FlyBase Allele Report: Dmel\klar[marb-BP]

General Information

Symbol

Dmel\klar^marb-BP

Species

D. melanogaster

Name

FlyBase ID

FBal0039623

Feature type

allele

Associated gene

Dmel\klar

Associated Insertion(s)

Carried in Construct

Also Known As

klar^mBP

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Mosley-Bishop et al., 1999, Fischer-Vize and Mosley, 1994)

Mutagen

Delta2-3 transposase

(Fischer-Vize and Mosley, 1994)

Progenitor genotype

Caused by aberration

T(2;3)marb^BP

Cytology

Description

The lesion is between exons 4 and 5.

(Guo et al., 2005)

A lesion exists in the second intron of the klar open reading frame.

(Mosley-Bishop et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Mosley-Bishop et al., 1999)

visible

(Mosley-Bishop et al., 1999)

visible | recessive

(Fischer-Vize and Mosley, 1994)

Phenotype Manifest In

eye

(Mosley-Bishop et al., 1999, Fischer-Vize and Mosley, 1994)

eye (with Df(3L)emc-E12)

(Fischer et al., 2004)

lipid droplet

(Guo et al., 2005, Welte et al., 1998)

ommatidium

(Mosley-Bishop et al., 1999)

photoreceptor cell & nucleus (with Df(3L)emc-E12)

(Fischer et al., 2004)

presumptive embryonic salivary gland

(Myat and Andrew, 2002)

rhabdomere

(Mosley-Bishop et al., 1999)

rhabdomere (with Df(3L)emc-E12)

(Fischer et al., 2004)

Detailed Description

Statement

Reference

klar^marb-BP embryos show aberrant lipid droplet transport.

(Guo et al., 2005)

klar^marb-BP/Df(3L)emc-E12 animals have eye defects. The photoreceptor cells are present, largely in their normal positions, but the rhabdomeres are malformed. In contrast to wild type, where the photoreceptor cell nuclei are apical, in klar^marb-BP/Df(3L)emc-E12 eye discs, the photoreceptor cell nuclei are either basal or randomly distributed throughout the apical/basal plane.

(Fischer et al., 2004)

The size of the salivary gland lumen is reduced in homozygous embryos.

(Myat and Andrew, 2002)

In klar^marb-BP/Df(3L)emc-E12 flies, the surface of the eye is rough. In the retina, within ommatidia the wild-type number of rhabdomeres are present, but are malformed.

(Mosley-Bishop et al., 1999)

Homozygotes show defects in lipid droplet transport.

(Welte et al., 1998)

Rough eye phenotype.

(Fischer-Vize and Mosley, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

klar¹

(Welte et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

klar^MBP

(Kracklauer et al., 2007, Myat and Andrew, 2002)

klar^mBP

(Kim et al., 2013, Kracklauer et al., 2007, Guo et al., 2005, Fischer et al., 2004, Patterson et al., 2004, Mosley-Bishop et al., 1999)

klar^marb-BP

kls^marb-BP

marb^BP3

(Welte et al., 1998)

marb^BP

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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