FB2024_03 , released June 25, 2024
Allele: Dmel\how1A122
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General Information
Symbol
Dmel\how1A122
Species
D. melanogaster
Name
FlyBase ID
FBal0061367
Feature type
allele
Associated gene
Dmel\how
Associated Insertion(s)
P{lArB}how1A122
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lo and Frasch, 1997, Zaffran et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{lArB}how1A122
Cytology
Description

Insertion of a P{lArB} element in the first intron, 354bp downstream of the first exon.

(Lo and Frasch, 1997)
Allele components
Component
Use(s)
Inserted element
P{lArB}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing produce blisters of variable size which can be located anywhere on the wing blade. These are fluid filled in newly eclosed flies and eventually collapse as the flies mature. Veins and interveins within the blisters appear normal. Flies containing homozygous clones in the wing have impaired flight ability, even if the wings only contain small blisters. Homozygous clones in the eye do not disrupt eye morphogenesis.

      (Lo and Frasch, 1997)

      Transheterozygotes with how13 and how15 are viable and produce fertile healthy adults that are unable to fly and hold their wings horizontal at 90o angle from the body axis.

      (Zaffran et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      howstru-3R-3

      (Lo and Frasch, 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      how1A122
      stru1A122
      (Lo and Frasch, 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)