FlyBase Allele Report: Dmel\mTor[TED.UAS]

Late pupae expressing Tor^TED.Scer\UAS under the control of Scer\GAL4^ninaE.PU and reared in constant light conditions do not present any obvious defects in rhabdomere structure or in endomembranes in photoreceptors, as compared to controls.

(Kamalesh et al., 2017)

Scer\GAL4^bs.PM-mediated expression of Tor^TED.Scer\UAS results in decreased terminal cell branching and induction of long, branched autocellular, seamed tubes extend well beyond the terminal cell nucleus.

(Francis and Ghabrial, 2015)

Tor^TED.Scer\UAS-expressing clones (generated using MARCM and Scer\GAL4^ppk.PG) show relatively mild dendrite growth defects in the large C4da dendritic arbors.

(Lin et al., 2015)

Expression of snama^NIG.3231R under the control of Scer\GAL4^elav-C155 marginally increases bouton size compared to controls.

(Deivasigamani et al., 2014)

Cells in clones expressing Tor^TED.Scer\UAS under the control of Scer\GAL4^Act.PU in the fat body are much smaller in size than wild-type cells and have tiny nuclei.

Expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 results in shortened, misshaped wings.

(Mukherjee and Duttaroy, 2013)

In contrast to wild-type, transgenic flies expressing Scer\GAL4^ppl.PP>Tor^TED.Scer\UAS and reared on medium supplemented with Apis mellifera royal jelly do not show increased body size. However, similarly to wild-type flies in response to royal jelly, they display shortened developmental time compared with flies reared on control medium.

(Kamakura, 2011)

Expression of Tor^TED.Scer\UAS using Scer\GAL4^en.PU results in a significant increase in the fraction of mitotic cells in the posterior compartment of the wing disc.

Expression of Tor^{WT.Scer\UAS.T:Zzzz\FLAG} using Scer\GAL4^en.PUinduces only very low levels of apoptosis in the the wing disc.

Expression of Tor^TED.Scer\UAS using Scer\GAL4^nub-AC-62 results in abnormally small wings in which cell size and cell number are decreased.

Expression of Tor^TED.Scer\UAS using Scer\GAL4^nub-AC-62, Scer\GAL4^en.PU or Scer\GAL4^MD-638 results in a severe reduction in wing size.

(Resnik-Docampo and de Celis, 2011)

Expression of Tor^TED.Scer\UAS under the simultaneous control of both Scer\GAL4^Scer\UAS.cHa and Scer\GAL4^tin.cBa does not rescue the increase in triglyceride levels caused by a high-fat diet. However, the heart defects normally caused by a high-fat diet are rescued in these animals.

(Birse et al., 2010)

Expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Lsp2.PH induces autolysosome formation in the fat body.

(Haberman et al., 2010)

Expression of Tor^TED.Scer\UAS in the eye under the control of Scer\GAL4^GMR.PU results in retinal degeneration. At 14 days old, degenerating photoreceptor cells display large autophagosomes.

(Nisoli et al., 2010)

Animals expressing Tor^TED.Scer\UAS under the control of Scer\GAL4^da.G32 do not eclose to adulthood.

(Kapahi et al., 2004)

When expression is driven by Scer\GAL4^Lsp2.PH, in the larval fat body, autolysosomes show a marked increase in size (up to 10 microns), a 30% increase in autophagic area, a reduction of cytoplasmic area and disappearance of structures labelled with Hsap\MLP3B^{Scer\UAS.T:Avic\GFP-EGFP} alone. Autolysosomal structures are less acidic than in wild type. Fat droplets accumulate, abnormally.

(Rusten et al., 2004)

When Tor^TED.Scer\UAS is driven by Scer\GAL4^ppl.PP in the fat body vesicle aggregation and restricted endoreduplication is seen. This is associated with a developmental delay and a weak growth defect.

(Colombani et al., 2003)

Expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 results in smaller wings than normal which show an upward curvature. The flies show a developmental delay. Expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^en-e16E results in a developmental delay and a reduced posterior wing.

(Hennig and Neufeld, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, mTor^TED.UAS has decreased cell number phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^nub-AC-62, mTor^TED.UAS has decreased cell size phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^nub-AC-62, mTor^TED.UAS has abnormal size phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Suppressed by

Statement

Reference

Scer\GAL4^Act.PU, mTor^TED.UAS has decreased cell size | somatic clone phenotype, suppressible | partially | somatic clone by Scer\GAL4^Act.PU/srl^EY05931

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible by Scer\GAL4^Act.PU/srl^EY05931

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^nub-AC-62, mTor^TED.UAS has abnormal size phenotype, suppressible by hppy^GD12129/Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^MD-638, mTor^TED.UAS has abnormal size phenotype, suppressible by hppy^GD12129/Scer\GAL4^MD-638

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible by Df(3R)DG2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^Bx-MS1096

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible by Df(3L)Rdl-2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible by Df(3L)kto2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has visible phenotype, suppressible by Df(3L)st-f13/+

(Hennig and Neufeld, 2002)

Enhancer of

Statement

Reference

Scer\GAL4^nub-AC-62/mTor^TED.UAS is an enhancer of abnormal size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^nub-AC-62/mTor^TED.UAS is an enhancer of decreased cell number phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^nub-AC-62/mTor^TED.UAS is an enhancer of decreased cell size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Suppressor of

Statement

Reference

mTor^TED.UAS/Scer\GAL4^hs.PB is a suppressor of increased cell number | pupal stage phenotype of hrm^Δ1

(Velentzas et al., 2018)

mTor^TED.UAS, Scer\GAL4^NP0001 is a suppressor of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

mTor^TED.UAS, Scer\GAL4^Tub.PU is a suppressor | partially of lethal - all die during P-stage phenotype of AMPKα^JF01951, Scer\GAL4^Tub.PU

(Onyenwoke et al., 2015)

Scer\GAL4^elav-C155/mTor^TED.UAS is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

mTor^TED.UAS, Scer\GAL4^αTub84B.PL is a suppressor | partially of lethal | larval stage phenotype of AMPKα^RNAi.UAS, Scer\GAL4^αTub84B.PL

(Johnson et al., 2010)

mTor^TED.UAS, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

mTor^TED.UAS, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/mTor^TED.UAS is a non-suppressor | somatic clone of abnormal neuroanatomy | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Scer\GAL4^Tub.PU/mTor^TED.UAS is a non-suppressor of lethal - all die during P-stage | recessive phenotype of AMPKα¹

(Onyenwoke et al., 2015)

Scer\GAL4^Tub.PU/mTor^TED.UAS is a non-suppressor of lethal - all die during P-stage | recessive phenotype of AMPKα³

(Onyenwoke et al., 2015)

Scer\GAL4^elav-C155/mTor^TED.UAS is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, Vap33^UAS.cRa

(Deivasigamani et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, mTor^TED.UAS has wing phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible by Scer\GAL4^Act.PU/srl^EY05931

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^nub-AC-62, mTor^TED.UAS has wing phenotype, suppressible by hppy^GD12129/Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^MD-638, mTor^TED.UAS has wing phenotype, suppressible by hppy^GD12129/Scer\GAL4^MD-638

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^Lsp2.PH, mTor^TED.UAS has fat body phenotype, suppressible by Acn²⁷/Acn¹

(Haberman et al., 2010)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible by Df(3L)Rdl-2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible by Df(3L)kto2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible by Df(3L)st-f13/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible by Df(3R)DG2/+

(Hennig and Neufeld, 2002)

Scer\GAL4^Bx-MS1096, mTor^TED.UAS has wing phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^Bx-MS1096

(Hennig and Neufeld, 2002)

Enhancer of

Statement

Reference

Scer\GAL4^nub-AC-62/mTor^TED.UAS is an enhancer of wing phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

mTor^TED.UAS, Scer\GAL4^GMR.PU is an enhancer of autophagosome phenotype of Gug^75QN.UAS, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

mTor^TED.UAS, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^75QN.UAS, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

mTor^TED.UAS, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^66QC.UAS, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

mTor^TED.UAS, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^UAS.cCa, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

NOT Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/mTor^TED.UAS is a non-enhancer of eye phenotype of cathD¹

(Kuronen et al., 2009)

Suppressor of

Statement

Reference

mTor^TED.UAS/Scer\GAL4^hs.PB is a suppressor of salivary gland | pupal stage phenotype of hrm^Δ1

(Velentzas et al., 2018)

mTor^TED.UAS, Scer\GAL4^NP0001 is a suppressor of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Scer\GAL4^elav-C155/mTor^TED.UAS is a suppressor of terminal bouton phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

mTor^TED.UAS, Scer\GAL4^ppk.PG is a suppressor | partially of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Cul1^GD9650, Scer\GAL4^ppk.PG

(Wong et al., 2013)

mTor^TED.UAS, Scer\GAL4^repo.PU is a suppressor of glial cell | increased number | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

mTor^TED.UAS, Scer\GAL4^repo.PU is a suppressor of embryonic/larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

mTor^TED.UAS, Scer\GAL4^fkh.PH is a suppressor of embryonic/larval salivary gland phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

mTor^TED.UAS, Scer\GAL4^fkh.PH is a suppressor | partially of embryonic/larval salivary gland phenotype of Ras85D^V12.UAS, Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/mTor^TED.UAS is a non-suppressor | somatic clone of neuroblast | ectopic | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Scer\GAL4^Tub.PU/mTor^TED.UAS is a non-suppressor | somatic clone of adult optic lobe | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Scer\GAL4^elav-C155/mTor^TED.UAS is a non-suppressor of terminal bouton phenotype of Scer\GAL4^elav-C155, Vap33^UAS.cRa

(Deivasigamani et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Tor^TED.Scer\UAS suppresses the increased midgut cell size resulting from the expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

Clonal expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^tub.PU fails to suppress the formation of ectopic neuroblasts in larval optic lobe nerfin-1¹⁵⁹/nerfin-1¹⁵⁹ mutant clones.

(Xu et al., 2017)

The late pupal lethality observed in animals expressing AMPKα^JF01951 under the control of Scer\GAL4^tub.PU can be partially rescued by co-expression of Tor^TED.Scer\UAS.

The pupal-stage lethality of either hemizygous AMPKα¹ or AMPKα³ males cannot be rescued by expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^tub.PU.

(Onyenwoke et al., 2015)

Expression of Tor^TED.Scer\UAS suppresses the enlarged bouton phenotype seen when Vap-33A^{P58S.cRa.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Tor^TED.Scer\UAS does not suppress the small bouton phenotype seen when Vap-33A^Scer\UAS.cRa is expressed under the control of Scer\GAL4^elav-C155.

(Deivasigamani et al., 2014)

Co-expression of srl^EY05931 significantly increases cell size (both nuclear area and cytoplasmic area) in clones in the fat body expressing Tor^TED.Scer\UAS under the control of Scer\GAL4^Act.PU.

Co-expression of srl^EY05931 suppresses the wing defects caused by expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096.

(Mukherjee and Duttaroy, 2013)

Expression of Tor^TED.Scer\UAS suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19^GD9650 under the control of Scer\GAL4^ppk.PG at 16 hours after pupariation.

(Wong et al., 2013)

Co-expression of hppy^Scer\UAS.cMa and Tor^TED.Scer\UAS using Scer\GAL4^nub-AC-62 results in a strong synergistic phenotype of reduced wing size and reduced cell size and number.

Co-expression of hppy^GD12129 significantly rescues the reduced wing size caused by expression of Tor^TED.Scer\UAS using Scer\GAL4^nub-AC-62 or Scer\GAL4^MD-638.

(Resnik-Docampo and de Celis, 2011)

Expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Lsp2.PH cannot induce autolysosome formation in the fat body in a Acn¹/Acn²⁷ background.

(Haberman et al., 2010)

Expression of dominant-negative Tor^TED.Scer\UAS partially rescues the lethality cause by global expression (Scer\GAL4^αTub84B.PL) of SNF1A^{dsRNA.Scer\UAS}.

(Johnson et al., 2010)

Co-expression of Tor^TED.Scer\UAS and Gug^{75QN.Scer\UAS} in the eye under the control of Scer\GAL4^GMR.PU results in the formation of gigantic autophagolysosomes.

Expression of Gug^{75QN.Scer\UAS} under the control of Scer\GAL4^GMR.PU in Atg1^Δ3D mutant eyes fails to rescue cell degeneration.

Expression of Gug^Scer\UAS.cCa in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Tor^TED.Scer\UAS.

Expression of Gug^{66QC.Scer\UAS} in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Tor^TED.Scer\UAS.

Expression of Gug^{75QN.Scer\UAS} in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Tor^TED.Scer\UAS.

(Nisoli et al., 2010)

Expression of Tor^TED.Scer\UAS partially suppresses the glial neoplasia seen in third instar larvae when btl::Egfr^{Scer\UAS.T:λ\cI-DD} and Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} are co-expressed under the control of Scer\GAL4^repo.PU.

(Read et al., 2009)

Co-expression of Tor^TED.Scer\UAS partially suppresses the salivary gland overgrowth phenotype that is seen in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH and at 24 hours after puparium formation the salivary glands are predominantly degraded in the double mutant animals.

Co-expression of Tor^TED.Scer\UAS suppresses the salivary gland overgrowth phenotype that is seen in animals expressing Pi3K92E^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^fkh.PH and at 24 hours after puparium formation the salivary glands are predominantly degraded in the double mutant animals.

(Berry and Baehrecke, 2007)

The reduced wing phenotype caused by expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is partially suppressed by dm^Scer\UAS.cZa.

(Hennig and Neufeld, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

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Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Tor^DN

(Sênos Demarco et al., 2019)

Tor^TED.Scer\UAS

Tor^TED.UAS

mTor^TED.UAS

Name Synonyms

Secondary FlyBase IDs

References (53)

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