FB2024_03 , released June 25, 2024
Allele: Dmel\dppH91
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General Information
Symbol
Dmel\dppH91
Species
D. melanogaster
Name
FlyBase ID
FBal0031057
Feature type
allele
Associated gene
Dmel\dpp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wharton et al., 1996, Wharton et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: P545L.

(Wharton et al., 1996)

Mutation falls in the C-terminal ligand region of the dpp protein.

(Wharton et al., 1996)

Nucleotide substitution: C2851T.

(Wharton et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,458,457..2,458,457 [+]
Nucleotide change:

C2458457T

Reported nucleotide change:

C2851T

Amino acid change:

P555L | dpp-PA; P555L | dpp-PB; P555L | dpp-PC; P555L | dpp-PE

Reported amino acid change:

P545L

Comment:

The @dpp[H91] mutation was reported as P545L but the reported nucleotide location and the position of the mutation in the context of the dpp amino acid sequence indicate that it was mapped to P555L.

(Wharton et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dorsal epidermis is entirely absent and the ventral denticle belts for circumferential rings over the entire cuticle.

      (Wharton et al., 1996)

      Dominant lethality greater than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

      (Wharton et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Blackman.

      (Wharton et al., 1993)
      Comments
      Comments

      Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dppe87 < dppe90 < dpphr56 < dpphr4 < dpphr92 < dpphr27 < dpphr93 < dppH94 < dppH95 < dppH96 = dppH91 = dppH46.

      (Wharton et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dppH91
      Name Synonyms
      Secondary FlyBase IDs
        References (2)