp1¹

(Decoville et al., 2001)

Other

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 has adult thorax phenotype

(Gause et al., 2008)

DIP1^c.UAS, Scer\GAL4^Bx-MS1096, Ubx^bx-34e has haltere phenotype

(Bondos et al., 2004)

Dp(1;Y)y⁺mal¹⁰⁶, Ubx^bx-34e has haltere phenotype

(Bondos et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Ubx^bx-34e, su(Hw)^e2 animals display a bithorax phenotype.

(Gause et al., 2008)

Df(2R)ED3921 fails to suppress the haltere to wing transformation of Ubx^bx-34e flies.

(Ragab, 2006)

Ubx^bx-34e/+ flies carrying Dp(1;Y)y⁺mal¹⁰⁶ have a punctate line of short, dark bristles on the capitellum and a denser cluster of bristles at the distal tip. Ubx^bx-34e/+ flies expressing DIP1^c.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 have long bristles along the entire surface of the haltere.

(Bondos et al., 2004)

The addition of E(bx)^Nurf301-2, E(bx)^ry122 or Df(3L)3643 to Ubx^bx-34e/Ubx^6.28 animals enhances the anterior transformation seen in both the third thoracic segment and the haltere.

(Badenhorst et al., 2002)

The frequency of transformation of halteres into wings seen in Dsp1¹/Y flies is enhanced by Ubx^bx-34e/+. The enhancement is dramatically reduced if the female parents are heterozygous rather than homozygous for Dsp1¹.

(Decoville et al., 2001)

Ubx^bx-34e Abd-B^Mc double heterozygous females show a significant increase in the level of monoene cuticular hydrocarbons and a significant decrease in the level of 7,11-diene cuticular hydrocarbons compared to wild-type females.

(Wicker-Thomas and Jallon, 2001)

The halteres of z^1-35/Y Ubx¹/Ubx^bx-34e or z^1-42/Y Ubx¹/Ubx^bx-34e males are larger than those of their z⁺ counterparts, and males have dorsal mesothoracic tissue on their metathorax. This effect is stronger for z^1-35 than for z^1-42.

(Rosen et al., 1998)

Double heterozygotes for ash1²⁸ at 27^oC exhibit haltere to wing transformation and third to second leg transformation. No transformation phenotype is seen at 20^oC. Double heterozygotes for ash2¹⁸ at 27^oC exhibit haltere to wing transformation.

(LaJeunesse and Shearn, 1995)

z^ae(bx) enhances the development of the dorsal metanotum in Ubx^bx-34e/Ubx¹ from a few hairs to a broad band of hairy tissue somewhat like that seen in Ubx^bx-34e homozygotes.

(Lewis, 1959)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Ubx^abx-1

(Lewis, 1980)

Comments

Images (0)

Mutant

Wild-type

Stocks (57)

Bloomington

3437

Ubx^bx-34e/TM1

3424

Ubx^bx-34e Ubx¹/TM1

3511

In(3R)Antp^B, Antp^B Ubx^bx-34e Ubx^bxd-121/TM1

1536

In(1)z^ae(bx), z^ae(bx); Sb^sbd-1 ss¹ Ubx^bx-34e/TM1

681

y² z^ae(bx)2 w^bf; Sb^sbd-2 ss¹ Ubx^bx-34e/TM1

Kyoto

105920

Ubx^bx-34e

107040

Ubx^bx-34e/TM1

108401

Dp(3;3)Cam35, Ubx^bx-34e/TM6B, Tb¹

101934

bw¹ ; c(3)G^OR-12-738 Ubx^bx-34e / TM3

102075

y¹ ; Dp(1;3)sc^J4 RpS17⁴ Sb^sbd-1 Ubx^bx-34e / TM1

107048

kni^ri-1 cu¹ kar¹ su(Hw)² jvl¹ Ubx^bx-34e/TM1

103319

Fdh^nNC1 / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹

More stocks available...

Notes on Origin

Discoverer

Schultz, 20 May 1934.

(Lindsley and Grell, 1968)

Schultz.

(Peifer and Bender, 1986)

Comments

The sensitivity of the metanotal transformation of the Ubx^unspecified/Ubx^bx-34e genotype to chromosomal rearrangements has been studied in the presence and absence of z^a.

(Babu and Bhat, 1981)

Partial revertant has been obtained that provides evidence that the gypsy element is responsible for the mutant phenotype.

(Bender et al., 1983)

Ubx mutants have been classified into "transvection groups", on the basis of transvection tests with Ubx^bx-34e, Ubx^pbx-2, and Ubx^Cbx-1 Ubx¹ mutants.

(Mathog, 1990)

Source of the gypsy element.

(Dorsett, 1990)

The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

(Castelli-Gair et al., 1992)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M23337

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ubx bx-34e

(Wicker-Thomas and Jallon, 2001)

Ubx^34e

(Decoville et al., 2001)

Ubx^bx-34e

(Monedero Cobeta et al., 2017, Miller et al., 2016, Tomoyasu et al., 2009)

bx^34e

(Gause et al., 2008, Lewis, 2003, Badenhorst et al., 2002, Duncan, 2002, Duncan and Montgomery, 2002, Decoville et al., 2001, Gerasimova et al., 2000, Rollins et al., 1999, Lewis, 1998, Rosen et al., 1998, Weatherbee et al., 1998, Casares et al., 1997, Milan et al., 1997, Kim et al., 1996, Martinez-Laborda et al., 1996, Morcillo et al., 1996, LaJeunesse and Shearn, 1995, Dorsett, 1993, Castelli-Gair et al., 1992, Harrison et al., 1992, Qian et al., 1991, Tartof and Henikoff, 1991, Castelli-Gair and Garcia-Bellido, 1990, Dorsett, 1990, Little et al., 1990, Mathog, 1990, Micol et al., 1990, Botas et al., 1988, Casanova et al., 1988, Parkhurst et al., 1988, Babu et al., 1987, Bhosekar and Babu, 1987, Weinzierl et al., 1987, Capdevila et al., 1986, Peifer and Bender, 1986, Casanova et al., 1985, Teugels and Ghysen, 1985, Bender et al., 1983, Kerridge and Morata, 1982, Babu and Bhat, 1981, Bownes and Roberts, 1981, Capdevila and Garcia-Bellido, 1981, Lewis, 1980, Lewis, 1959)

Name Synonyms

Secondary FlyBase IDs

References (69)

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