FB2024_03 , released June 25, 2024
Allele: Dmel\vas6
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General Information
Symbol
Dmel\vas6
Species
D. melanogaster
Name
FlyBase ID
FBal0017850
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
Also Known As
vasQ6
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: V465M.

(Lasko, 2000.2.1)

Nucleotide substitution of ATG for GTG, (amino acid replacement of V by M) in the 425 amino stretch that is highly similar among DEAD-box proteins.

(Liang et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,073,377..15,073,377 [+]
Nucleotide change:

G15073377A

Reported nucleotide change:

G?A

Amino acid change:

V465M | vas-PA; V465M | vas-PB; V465M | vas-PC

Reported amino acid change:

V465M

Comment:

Lasko, 2000.2.7, personal communication

(Liang et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      46% of eggs laid by vas7/vas6 females have a micropyle at the posterior end of the egg. Occasionally, vas7/vas6 egg chambers containing two oocytes are seen. These are often adjacent to egg chambers that lack an oocyte. 100% of eggs laid by vas1/vas6 females appear wild-type.

      (Tomancak et al., 1998)

      Absence of posterior pole plasm, polar granules and pole cells.

      (Lehmann and Nusslein-Volhard, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      vas1

      (Lehmann and Nusslein-Volhard, 1991)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong allele of vas. Cytoplasmic transplantation of wild type plasm into the abdominal region restores normal abdominal development.

      (Lehmann and Nusslein-Volhard, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (8)