FB2024_03 , released June 25, 2024
Allele: Dmel\Fas3HF-ET
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General Information
Symbol
Dmel\Fas3HF-ET
Species
D. melanogaster
Name
FlyBase ID
FBal0083473
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The aCC growth cone extends normally through the ISN pathway and reliably selects its normal target muscle in Fas3HF-ET flies, despite misexpressing Fas3 during axon pathfinding and target selection. SNa innervation is normal in Fas3HF-ET flies, despite misexpression of Fas3 in the SNa motorneurons during axon pathfinding. Muscle 1 lacks innervation in 4% of cases in embryos carrying both Fas3Mhc.PC and Fas3HF-ET. The aCC growth cone stops short of muscle 1 and instead bends its head slightly posteriorly along muscle 2 in 25% of cases in these embryos. Muscle 1 lacks innervation in 12% of cases in embryos carrying both Fas3Mhc.PC and Fas3HF-ET and expressing Fas3hs.PK (which is present in the P{hs-Fas3.K}HF-ET insertion) due to heat shock. The aCC growth cone mistargets muscle 2 in 30% of cases in these embryos. Abnormal axon collaterals stem out of the SNa nerve in 17% of cases in 18 hour embryos carrying both Fas3Mhc.PC and Fas3HF-ET. These collaterals are thin, probably consisting of only one or two axons, and misinnervate muscles 12, 13, 26 or 27.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
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Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Fas3HF-ET
Name Synonyms
Secondary FlyBase IDs
    References (1)