FB2024_03 , released June 25, 2024
Allele: Dmel\Inx2G0118
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General Information
Symbol
Dmel\Inx2G0118
Species
D. melanogaster
Name
FlyBase ID
FBal0096818
Feature type
allele
Associated gene
Dmel\Inx2
Associated Insertion(s)
P{lacW}Inx2G0118
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Mukai et al., 2011)
Mutagen
P-element activity
(Schäfer et al., 1999.3.29)
Progenitor genotype
Associated Insertion(s)
P{lacW}Inx2G0118
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ426743
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Large follicle stem cell clones block the formation of egg chambers. The differentiation of the mutant follicle cells appears unaffected in these clones: they maintain columnar shape, adhere to each other and form an epithelial sheet. However, the cells fail to associate with germline cells to form egg chambers. Small homozygous follicle cell clones are able to surround cysts with Inx2[+] follicle cells to form nascent egg chambers. Homozygous germline clones are able to form egg chambers with follicle cells.

      (Mukai et al., 2011)

      Lethality occurs during the first larval instar.

      (Peter et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.3.29)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Inx2G0118
      inx2G0118
      (Luedke et al., 2024, Mukai et al., 2011)
      l(1)G0118
      (Peter et al., 2002)
      l(1)G0118G0118
      (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)