CCT6G0022 homozygotes exhibit cardiac dysfunction under either Light:Light or Light:Dark cycles, as shown by significant increases in heart period, arrhythmia, and diastolic and systolic intervals, and by small decreases in fractional shortening, and diastolic and systolic diameter, as compared to controls.
In contrast to wild type, Tcp-1ζG0022 mutant flies subjected to 12-hour daytime-restricted feeding (TRF) do not exhibit improved cardiac contractility relative to genotype and age-matched ad libitum feeding (ALF) flies, as measured by heart period and arrhythmicity.
P{lacW} not verified as causing the lethality.