FB2024_03 , released June 25, 2024
Allele: Dmel\tllhs.PS
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General Information
Symbol
Dmel\tllhs.PS
Species
D. melanogaster
Name
heat shock construct of Steingrimsson
FlyBase ID
FBal0046592
Feature type
allele
Associated gene
Dmel\tll
Associated Insertion(s)
Carried in Construct
P{HS-tll}
Also Known As
hs-tll
Key Links
Transgenic product class
wild_type
(Steingrimsson et al., 1991)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Steingrimsson et al., 1991)
Mutagen
in vitro construct
(Strecker et al., 1992, Steingrimsson et al., 1991)
Progenitor genotype
Carried in construct
P{HS-tll}
Cytology
Description

Contains tll under the control of an Hsp70 promoter.

(Steingrimsson et al., 1991)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
tll
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tllhs.PS in embryos results in a weak dorsal open phenotype. The pattern of ventral denticles appears grossly normal.

      (Gritzan et al., 2002)

      Embryos ectopically expressing tllhs.PS lack the Bolwig's organ, while the optic lobe is present. The optic lobes are located more dorsally than normal and are fused in the dorsal midline.

      (Daniel et al., 1999)

      lin2, ems1, zen4, fogS4, pebhnt-E8 and sogS6 can restore central, segmental development in tllhs.PS embryos.

      (Strecker et al., 1992)

      Embryos show increasing repression of segmentation with increasing duration of early heat shock (at 1.5 to 2.5 hours). This repression spreads from a central position at approximately 40% egg length. Embryos heat shocked later (at 2.5 to 3 hours) generally form cuticles with a continuous field of nonpolar denticles. Filzkorper are formed and segmentation is repressed in heat shocked embryos carrying tllhs.PS and derived from tor1, trk1 females.

      (Steingrimsson et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutations in genes known to act in the terminal signalling pathway in the embryo have been tested for their ability to restore central, segmental development in tllhs.PS embryos, to determine which genes act downstream or independently of tll.

      (Strecker et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tllhs.PS
      Name Synonyms
      heat shock construct of Steingrimsson
      (Steingrimsson et al., 1991)
      Secondary FlyBase IDs
        References (7)