Polytene chromosomes normal.
Known mutation in sequenced strain: single base change in start codon (see FBrf0051634).
Deletion of the y promoter, not enhancer.
A to C tranversion in the ATG translation initiation codon.
A to C tranversion in the ATG translation initiation codon. The reference sequence strain, iso-1, carries the y1 mutation.
adult cuticle (with y1#8)
adult cuticle (with yeve-700gin)
adult cuticle (with yeve-tata-1)
adult cuticle (with yeve-tata)
adult cuticle (with yw-700gin)
adult cuticle (with yw-DPE26-1)
adult cuticle (with yw-DPE26)
adult cuticle (with yw-DPE29-1)
adult cuticle (with yw-DPE29)
wing (with yeve-700gin)
wing (with yeve-tata-1)
wing (with yhsp70-tata-1)
wing (with yw-DPE26-1)
wing (with yw-DPE29-1)
y1 individuals have a 'yellow' body color; the sex combs show reduced melanization and the sex comb teeth appeared thinner and smoother than in controls; the aedeagus show no melanization defects.
y1 males show severely reduced mating success when paired with wild-type females: copulation initiation is reduced, but there are no significant changes in courtship behavior (courtship time or wing extension bouts) or courtship song (pulse frequency, sine frequency or inter pulse interval), as compared to controls. This defect is not observed when y1 females are paired with wild-type males or when y1 males are paired with y1 females.
y1 males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y1 adults lack pigmentation throughout the body, the wings, bristles, aristae and tarsal claws. The sex combs of y1 males have a lighter colour than wild type.
Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1 (body), hemizygote: 1 (wing), 1 (body), y1/yeve-tata : 2 (wing), 2-3 (body), y1/yhsp70-tata : 4-5 (wing), 4+-5 (body), y1/yw-DPE26 : 4 (wing), 4 (body), y1/yw-DPE29 : 2 (wing), 1+-2 (body), y1/yeve-tata-1 : 1 (wing), 1 (body), y1/yhsp70-tata-1 : 1 (wing), 1 (body), y1/yw-DPE26-1 : 1 (wing), 1 (body), y1/yw-DPE29-1 : 1 (wing), 1 (body), y1/yP1\loxP.eve-700gin : 2+-3 (wing), 2+ (body), y1/yP1\loxP.hsp70-700gin : 5 (wing), 4+-5 (body), y1/yP1\loxP.w-700gin : 2+-3 (wing), 2+ (body).
Males have a reduced wing extension index (the percentage of each courtship ritual during which a male's wing is extended and vibrating) compared to wild type.
A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. I y1 mutants the black melanin is lost from the stripes leaving a brown pigment. The cuticle anterior to the stripe has a tan appearance relative to wild-type. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan.
Body colour: no pigmentation.
Body colour: yellow; hairs & bristles brown with yellow tips; wing veins, wing hairs, yellow. Larval mouth part colour: yellow-brown. Larval denticle belt colour: yellow-brown.
y[+]/y1 is an enhancer of chemical sensitive phenotype of Gk1RNAi.UAS, Scer\GAL4c564
y1 is a suppressor | partially of abnormal body color phenotype of Ask1ΔN.UAS.Tag:FLAG, Scer\GAL4pnr-MD237
e1, y1 has abnormal body color phenotype
y1 is a suppressor | partially of adult thorax phenotype of Ask1ΔN.UAS.Tag:FLAG, Scer\GAL4pnr-MD237
e1, y1 has adult cuticle phenotype
The glycerol hypersensitivity of flies expressing GykdsRNA.Scer\UAS under the control of Scer\GAL4c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for y1.
In a y1 hemizygous background, pigmentation in the thorax of Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 flies is brown rather than black, particularly in the scutellum.
A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment.
y1 is rescued by yUAS.cCa/Scer\GAL4dsx-GAL4
y1 is rescued by Scer\GAL4dsx.KI/yUAS.cCa
y1 is rescued by yUAS.cCa/Scer\GAL4c81
y1 is rescued by yUAS.cCa/Scer\GAL4Act5C.PI
y1 is partially rescued by yUAS.cCa/Scer\GAL80nSyb.PS/Scer\GAL4dsx-GAL4
y1 is partially rescued by yUAS.cCa/Scer\GAL4y.PG
y1 is not rescued by Scer\GAL4fru.P1.D/yUAS.cCa
The expression of yUAS.cCa under the control of Scer\GAL4y.PG suppresses the yellow body color but not the male mating defects of y1 mutants.
The expression of yUAS.cCa under the control of Scer\GAL4dsx-GAL4 alone or under the combined control of Scer\GAL4dsx-GAL4 and Scer\GAL80nSyb.PS fully and partially rescues, respectively, the male mating defects of y1 mutants.
The expression of yUAS.cCa under the control of Scer\GAL4dsx.KI rescues both the body color and male mating defects of y1 mutants.
Flies carrying yΔ1A-2.w-hs.Scer\SceI.RS or yΔ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS in a y1 background have dark pigmentation of all cuticle structures except the wing.
E.M. Wallace, Jan. 1911.
Marker mutation present in the strain used in the genome sequencing project.
y2 promoter causes trans-activation of enhancer.