FlyBase Allele Report: Dmel\numb[SW]

General Information

Symbol

Dmel\numb^SW

Species

D. melanogaster

Name

FlyBase ID

FBal0082383

Feature type

allele

Associated gene

Dmel\numb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wang et al., 1997)

Mutagen

Delta2-3 transposase

(Wang et al., 1997)

Progenitor genotype

numb¹

(Wang et al., 1997)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Wang et al., 1997)

visible

(Wang et al., 1997)

Phenotype Manifest In

sensory neuron

(Wang et al., 1997)

tormogen cell

(Wang et al., 1997)

trichogen cell

(Wang et al., 1997)

Detailed Description

Statement

Reference

100% of heterozygous flies show rhythmic locomotor activity, with a period of 24.4 +/- 0.0 hours. 88% of homozygous flies show rhythmic locomotor activity, with a period of 24.9 +/- 0.2 hours. 92% of numb^nuts/numb^SW flies show rhythmic locomotor activity, with a period of 24.7 +/- 0.1 hours. 93% of numb¹/numb^SW flies show rhythmic locomotor activity, with a period of 24.6 +/- 0.1 hours. 94% of numb²/numb^SW flies show rhythmic locomotor activity, with a period of 24.3 +/- 0.1 hours. 79% of numb³/numb^SW flies show rhythmic locomotor activity, with a period of 24.6 +/- 0.1 hours.

(Stempfl et al., 2002)

Both macrochaetae and microchaetae exhibit abnormal external sensory structures. Homozygotes exhibit a weak double-socket phenotype, bristles are produced at the expense of a hair. The severity of the phenotype varies with the genotype. Adult sensory organs also show transformation of the neuron into a sheath.

(Wang et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

numb^SW has visible phenotype, enhanceable by H^B55

(Wang et al., 1997)

numb^SW has visible phenotype, enhanceable by H^DEB1

(Wang et al., 1997)

numb^SW has visible phenotype, enhanceable by H^B21

(Wang et al., 1997)

numb^SW has visible phenotype, enhanceable by H^D9

(Wang et al., 1997)

Suppressed by

Statement

Reference

numb^SW has visible phenotype, suppressible by Su(H)⁸

(Wang et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

numb^SW has trichogen cell phenotype, enhanceable by H^B55

(Wang et al., 1997)

numb^SW has trichogen cell phenotype, enhanceable by H^DEB1

(Wang et al., 1997)

numb^SW has trichogen cell phenotype, enhanceable by H^B21

(Wang et al., 1997)

numb^SW has trichogen cell phenotype, enhanceable by H^D9

(Wang et al., 1997)

Suppressed by

Statement

Reference

numb^SW has trichogen cell phenotype, suppressible by Su(H)⁸

(Wang et al., 1997)

Other

Statement

Reference

Klp98A[+]/Klp98A^Δ47, numb^SW/numb² has tormogen cell | adult stage phenotype

(Derivery et al., 2015)

Klp98A^Δ6/Klp98A^Δ47, numb^SW/numb² has tormogen cell | adult stage phenotype

(Derivery et al., 2015)

Klp98A^Δ8/Klp98A^Δ47, numb^SW/numb² has tormogen cell | adult stage phenotype

(Derivery et al., 2015)

Klp98A^Δ6/Klp98A^Δ47, numb^SW/numb¹⁵ has tormogen cell | adult stage phenotype

(Derivery et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Klp98A^Δ47/+;numb²/numb^SW or Klp98A^Δ47/+;numb^SW/numb¹⁵ mutants have a multiple socket phenotype on the notum; this phenotype is suppressed in Klp98A^Δ47/Klp98A^Δ6;numb²/numb^SW, Klp98A^Δ47/Klp98A^Δ8;numb²/numb^SW or Klp98A^Δ47/Klp98A^Δ6;numb¹⁵/numb^SW double mutants.

(Derivery et al., 2015)

Su(H)⁸ mutation dominantly suppresses the double socket phenotype, but not the double sheath phenotype, of numb^SW/numb² mutants. Su(H)⁸ does not suppress the phenotype of numb^SW homozygotes. Removing one copy of H greatly enhances the double socket phenotype of homozygotes.

(Wang et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

numb^SW

(Derivery et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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