FB2024_03 , released June 25, 2024
Allele: Dmel\to1
Open Close
General Information
Symbol
Dmel\to1
Species
D. melanogaster
Name
FlyBase ID
FBal0117331
Feature type
allele
Associated gene
Dmel\to
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    The 3' end of the coding region is absent.

    (Sarov-Blat et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        to1 flies feed more than control flies. This is because they feed at a greater frequency, rather than by increasing the volume of intake per proboscis extension.

        (Wong et al., 2009)

        Homozygotes show a significant reduction in courtship index. Males do not display male-chaining behaviour.

        (Dauwalder et al., 2002)

        to1 flies exhibit defects in both circadian activity and survival in starvation conditions. In two days without food mutants show only two peaks of activity (compared to at least three in wild-type) and the average death time is 20 hours (instead of 30 hours in wild-type). however the mutants are more active during the activity decline that follows the first activity peak.

        (Sarov-Blat et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        fru3, to1 has abnormal courtship behavior phenotype, suppressible by Tp(3;Y)A81

        (Dauwalder et al., 2002)

        fru3, to1 has abnormal courtship behavior phenotype, suppressible by Tp(3;Y)L58

        (Dauwalder et al., 2002)
        Enhancer of
        Statement
        Reference

        to1/to1 is an enhancer of abnormal courtship behavior phenotype of fru3

        (Dauwalder et al., 2002)

        to1/to1 is an enhancer of abnormal courtship behavior phenotype of fru4

        (Dauwalder et al., 2002)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of toScer\UAS.cLa, under the control of Scer\GAL4oeE in fru4/+, to1/to1 flies suppresses the mutant courtship phenotype.

        (Lazareva et al., 2007)

        The addition of to1/to1 to fru4/+ or fru3/+ leads to a significant reduction in courtship index. Although reduced courtship is not abolished, Mutant males are capable of all stages of courtship, but perform less frequently. This reduction is not caused by a reduction in general activity. The addition of the fru carrying Tp(3;Y)A81 or Tp(3;Y)L58 rescues this enhancement phenotype.

        (Dauwalder et al., 2002)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Separable from: ry506.

        (Sarov-Blat et al., 2000)

        Identified in "Bloomington stock number 2541 (snw; ry506)", The original stock containing the to1 allele also appears to contain suppressors of the courtship behaviour phenotype as homozygotes do not have this phenotype until the chromosome has been cleaned up.

        (Dauwalder et al., 2002)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        ry506
        (Stanewsky, 2003)
        ry506 strain
        (Sarov-Blat et al., 2000)
        to1
        (Saurabh et al., 2018, Lazareva et al., 2007)
        Name Synonyms
        takeout1
        (Wong et al., 2009)
        Secondary FlyBase IDs
          References (7)