FB2024_02 , released April 23, 2024
Allele: Dmel\blwKG05893
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General Information
Symbol
Dmel\blwKG05893
Species
D. melanogaster
Name
FlyBase ID
FBal0137295
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous blwKG05893 mutants are smaller than controls (at the same stage), with the majority dying at the second instar larval stage, with 20-30% of larvae reaching the third instar. Examination of the fat body in third instar larvae reveals a dramatic reduction in thickness and a significant reduction in the ratio of triglyceride-to-protein content. Overall mitochondrial number is not affected in these mutants. Staining with Mitotracker suggests functional defects in these mitochondria. These mitochondria also exhibit alterations in diameter and length compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

blwKG05893 is an enhancer of eye | temperature conditional phenotype of InvadolysinUAS.N.Tag:HA, Scer\GAL4GMR.PF

blwKG05893 is an enhancer of ommatidium | temperature conditional phenotype of InvadolysinUAS.N.Tag:HA, Scer\GAL4GMR.PF

blwKG05893 is an enhancer of interommatidial bristle | temperature conditional phenotype of InvadolysinUAS.N.Tag:HA, Scer\GAL4GMR.PF

Additional Comments
Genetic Interactions
Statement
Reference

A blwKG05893 mutant background enhances the rough eye phenotype seen in adult eyes upon expression of InvadolysinScer\UAS.N.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF at 29[o]C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)