FlyBase Allele Report: Dmel\kay[UAS.cEa]

General Information

Symbol

Dmel\kay^UAS.cEa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Eresh

FlyBase ID

FBal0060698

Feature type

allele

Associated gene

Dmel\kay

Associated Insertion(s)

Carried in Construct

P{UAS-Fra}

Also Known As

UAS-fos, UAS-Dfos, UAS-Fos^WT

Key Links

Transgenic product class

wild_type

(Eresh et al., 1997)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Eresh et al., 1997)

Mutagen

in vitro construct

(Eresh et al., 1997)

Progenitor genotype

Carried in construct

P{UAS-Fra}

Cytology

Description

UASt regulatory sequences drive expression of full-length kay.

(Eresh et al., 1997)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

kay

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology, with Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

partially lethal - majority live, with Scer\GAL4^αTub84B.PL

(Gritzan et al., 2002)

Phenotype Manifest In

adult thorax, with Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Detailed Description

Statement

Reference

Larval eye-antennal disc clones expressing kay^Scer\UAS.cEa under the control of Scer\GAL4^Act.PU do not exhibit size defects or differences in number or morphology of clones, as compared to controls.

(Külshammer et al., 2015)

Expression of kay^Scer\UAS.cEa in the RP2 motor neurons (using the Scer\GAL4^eve.RRK driver to drive expression of Scer\FLP1^Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4^Act.PU) has no significant effect on RP2 dendrite volume.

(Hartwig et al., 2008)

Expression of kay^Scer\UAS.cEa under the control of Scer\GAL4^pnr-MD237 results in a weak cleft thorax phenotype, while expression under either Scer\GAL4^ey.PH or Scer\GAL4^how-24B does not result in a visible phenotype.

(Cerrato et al., 2006)

Flies expressing kay^Scer\UAS.cEa under the control of Scer\GAL4^αTub84B.PL are semi-viable at 18 and 25^oC.

(Gritzan et al., 2002)

Expression of kay^Scer\UAS.cEa under the control of Scer\GAL4^elav-C155 does not affect EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered.

(Sanyal et al., 2002)

Flies expressing kay^Scer\UAS.cEa under the control of Scer\GAL4^tim.Scer\UAS have wild-type locomotor activity rhythms.

(Blau and Young, 1999)

Causes no effect on copper cell development, when expression is driven by Scer\GAL4^48Y.

(Riese et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neuroanatomy phenotype, enhanceable by Jra^UAS.cEa, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Suppressed by

Statement

Reference

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neurophysiology phenotype, suppressible by sgg^EY02862, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neurophysiology phenotype, suppressible | partially by dnc^UAS.cCa, Scer\GAL4^elav-C155

(Sanyal et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neurophysiology phenotype, suppressible | partially by CrebB^b.hs

(Sanyal et al., 2002)

Enhancer of

Statement

Reference

kay^UAS.cEa, Scer\GAL4^elav-C155 is an enhancer of abnormal neuroanatomy phenotype of Jra^UAS.cEa, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Suppressor of

Statement

Reference

kay^UAS.cEa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Atf3^UAS.cSa, Scer\GAL4^GMR.PF

(Sekyrova et al., 2010)

Scer\GAL4^elav-C155/kay^UAS.cEa is a suppressor of abnormal neurophysiology phenotype of Scer\GAL4^elav-C155, sgg^A81T.UAS

(Franciscovich et al., 2008)

Jra^UAS.cEa/kay^UAS.cEa, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, sgg^EY02862

(Franciscovich et al., 2008)

kay^UAS.cEa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hs.2sev/kay^UAS.cEa is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pnt^P2.UAS

(Weber et al., 2008)

Scer\GAL4^hs.2sev/kay^UAS.cEa is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Ciapponi et al., 2001)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has hyperplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has abnormal neuroanatomy phenotype

(Vonhoff et al., 2013, Hartwig et al., 2008)

Jra^UAS.cEa, Scer\GAL4^103.3, kay^UAS.cEa has abnormal neuroanatomy phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, kay^UAS.cEa has abnormal neuroanatomy phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^Toll-6-D42, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has abnormal neuroanatomy phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK, kay^UAS.cEa has abnormal neuroanatomy | somatic clone phenotype

(Hartwig et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav.PH, kay^UAS.cEa has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype

(Haussmann et al., 2008)

Scer\GAL4^αTub84B.PL, eg^18B, kay^UAS.cEa has lethal phenotype

(Gritzan et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neuroanatomy phenotype

(Sanyal et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has abnormal neurophysiology phenotype

(Sanyal et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, kay^UAS.cEa has adult thorax phenotype, enhanceable by Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^ey.3.5.Exel, kay^Fbz.UAS, kay^UAS.cEa has eye phenotype, suppressible by Jra^UAS.cEa, Scer\GAL4^ey.3.5.Exel

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, suppressible by cnk^EY06675, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, suppressible by Fkbp14^EY02405, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, suppressible by Pde8^EY10143, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, suppressible by sgg^EY02862, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, suppressible by Sdc^EY04602, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has neuromuscular junction | larval stage phenotype, suppressible | partially by CrebB^b.hs

(Sanyal et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has neuromuscular junction | larval stage phenotype, suppressible | partially by dnc^UAS.cCa, Scer\GAL4^elav-C155

(Sanyal et al., 2002)

NOT suppressed by

Statement

Reference

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype, non-suppressible by Sema2a^EY08184, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has bouton | increased number phenotype, non-suppressible by CrebB^b.hs

(Sanyal et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has bouton | increased number phenotype, non-suppressible by dnc^UAS.cCa, Scer\GAL4^elav-C155

(Sanyal et al., 2002)

Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/kay^UAS.cEa is an enhancer of synapse phenotype of Jra^UAS.cEa

(Franciscovich et al., 2008)

kay^UAS.cEa, Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Scer\GAL4^32B/kay^UAS.cEa is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^32B, rl^Sem.C.UAS

(Ciapponi et al., 2001)

Suppressor of

Statement

Reference

kay^UAS.cEa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Atf3^UAS.cSa, Scer\GAL4^GMR.PF

(Sekyrova et al., 2010)

Jra^UAS.cEa/kay^UAS.cEa, Scer\GAL4^elav-C155 is a suppressor of synapse phenotype of Scer\GAL4^elav-C155, sgg^EY02862

(Franciscovich et al., 2008)

kay^UAS.cEa, Scer\GAL4^ey.3.5.Exel is a suppressor of eye phenotype of Jra^UAS.cEa, Scer\GAL4^ey.3.5.Exel, kay^Fbz.UAS

(Franciscovich et al., 2008)

kay^UAS.cEa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hs.2sev/kay^UAS.cEa is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, pnt^P2.UAS

(Weber et al., 2008)

Scer\GAL4^MZ980, Jra^UAS.cEa, kay^UAS.cEa is a non-suppressor of adult thorax | pharate adult stage phenotype of chm¹⁴

(Miotto et al., 2006)

Scer\GAL4^MZ980/kay^UAS.cEa is a non-suppressor of adult thorax | pharate adult stage phenotype of chm¹⁴

(Miotto et al., 2006)

Scer\GAL4^hs.2sev/kay^UAS.cEa is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Ciapponi et al., 2001)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Jra^UAS.cEa, Scer\GAL4^103.3, kay^UAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^103.3, kay^UAS.cEa has dendrite phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has dendrite phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^{nAChRα7-3295}, kay^UAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^{nAChRα7-3295}, kay^UAS.cEa has dendrite phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, kay^UAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, kay^UAS.cEa has dendrite phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^Toll-6-D42, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^Toll-6-D42, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has dendrite phenotype

(Vonhoff et al., 2013)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has synapse phenotype

(Franciscovich et al., 2008)

Jra^UAS.cEa, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P, kay^UAS.cEa has motor neuron phenotype

(Hartwig et al., 2008)

Jra^UAS.cEa, Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK, kay^UAS.cEa has dendrite | somatic clone phenotype

(Hartwig et al., 2008)

Jra^UAS.cEa, Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK, kay^UAS.cEa has larval RP2 motor neuron | somatic clone phenotype

(Hartwig et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav.PH, kay^UAS.cEa has NMJ bouton | somatic clone phenotype

(Haussmann et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav.PH, kay^UAS.cEa has embryonic/larval neuromuscular junction | somatic clone phenotype

(Haussmann et al., 2008)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has neuromuscular junction | larval stage phenotype

(Sanyal et al., 2002)

Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa has bouton | increased number phenotype

(Sanyal et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Larval eye-antennal disc clones co-expressing kay^Scer\UAS.cEa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit hyperplasia but no invasive growth, as compared to controls, and pupae containing these clones die during the P4 or P5 stage.

(Külshammer et al., 2015)

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^D42 in the presence of Scer\GAL80^Cha.PK (to suppress expression in cholinergic neurons) results in a significant increase in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments and dendritic territory borders are unaffected.

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^103.3 results in a significant increase in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments and dendritic territory borders are unaffected.

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^futsch-C380 in the presence of Scer\GAL80^Cha.PK (to suppress expression in cholinergic neurons) results in a significant decrease in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments are unaffected. The dendrites do not reach the normal neuropil boundaries and appear less ramified with several parts missing. The most severe defects are in the proximal-posterior region.

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^gfA-3295 results in a significant reduction in the number of adult MN5 dendrites.

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^futsch-C380 results in significantly fewer dendritic branches in the MN5 motorneurons. If expression is delayed past pupal stage P6 by using the temperature-sensitive Scer\GAL80^ts.αTub84B allele, then no obvious dendritic defects are seen.

(Vonhoff et al., 2013)

The mutant eye phenotype caused by expression of Atf3^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF is is completely suppressed by co-expression of kay^Scer\UAS.cEa.

(Sekyrova et al., 2010)

Co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa pan-neurally under the control of Scer\GAL4^elav-C155 positively regulates synaptic strength.

Co-expression of Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155 increases synaptic size (measured as the number of synaptic boutons) compared to wild-type controls.

Co-expression of Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa rescues the small eye phenotype seen upon expression of kay^Fbz.Scer\UAS in the eye disc using Scer\GAL4^ey.3.5.Exel.

Co-expression of kay^Scer\UAS.cEa and sgg^{A81T.Scer\UAS} pan-neurally under the control of Scer\GAL4^elav-C155 strongly reduces EJC amplitude.

Expression of sgg^EY02862 suppresses the reduced EJC amplitude found upon expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa pan-neurally under the control of Scer\GAL4^elav-C155.

Co-expression of cnk^EY06675 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, significantly reduces synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

Co-expression of Fkbp13^EY02405 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, significantly reduces synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

Co-expression of Pde8^EY10143 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, significantly reduces synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

Co-expression of sgg^EY02862 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, significantly reduces synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

Co-expression of Sdc^EY04602 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, significantly reduces synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

Co-expression of Sema-2a^EY08184 in flies already expressing Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155, does not affect synaptic growth compared to Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa over-expression flies.

(Franciscovich et al., 2008)

Co-expression of both kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa in the RP2 motor neurons (using the Scer\GAL4^eve.RRK driver to drive expression of Scer\FLP1^Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4^Act.PU) results in a significant increase in RP2 dendrite volume compared to controls.

Cultured motor neurons co-expressing both kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^futsch-C380 (in the presence of Scer\GAL80^Cha.PK to suppress expression in cholinergic neurons) show a significant increase in both neurite length and branch number compared to controls.

(Hartwig et al., 2008)

Simultaneous co-expression of Jra^Scer\UAS.cEa and kay^Scer\UAS.cEa under the control of Scer\GAL4^elav.PH in clones induced by FLP/FRT mediated recombination (to activate the Scer\GAL4^elav.PH driver) results in an increase in the number of type 1b boutons at muscle 13 compared to wild type.

(Haussmann et al., 2008)

Co-expression of kay^Scer\UAS.cEa has no effect on the symmetrical ommatidia phenotype caused by expression of pnt^P2.Scer\UAS under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2008)

Coexpression of kay^Scer\UAS.cEa and Mnn1^Scer\UAS.cCa under the control of Scer\GAL4^pnr-MD237 results in an enhancement of the cleft thorax phenotypes seen when either is expressed alone.

(Cerrato et al., 2006)

Expression of both kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa under the control of Scer\GAL4^elav-C155 results in a 30% increase in EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered. Expression of CrebB-17A^b.hs does not change the effect of co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa (under the control of Scer\GAL4^elav-C155) on bouton number, but significantly inhibits the effect of co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa (under the control of Scer\GAL4^elav-C155) on EJC amplitude (synaptic strength); the triple mutant flies have an EJC amplitude 108% that of control flies. Expression of dnc^Scer\UAS.cCa under the control of Scer\GAL4^elav-C155 does not change the effect of co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa (under the control of Scer\GAL4^elav-C155) on bouton number, but significantly inhibits the effect of co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa (under the control of Scer\GAL4^elav-C155) on EJC amplitude (synaptic strength); the triple mutant flies have an EJC amplitude 83% that of control flies. Expression of puc^Scer\UAS.cMa under the control of Scer\GAL4^elav-C155 suppresses the effect of co-expression of kay^Scer\UAS.cEa and Jra^Scer\UAS.cEa (under the control of Scer\GAL4^elav-C155) on bouton number and EJC amplitude (synaptic strength) at the larval neuromuscular junction.

(Sanyal et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^srp.Hemo/kay^UAS.cEa rescues kay²

(Belyaeva et al., 2022)

Partially rescues

Scer\GAL4^69B/kay^UAS.cEa partially rescues kay¹/kay²

(Riesgo-Escovar and Hafen, 1997)

Fails to rescue

Scer\GAL4^pnr-MD237/kay^UAS.cEa fails to rescue kay¹/kay²

(Riesgo-Escovar and Hafen, 1997)

Comments

Scer\GAL4^pnr-MD237-mediated expression in kay¹/kay² transheterozygous embryos fails to rescue the dorsal-open phenotype. Scer\GAL4^69B-mediated expression rescues the embryonic phenotype of kay¹/kay² and partially rescues mutants to pharate adults.

(Riesgo-Escovar and Hafen, 1997)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7213

w¹¹¹⁸; P{UAS-Fra}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Fra^UAS.cEa

kay^Scer\UAS.cEa

kay^UAS.cEa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Eresh

(Eresh et al., 1997)

Secondary FlyBase IDs

References (25)

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