FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-B05649
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General Information
Symbol
Dmel\Abd-B05649
Species
D. melanogaster
Name
FlyBase ID
FBal0019069
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
P{PZ}Abd-B05649
Carried in Construct
Also Known As
fs(3)5649, fs(3)05649
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Castrillon et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{PZ}Abd-B05649
Cytology
Description

P{PZ} insertion within the iab-7 domain, immediately adjacent to the minimal Fab-8 insulator.

(Zhou and Levine, 1999)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Almost all homozygous Abd-BFab8-305-Fab7 mutants (in a Abd-B05649 background) are wild type in appearance and are fertile. In rare cases flies patches of cells in A7 take on an A6 or A8 identity.

      Abd-BFab8-305-Fab7, Abd-B05649/Df(3R)R59 mutants display two distinct phenotypes; in some flies the A7 segments take on features characteristic of the A6 segment (a wider sternite with bristles oriented towards the lateral side) and in others they take on features normally seen in A8 (absence of trichomes). The phenotype appears identical regardless of the orientation of the insertion.

      (Iampietro et al., 2008)

      Heterozygous adult males show a normal segmentation pattern in the abdomen. Abd-B05649/Df(3R)Abd-BS10 males show abdominal transformations; the A7 tergite is fully developed in these animals, indicating a transformation towards an A5/A6 identity. In addition, the A5 tergite is partially transformed towards A4, as indicated by a partial loss of pigment in anterior regions and by the trichome pattern.

      (Zhou and Levine, 1999)

      Anal plate twisted in both males and females.

      (Castrillon et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      (Castrillon et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      Abd-B05649
      fs(3)05649
      (Bellen et al., 2004, Spradling et al., 1999)
      fs(3)5649
      (Barges et al., 2000, Zhou and Levine, 1999)
      iab-7p302
      (Zhou and Levine, 1999)
      ms(3)05649
      twig05649
      twig1
      (Castrillon et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)