FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxpbx-2
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General Information
Symbol
Dmel\Ubxpbx-2
Species
D. melanogaster
Name
FlyBase ID
FBal0017569
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
Carried in Construct
Also Known As
pbx2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Lindsley and Zimm, 1992, Bender et al., 1983)
Progenitor genotype
Caused by aberration
Df(3R)Ubxpbx-2
Cytology

Polytene chromosomes normal.

(Lindsley and Zimm, 1992, Castelli-Gair and Garcia-Bellido, 1990)
Description

The deletion that causes this allele also deletes regions of the neighbouring bxd non-coding RNA gene.

(Petruk et al., 2006)

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

Deletion of DNA in the distal part of the bxd regulatory region.

(Castelli-Gair et al., 1992)

Deletion at Ubx at -30kb with respect to transcription start site.

(Muller and Bienz, 1991)

Deletion of DNA within the pbx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Deletion of Ubx sequences.

(Mathog, 1990)

Deletion of DNA.

(Micol et al., 1990)

Deletion of 15kb from map position -14 to +1kb.

(Bender et al., 1983)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A few double heterozygotes for ash128 at 27oC exhibit haltere to wing transformation. Double heterozygotes for ash218 at 20oC exhibit very mild haltere to wing transformation and at 27oC exhibit very mild third to second leg transformation.

      (LaJeunesse and Shearn, 1995)

      Homozygotes show complete T3p to T2p ("pbx") transformation. A1a is not affected.

      (Castelli-Gair et al., 1992)

      Increases the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      The Ubxpbx-2 is almost completely complemented when heterozygous with pseudopoint or point mutations of Ubx. In the presence of a transvection suppressing chromosome rearrangement (TSR) there is a strong transformation of T3p to T2p.

      (Mathog, 1990)

      Hemizygous flies show transformation of posterior haltere to wing and have extra dorsal postnotal tissue. These flies show variable slight reduction of the first abdominal tergite.

      (Bender et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lewis, 1980?.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      Ubx mutants have been classified into "transvection groups", on the basis of transvection tests with Ubxbx-34e, Ubxpbx-2, and UbxCbx-1 Ubx1 mutants. Ubxpbx-2 is transvection positive with Ubx point, pseudopoint and most breakpoint alleles. The Tp(3;3)bxd100 breakpoint marks the distal limit for transvection positive rearrangements.

      (Mathog, 1990)

      The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

      (Castelli-Gair et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (16)