FB2024_03 , released June 25, 2024
Allele: Dmel\brkF124
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General Information
Symbol
Dmel\brkF124
Species
D. melanogaster
Name
FlyBase ID
FBal0105065
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ssg-1F124
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: R82W.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C7308716T

Amino acid change:

R82W | brk-PA

Reported amino acid change:

R82W

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

brkF124 larvae have essentially the same denticle phenotype as brkM68 larvae, although the residual denticle belts are slightly broader.

Alterations in the pattern of the denticle belts are seen in mutant embryos; the denticle belts often have fewer rows of setae than normal as the anterior rows are absent. Salivary glands are small and remain in the anteriormost position of older embryos due to head defects.

Male escapers have ectopic wing veins. In brkF124 mutant embryos, small salivary glands are found in the anterior head region. The salivary glands are also not fully invaginated and the invagination appears delayed compared to wild-type. However in the resulting smaller salivary glands a lumen can often be detected indicating that final morphogenesis is unaffected. No evidence for cell death is found. In brkF124 mutant larvae, the trapezoid form of the abdominal denticle belts is lost and denticle belts appear slightly narrowed in the dorsal ventral extent when compared to wild-type. The anterior row of setae is preferentially missing and a few single scattered setae are formed instead. the loss of setae in the first abdominal denticle rows is more pronounced in the anterior abdominal segments than in the more posterior segments. In the nervous system of brkF124 mutant embryos, the longitudinal connectives appear thinner and breaks can often be found. Commissures form normally but sometimes have an irregular shape.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
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Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)