FB2024_03 , released June 25, 2024
Allele: Dmel\pnrD4
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General Information
Symbol
Dmel\pnrD4
Species
D. melanogaster
Name
FlyBase ID
FBal0032461
Feature type
allele
Associated gene
Dmel\pnr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

gain of function allele

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Heitzler et al., 1996, Ramain et al., 1993)

gain of function allele

(Heitzler et al., 1996)
Mutagen
ethyl methanesulfonate
(Heitzler et al., 1996, Ramain et al., 1993)
Progenitor genotype
Cytology
Description

Point mutation in the first zinc finger domain.

(Heitzler et al., 1996)

Nucleotide substitution: G996A. This causes a glu (conserved in GATA protein family) to lys substitution within a 23 amino acid stretch in the region of the N-terminal zinc finger.

(Ramain et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,039,061..16,039,061 [+]
Nucleotide change:

G16039061A

Reported nucleotide change:

G996A

Amino acid change:

E168K | pnr-PA; E116K | pnr-PB; E168K | pnr-PC; E116K | pnr-PD

Reported amino acid change:

E?K

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. (Figure 3 and Table 1)

(Ramain et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes exhibit a dorsal hole. Heterozygotes exhibit a strong thoracic cleft defects and lack postverticals, inner verticals and some anterior orbitals, extra dorsocentral and scutellar bristles. Heterozygotes with pnrVX5 exhibit variegating position effect.

      (Heitzler et al., 1996)

      Heterozygotes display extra dorsocentral bristles. Dominant phenotype enhanced in viable transallelic combinations with pnrV1.

      (Ramain et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class A allele. Allelic series for dominant phenotype, going from greatest to least effect pnrD4 > pnrD1 > pnrD2 = pnrD3.

      (Ramain et al., 1993)

      Class 4 pnr allele: dominant allele causing a gain of bristles. Associated with Akt12.

      (Heitzler et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pnrD4
      (Fromental-Ramain et al., 2010)
      pnrD
      (Tomoyasu et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)