FB2024_03 , released June 25, 2024
Allele: Dmel\vas5
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General Information
Symbol
Dmel\vas5
Species
D. melanogaster
Name
FlyBase ID
FBal0017849
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
Also Known As
vasO14
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: I271M.

(Lasko, 2000.2.1)

Nucleotide substitution of ATG for ATA, (amino acid replacement of I by M) in the 425 amino stretch that is highly similar among DEAD-box proteins.

(Liang et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,072,797..15,072,797 [+]
Nucleotide change:

T15072797G

Reported nucleotide change:

A?G

Amino acid change:

I271M | vas-PA; I271M | vas-PB; I271M | vas-PC

Reported amino acid change:

I271M

Comment:

Lasko, 2000.2.7, personal communication

(Liang et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      Oocytes from vas1 females express vas protein at normal levels throughout oogenesis.

      (Lasko and Ashburner, 1990)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Temperature sensitivity is restricted to the abdominal phenotype: at the restrictive temperature embryos lack abdomens.

      (Lehmann and Nusslein-Volhard, 1991)

      Progeny have no abdominal defects but still lack pole cells.

      (Lasko and Ashburner, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      vas1

      (Lehmann and Nusslein-Volhard, 1991)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      A weak vas allele.

      (Lasko and Ashburner, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (11)