FB2024_03 , released June 25, 2024
Allele: Dmel\IntS4G0095
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General Information
Symbol
Dmel\IntS4G0095
Species
D. melanogaster
Name
FlyBase ID
FBal0096825
Feature type
allele
Associated gene
Dmel\IntS4
Associated Insertion(s)
P{lacW}IntS4G0095
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.3.29)
Progenitor genotype
Associated Insertion(s)
P{lacW}IntS4G0095
Cytology
Description

P{lacW}IntS4G0095 is inserted in the second exon of IntS4, disrupting the conserved arm-type fold, housing the HEAT repeats. This insertion is predicted to cause a C-terminal truncation.

(Ezzeddine et al., 2011)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ426791
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      IntS4G0095 homozygotes die at the junction of the 2nd- and 3rd-instar larval stages (with only a small percentage progressing to 2rd instar).

      (Ezzeddine et al., 2011)

      Mutants die at the L3 moult.

      (Peter et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      Nrgibx

      (Carhan et al., 2005)

      Nrgl10

      (Carhan et al., 2005)
      Comments

      The reduced female receptivity phenotype of Nrgibx is complemented by IntS4G0095.

      (Carhan et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.3.29)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IntS4G0095
      l(1)G0095
      (Carhan et al., 2005, Peter et al., 2002)
      l(1)G0095G0095
      Name Synonyms
      Secondary FlyBase IDs
        References (4)