FB2024_03 , released June 25, 2024
Allele: Dmel\Antp::Ubxhs.PM
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General Information
Symbol
Dmel\Antp::Ubxhs.PM
Species
D. melanogaster
Name
heat shock construct of Mann
FlyBase ID
FBal0030366
Feature type
allele
Associated gene
Antp::Ubx
Associated Insertion(s)
Carried in Construct
P{HS:Ubx-Antp}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rauskolb et al., 1993, Mann and Hogness, 1990)
Progenitor genotype
Carried in construct
P{HS:Ubx-Antp}
Cytology
Description

An Hsp70 promoter drives expression of a chimeric protein; N terminus is derived from Ubx and the C terminus from Antp.

(Mann and Hogness, 1990)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Antp::Ubx
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In either a wild type or an exd mutant background, heat shock of the embryo causes failure of head involution and a T1 to T2 transformation.

      (Rauskolb et al., 1993)

      Ectopic expression in embryos causes a phenotype very similar to that of Antphs.PHTA. Phenotype differs in that formation of the thoracic segment specific sensory organs (Keilin's organ and ventral pits) is suppressed. Parasegments have a mixed identity, denticle belt phenotype has an Antp-like parasegment 4 identity but the suppression of thoracic segment specific sensory organs has a Ubx-like parasegment 6 identity. Heat shock of the construct in Antp25 embryos displays 100% transformation of thoracic and head parasegments.

      (Mann and Hogness, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Antp::Ubxhs.PM
      Name Synonyms
      heat shock construct of Mann
      (Mann and Hogness, 1990)
      Secondary FlyBase IDs
        References (2)