Mutant larvae are sensitive to methyl methanesulfonate (compared to control larvae). Mutant larvae are not sensitive to nitrogen mustard. Homozygous females display a severe defect in meiotic recombination, showing both very high levels of X chromosome nondisjunction (20.9%) and levels of meiotic recombination that are less than 3% of those seen in wild type. The defect in recombination is uniformly distributed across the entire chromosome arm.
The "mus215ZII-2059" stock has lost both the mutagen sensitivity and meiotic chromosome segregation phenotype that was seen in the first analysis of this line. This is possibly as a consequence of the accumulation of genetic modifiers or may be due to loss by recombination (assuming that it maps to a region of the second chromosome that is not well balanced by CyO). Efforts to recover the original mutant phenotype are in progress.