FlyBase Allele Report: Dmel\aos[UAS.cMa]

General Information

Symbol

Dmel\aos^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Michelson

FlyBase ID

FBal0098779

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

Carried in Construct

P{UAS-argos.M}

Also Known As

UAS-Argos, UAS-aos

Key Links

Transgenic product class

wild_type

(Michelson, 1999.8.9)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Michelson, 1999.8.9)

Mutagen

in vitro construct

(Michelson, 1999.8.9)

Progenitor genotype

Carried in construct

P{UAS-argos.M}

Cytology

Description

UAS regulatory sequences drive expression of aos.

(Michelson, 1999.8.9)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

aos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

visible, with Scer\GAL4^Bx-MS1096

(Hogan et al., 2011, Coelho et al., 2005)

visible, with Scer\GAL4^Dll-md23

(Galindo et al., 2002)

visible, with Scer\GAL4^dpp.blk1

(Grieder et al., 2007)

visible, with Scer\GAL4^en-e16E

(Rawlings et al., 2004)

visible, with Scer\GAL4^unspecified

(Michelson, 1999.8.9)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^en-e16E

(Rawlings et al., 2004)

crossvein, with Scer\GAL4^dpp.blk1

(Grieder et al., 2007)

eye, with Scer\GAL4^unspecified

(Michelson, 1999.8.9)

glial cell & antennal disc, with Scer\GAL4^hs.PB

(Sen et al., 2004)

mesothoracic tergum, with Scer\GAL4^{Ubx-lac1-Gal4}

(Pallavi and Shashidhara, 2003)

posterior crossvein, with Scer\GAL4^en-e16E

(Rawlings et al., 2004)

pretarsus, with Scer\GAL4^Dll-md23

(Galindo et al., 2002)

wing, with Scer\GAL4^Bx-MS1096

(Marygold et al., 2011, Coelho et al., 2005)

wing, with Scer\GAL4^{Ubx-lac1-Gal4}

(Pallavi and Shashidhara, 2003)

wing disc, with Scer\GAL4^ap-md544

(Pallavi and Shashidhara, 2003)

wing disc, with Scer\GAL4^tsh-md621

(Pallavi and Shashidhara, 2003)

wing disc, with Scer\GAL4^{Ubx-lac1-Gal4}

(Pallavi and Shashidhara, 2003)

wing vein, with Scer\GAL4^Bx-MS1096

(Hogan et al., 2011, Marygold et al., 2011, Coelho et al., 2005)

wing vein L3, with Scer\GAL4^dpp.blk1

(Grieder et al., 2007)

wing vein L4, with Scer\GAL4^en-e16E

(Rawlings et al., 2004)

Detailed Description

Statement

Reference

Overexpression of aos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096 results in variable loss of dorsal longitudinal wing veins including L3.

(Hogan et al., 2011)

Expression of aos^Scer\UAS.cMa using Scer\GAL4^Bx-MS1096 results in an abnormally small wing with missing veins.

(Marygold et al., 2011)

Flies expressing argos^Scer\UAS.cMa under the control of Scer\GAL4^dpp.blk1 lack crossveins and have a gap in vein L3.

(Grieder et al., 2007)

Expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096 results in wing vein loss and a small wing phenotype.

(Coelho et al., 2005)

Expression of argos^Scer\UAS.cMa under the control of Scer\GAL4¹¹⁵¹ does not affect founder cell formation of patterning.

(Dutta et al., 2005)

Expression of argos^Scer\UAS.cMa in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

(Medioni and Noselli, 2005)

Expression of two copies of argos^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E results in wings which lack vein L4 and both crossveins. Expression of one copy of argos^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E results in a milder wing vein loss phenotype.

(Rawlings et al., 2004)

When argos^Scer\UAS.cMa is driven by Scer\GAL4^hs.PB and heatshocked between 14 and 15 hours after puparium formation, a severe reduction is seen in numbers of antennal glia.

(Sen et al., 2004)

argos^Scer\UAS.cMa with Scer\GAL4^pnr-MD237, Scer\GAL4⁴²⁶ or Scer\GAL4^Gug-AGiR does not affect wing disc development. argos^Scer\UAS.cMa with Scer\GAL4^ap-md544 or Scer\GAL4^tsh-md621 causes severe reduction in notum tissue in the 3rd instar wing disc; however, no transformation of notum to wing fate is observed in these discs. argos^Scer\UAS.cMa; Scer\GAL4^{Ubx-lac1-Gal4}adults exhibit wing duplication in the posterior compartment and partial loss of notum and/or hinge. Occasionally pharate adults die within the pupal case, with severe loss of notum tissue. In larvae of this genotype, the wing discs show altered morphology, particularly overgrowth in the posterior hinge and mesonotum. Marker analysis indicates formation a new wing pouch complete with the DV boundary, and that pattern duplication is associated with loss of notum, confirming notum/hinge-to-wing transformations.

(Pallavi and Shashidhara, 2003)

Flies expressing argos^Scer\UAS.cMa under the control of Scer\GAL4^Dll-md23 lack the pretarsus (including the claw). Tarsal segment 5 is reduced.

(Galindo et al., 2002)

Shows a rough eye phenotype when crossed to an (unspecified) eye disk Scer\GAL4 driver.

(Michelson, 1999.8.9)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi^E90/ebi[+]

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi[+]/ebi^CC3

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi[+]/ebi^CCS-8

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi[+]/ebi^E4

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi^Δ1/ebi[+]

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, enhanceable by ebi[+]/ebi^W418X

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by E-3c1[+]/E-3c1¹

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by RpL38[+]/RpL38^2b2

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by RpL5^2d1/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by RpL5^2d2/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by lep^3c5/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by lep^3c6/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by ncm^2a2/ncm[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by E-3c4[+]/E-3c4⁴

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by pix^3c2/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by pix^3c3/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by ncm[+]/ncm^2a1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by E-3c7⁷/E-3c7[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by prp8[+]/Prp8^2e1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by Prp8^2e2/prp8[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has visible phenotype, enhanceable by RpL38[+]/RpL38^2b1

(Coelho et al., 2005)

Scer\GAL4^en-e16E, aos^UAS.cMa has visible phenotype, enhanceable by +/Df(2R)CA53

(Rawlings et al., 2004)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, non-enhanceable by ebi[+]/ebi^k16213

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, non-enhanceable by ebi[+]/ebi^WKS-24

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has abnormal size phenotype, non-enhanceable by ebi[+]/ebi^P7

(Marygold et al., 2011)

Scer\GAL4^en-e16E, aos^UAS.cMa has visible phenotype, non-enhanceable by Df(2R)Drl^rv18/+

(Rawlings et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, aos^UAS.cMa has visible phenotype, suppressible | partially by Socs44A^UAS.cRa/Scer\GAL4^en-e16E

(Rawlings et al., 2004)

NOT suppressed by

Statement

Reference

Scer\GAL4^en-e16E, aos^UAS.cMa has visible phenotype, non-suppressible by Df(2R)Drl^rv18/+

(Rawlings et al., 2004)

Suppressor of

Statement

Reference

aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-Gal4} is a suppressor of visible | homeotic phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

Other

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa, pk³⁰ has visible phenotype

(Hogan et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi^E90/ebi[+]

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi[+]/ebi^CC3

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi[+]/ebi^CCS-8

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi[+]/ebi^E4

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi^Δ1/ebi[+]

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by ebi[+]/ebi^W418X

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, enhanceable by E-3c1[+]/E-3c1¹

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by RpL38[+]/RpL38^2b1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by RpL38[+]/RpL38^2b2

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by RpL5^2d1/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by E-3c1[+]/E-3c1¹

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by RpL5^2d2/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by lep^3c5/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by lep^3c6/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by ncm^2a2/ncm[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by pix^3c2/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by pix^3c3/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by ncm[+]/ncm^2a1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by E-3c4[+]/E-3c4⁴

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by prp8[+]/Prp8^2e1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by Prp8^2e2/prp8[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing phenotype, enhanceable by E-3c7⁷/E-3c7[+]

(Coelho et al., 2005)

Scer\GAL4^en-e16E, aos^UAS.cMa has wing vein phenotype, enhanceable by +/Df(2R)CA53

(Rawlings et al., 2004)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by ebi[+]/ebi^k16213

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by ebi[+]/ebi^WKS-24

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by ebi[+]/ebi^P7

(Marygold et al., 2011)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by RpL38[+]/RpL38^2b1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by RpL38[+]/RpL38^2b2

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by RpL5^2d1/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by RpL5^2d2/RpL5[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by lep^3c5/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by lep^3c6/lep[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by ncm^2a2/ncm[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by pix^3c2/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by pix^3c3/pix[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by ncm[+]/ncm^2a1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by E-3c4[+]/E-3c4⁴

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by prp8[+]/Prp8^2e1

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by Prp8^2e2/prp8[+]

(Coelho et al., 2005)

Scer\GAL4^Bx-MS1096, aos^UAS.cMa has wing vein phenotype, non-enhanceable by E-3c7⁷/E-3c7[+]

(Coelho et al., 2005)

Scer\GAL4^en-e16E, aos^UAS.cMa has wing vein phenotype, non-enhanceable by Df(2R)Drl^rv18/+

(Rawlings et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, aos^UAS.cMa has posterior crossvein phenotype, suppressible by Socs44A^UAS.cRa/Scer\GAL4^en-e16E

(Rawlings et al., 2004)

Scer\GAL4^en-e16E, aos^UAS.cMa has wing vein L4 phenotype, suppressible | partially by Socs44A^UAS.cRa/Scer\GAL4^en-e16E

(Rawlings et al., 2004)

NOT suppressed by

Statement

Reference

Scer\GAL4^en-e16E, aos^UAS.cMa has wing vein phenotype, non-suppressible by Df(2R)Drl^rv18/+

(Rawlings et al., 2004)

Suppressor of

Statement

Reference

aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-Gal4} is a suppressor of capitellum phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

aos^UAS.cMa/Scer\GAL4^{Ubx-lac1-Gal4} is a suppressor of wing margin bristle | ectopic phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

Other

Statement

Reference

Scer\GAL4^Bx-MS1096, aos^UAS.cMa, pk³⁰ has wing vein phenotype

(Hogan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of aos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096 in homozygous pk³⁰ mutants induces partial loss of longitudinal wing veins. The discontinuity in hair and ridge orientation maps to the site of the L3 vein.

(Hogan et al., 2011)

Heterozygosity for ebi^2g2, ebi^E90, ebi^CC3, ebi^2g1, ebi^CCS-8, ebi^E4, ebi^Δ1 or ebi^W418X enhances the small wing and wing vein loss phenotypes induced by Scer\GAL4^Bx-MS1096-mediated expression of aos^Scer\UAS.cMa.

(Marygold et al., 2011)

Expression of argos^Scer\UAS.cMa completely suppresses the haltere-to-wing transformation of Ubx^lac1-GAL4/+ flies.

(Pallavi et al., 2006)

Co-expression of Socs44A^Scer\UAS.cRa partially suppresses the loss of wing vein phenotype that is seen in flies expressing two copies of argos^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E; the posterior crossvein and the most proximal and distal parts of wing vein L4 are restored.

Co-expression of one copy of Socs44A^Scer\UAS.cRa and one copy of argos^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E results in an almost wild-type wing.

The severity of the wing vein loss phenotype caused by expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is enhanced by Df(2R)CA53/+, but is not affected by Df(2R)Drl^rv18/+.

(Rawlings et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5363