FB2024_03 , released June 25, 2024
Allele: Dmel\pll25
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General Information
Symbol
Dmel\pll25
Species
D. melanogaster
Name
FlyBase ID
FBal0035426
Feature type
allele
Associated gene
Dmel\pll
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q93term.

    (Towb et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:27,252,681..27,252,681 [-]
    Nucleotide change:

    C27252681T

    Amino acid change:

    Q93term | pll-PA; Q93term | pll-PB

    Reported amino acid change:

    Q93term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Towb et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        pll7/pll25 larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.

        (Minidorff et al., 2007)

        Homozygous and pll7/pll25 larvae have significantly higher levels of muscle defects than wild-type larvae.

        (Halfon and Keshishian, 1998)

        Completely dorsalised embryos. Heterozygotes produced some dorsalised phenotypes at 29oC when also heterozygous for Df(3R)XM3.

        (Hecht and Anderson, 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        tubE50K does not rescue the defects of embryos derived from pll25/Df(3R)IR16 embryos when injected into these embryos as RNA. tubE50K and pllR35E show slight rescue of the defects of embryos derived from pll25/Df(3R)IR16 embryos when injected together into these embryos as RNA, although they do not show any rescue when injected alone.

        (Xiao et al., 1999)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Strong pll allele.

        (Hecht and Anderson, 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pll25
        (Wang et al., 2017, Minidorff et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)