FB2024_03 , released June 25, 2024
Allele: Dmel\slp1Δ46G
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General Information
Symbol
Dmel\slp1Δ46G
Species
D. melanogaster
Name
FlyBase ID
FBal0035633
Feature type
allele
Associated gene
Dmel\slp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Cadigan et al., 1994, Grossniklaus et al., 1992)
Mutagen
Delta2-3 transposase
(Cadigan et al., 1994, Grossniklaus et al., 1992)
Progenitor genotype
Cytology
Description

Deletion of sequences between the insertion point of P{lArB}A208.1M2 and P{lArB}slp1A509.

(Grossniklaus et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:3,825,564..3,825,564 [+]
Comment:

one breakpoint of slp1Delta6G; a deletion of sequences between two P insertions.

(Grossniklaus et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes display partial fusion of segments in a pair rule fashion, naked cuticle is still present. Heterozygotes with slp13 are lethal and transheterozygotes with Df(2L)slp-Δ34B and Df(2L)ed1 display an intermediate cuticular phenotype. One copy of the construct P{HS-slp1} can rescue transheterozygotes with Df(2L)slp-Δ34B to adulthood.

      (Cadigan et al., 1994)

      Head involution fails. Whereas the mandibular lobe does not form at all, the labial lobe deteriorates during germ band retraction, along with the mesothoracic and odd-numbered abdominal segments.

      (Grossniklaus et al., 1994)

      Moderate slp1 cuticle phenotype affecting the odd numbered segments. Head lobes fail to involute.

      (Grossniklaus et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Comments
      Comments

      Phenotypic analysis of different slp1 and slp2 alleles establishes an allelic series: slp11 < slp1Δ41E < slp1A509 < slp13 < slp1Δ46G < slp2Δ66C < slp1Δ34B = slp2Δ34B.

      (Grossniklaus et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slp1Δ46G
      slpΔ46G
      (Harbecke and Lengyel, 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)