FlyBase Allele Report: Dsim\Lhr[unspecified]

General Information

Symbol

Dsim\Lhr^unspecified

Species

D. simulans

Name

FlyBase ID

FBal0060719

Feature type

allele

Associated gene

Dsim\Lhr

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Dsim\Lhr^unspecified can rescue the sterility of hybrid female progeny of D.melanogaster females crossed to D.simulans males.

(Barbash and Ashburner, 2003)

Hybrid daughters from a cross of D.melanogaster females to D.simulans males are poorly viable at high temperatures (29^o). This female lethality is suppressed by D.simulans Dsim\Lhr^unspecified. Hybrid males from a cross of D.melanogaster females to D.simulans males are not viable. This male lethality is fully rescued at 18^oC and 25^oC and poorly rescued at 29^oC by D.simulans Dsim\Lhr^unspecified. The rescuing activity of D.simulans Dsim\Lhr^unspecified is strongly suppressed by D.melanogaster Dp(1;2)v⁺75d. D.melanogaster Dp(1;2)v⁺75d has no significant effect on hybrid female viability in crosses of D.melanogaster females to D.simulans Dsim\Lhr^unspecified males, suggesting that D.simulans Dsim\Lhr^unspecified suppresses the deleterious effect of Dp(1;2)v⁺75d normally seen in female hybrids.

(Barbash et al., 2000)

Dsim\Lhr^unspecified rescues the viability of hybrid males derived from a cross between D.simulans males and D.melanogaster females.

(Carracedo et al., 2000)

Dsim\Lhr^unspecified rescues D.melanogaster/D.simulans hybrid males (derived from a cross of D.melanogaster females to D.simulans males) that would normally be inviable. Dsim\Lhr^unspecified allows the recovery of significantly more D.melanogaster/D.simulans hybrid males carrying Dp(1;2)v⁺75d and derived from a cross of D.melanogaster attached-X females to D.simulans males than in controls.

(Orr and Irving, 2000)

The sex ratios of progeny from a cross of D.simulans Dsim\Lhr^unspecified males to D.melanogaster prod⁺ or prod^unspecified/+ females are not significantly different from 0.5 or from each other.

(Itoh et al., 1999)

Dsim\Lhr^unspecified rescues hybrid males from a cross between D.melanogaster mit¹ females and Dsim\Lhr^unspecified males. X/O clones are recovered on the head and thorax of the hybrid flies and are larger than the clones produced in a cross between D.melanogaster mit¹ females and Dsim\Lhr⁺ males.

(Orr et al., 1997)

Dsim\Lhr^unspecified does not suppress the lethality of recombinant hybrid clones in D.melanogaster/D.simulans hybrid females.

(Sanchez et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Df(2L)ab-c1/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Df(2L)BSC242/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by PBac{RB}RfC38^e00704/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has fertile phenotype, suppressible | male limited by Dsim\Int(2L)S/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Dsim\Int(2L)S/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by +/Df(2L)FCK-20

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Df(2L)BSC241/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Df(2L)BSC36/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, suppressible | male limited by Df(2L)Exel6027/+

(Sawamura et al., 2010)

NOT suppressed by

Statement

Reference

Dsim\Lhr^unspecified has viable phenotype, non-suppressible | male limited by Df(2L)BSC343/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, non-suppressible | male limited by Df(2L)Exel6028/+

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, non-suppressible | male limited by Nup160^EP372/Nup160[+]

(Sawamura et al., 2010)

Dsim\Lhr^unspecified has viable phenotype, non-suppressible | male limited by l(2)SH2055[+]/Nup160^SH2055

(Sawamura et al., 2010)

Other

Statement

Reference

Df(2L)EP372M190/+, Dsim\Lhr^unspecified has lethal phenotype

(Maehara et al., 2012)

Df(2L)EP372M201/+, Dsim\Lhr^unspecified has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M64 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M75 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M121 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M123 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M85 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M161 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M26 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M39 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M94 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M133 has viable phenotype

(Maehara et al., 2012)

Df(2L)EP372M203/+, Dsim\Lhr^unspecified has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M142 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M185 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M215 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M227 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M180 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M69 has lethal phenotype

(Maehara et al., 2012)

Df(2L)EP372M219/+, Dsim\Lhr^unspecified has lethal phenotype

(Maehara et al., 2012)

Dsim\Int(2L)D, Dsim\Int(2L)S/+, Dsim\Lhr^unspecified has lethal | pupal stage phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372 has viable phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M18 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M25 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M54 has lethal phenotype

(Maehara et al., 2012)

Dsim\Lhr^unspecified/Dsim\Lhr[+], Nup160^EP372M55 has lethal phenotype

(Maehara et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Nup160^EP372M180/Dsim\Lhr^unspecified mutant males are lethal.

Df(2L)EP372M190/Dsim\Lhr^unspecified mutant males are lethal.

Df(2L)EP372M201/Dsim\Lhr^unspecified mutant males are lethal.

Df(2L)EP372M203/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M69/Dsim\Lhr^unspecified mutant males are lethal.

Df(2L)EP372M219/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M18/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M25/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M54/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M55/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M64/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M121/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M85/Dsim\Lhr^unspecified mutant males are lethal.

Nup160^EP372M161/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M26/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M39/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M94/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M185/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M215/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M227/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M133/Dsim\Lhr^unspecified mutant males are viable.

Nup160^EP372M142/Dsim\Lhr^unspecified mutant males are viable.

Dsim\Int(2L)S, Dsim\Int(2L)D/Dsim\Lhr^unspecified mutant males are lethal at the early pupal stage.

(Maehara et al., 2012)

In the progeny of hybrids between Drosophila melanogaster females carrying Dsim\Int(2L)D and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Dsim\Int(2L)D has an effect on male fertility but it does not decrease viability or female fertility.

In the progeny of hybrids between Drosophila melanogaster females carrying Dsim\Int(2L)S and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Dsim\Int(2L)S is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)FCK-20 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)FCK-20 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC241 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)BSC241 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC36 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)BSC36 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)Exel6027 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)Exel6027 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)ab-c1 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)ab-c1 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC242 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)BSC242 is dominant lethal in males.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC343 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)BSC343 is viable in both males and females.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)Exel6028 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Df(2L)Exel6028 is viable in both males and females.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Nup160^EP372 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Nup160^EP372 is viable in both males and females.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for Nup160^SH2055 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, Nup160^SH2055 is viable in both males and females.

In the progeny of hybrids between Drosophila melanogaster females heterozygous for PBac{RB}RfC38^e00704 and Drosophila simulans males homozygous for Dsim\Lhr^unspecified, PBac{RB}RfC38^e00704 is dominant lethal in males.

(Sawamura et al., 2010)

The ability of Dsim\Lhr^unspecified to rescue the hybrid lethality of males derived from a cross of D.melanogaster females to D.simulans males is enhanced if the D.melanogaster females carry one copy of Df(3R)e1025-14, Df(3R)3-4 or Df(3R)kar-Sz12, and is suppressed if the D.melanogaster females carry one copy of Df(2R)AA21.

(Barbash and Lorigan, 2007)

The D.simulans derived polytene X chromosome has a bloated and diffuse appearance in the male hybrid progeny of a cross between attached X D.melanogaster females and Dsim\Lhr^unspecified D.simulans males.

(Pal Bhadra et al., 2006)

X[[mel]]/X[[sim]]; tra^hs.PM hybrids are recovered in crosses of D. melanogaster females to D. simulans males. X[[mel]]/Y[[sim]]; tra^hs.PM hybrids are not recovered in these crosses. X[[mel]]/Y[[sim]]; tra^hs.PM phenotypically female hybrids are recovered if the D. simulans male parent is carrying Dsim\Lhr^unspecified.

(Orr, 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dsim\Lhr^unspecified

Lhr

(Maehara et al., 2012)

unspecified

(Orr et al., 1997, Sanchez et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (13)

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